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Keywords: intervertebral disc degeneration
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Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-0170_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis high glucose intervertebral disc degeneration nucleus pulposus...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-1176_RET.
Published: 22 August 2024
... of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting the Editorial Office to suspected misconduct in three of these articles. apoptosis CDMP-2 intervertebral disc degeneration nucleus pulposus osmolarity © 2024 The Author(s). 2024...
Articles
Retraction: Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MPAK pathway
Open Access
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-1451_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . intervertebral disc degeneration nucleus pulposus p38 MAPK pH senescence...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-1708_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell apoptosis intervertebral disc degeneration nucleus pulposus...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-2312_RET.
Published: 22 August 2024
... bone morphogenetic protein-7 cell senescence intervertebral disc degeneration nucleus pulposus This article is one of twenty-five publications being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-0853_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . annulus fibrosus apoptosis high glucose intervertebral disc degeneration...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2017-1703_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis intervertebral disc degeneration nucleus pulposus resveratrol...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-2375_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . annulus fibrosus cell apoptosis intervertebral disc degeneration matrix...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2017-1454_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis glucose intervertebral disc degeneration nucleus pulposus...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-0126_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell senescence intervertebral disc degeneration nucleus pulposus...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-0544_RET.
Published: 22 August 2024
... autophagy intervertebral disc degeneration nucleus pulposus resveratrol This article is one of twenty-five publications being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2020-0262_RET.
Published: 22 August 2024
... intervertebral disc degeneration This article is one of twenty-five publications being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting the Editorial Office to suspected misconduct in three...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-0043_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis IL-1β intervertebral disc degeneration nucleus pulposus...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (10): BSR-20171523_RET.
Published: 06 October 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Intervertebral disc degeneration Nucleus pulposus cells p53 signaling...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR-20171523_EOC.
Published: 28 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Intervertebral disc degeneration Nucleus pulposus cells p53 signaling...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (7): BSR20200262.
Published: 30 June 2020
...Lianglong Pang; Keshi Yang; Zhi Zhang Diabetes mellitus (DM) is an important risk factor of intervertebral disc degeneration. However, how DM affects annulus fibrosus (AF) biology remains unclear. The present study was aimed to investigate the effects and mechanism of high glucose on AF cell...
Articles
Moracin attenuates LPS-induced inflammation in nucleus pulposus cells via Nrf2/HO-1 and NF-κB/TGF-β pathway
Open AccessRonghe Gu, Zonggui Huang, Huijiang Liu, Qiwen Qing, Zou Zhuan, Lijing Yang, Zhongyi Su, Weiguo Huang
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20191673.
Published: 04 December 2019
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . inflammation intervertebral disc degeneration LPS Moracin Nrf-2 Recently, growing evidences have shown...
Articles
Feng Cai, Xin Hong, Xiang Tang, Nai-Cheng Liu, Feng Wang, Lei Zhu, Xin-Hui Xie, Zhi-Yang Xie, Xiao-Tao Wu
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (11): BSR20192708.
Published: 13 November 2019
... activation of calpain and calcineurin, further resulting in increased mitochondrial permeability and mitochondrial-mediated apoptosis. Acid-sensing ion channel 1a Apoptosis Bone marrow mesenchymal stem cells Intervertebral disc degeneration Low back pain (LBP) is considered the most...
Articles
Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy
Open Access
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20190578.
Published: 07 August 2019
...Jiangwei Chen; Zunwen Lin; Kui Deng; Bin Shao; Dong Yang Background: Intervertebral disc degeneration is a common degenerative disease. The present study aimed to explore the role and mechanism of tension-induced endoplasmic reticulum stress in intervertebral disc degeneration. Methods...
Articles
High glucose promotes annulus fibrosus cell apoptosis through activating the JNK and p38 MAPK pathways
Open Access
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20190853.
Published: 08 July 2019
...Lizhen Shan; Di Yang; Danjie Zhu; Fabo Feng; Xiaolin Li Diabetes mellitus (DM) is an important risk factor of intervertebral disc degeneration. A high glucose niche-mediated disc cell apoptosis is an implicate causative factor for the spine degenerative diseases related with DM. However...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20190857.
Published: 28 June 2019
...Xiaoliang Bai; Wenyuan Ding; Sidong Yang; Xiaohui Guo Intervertebral disc degeneration (IDD) is a natural progression of the aging process associated with inflammation. Higenamine, a plant-based alkaloid, has been identified to possess various pharmacological properties, including anti-inflammatory...
Articles
Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro
Open Access
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20190126.
Published: 10 May 2019
...Xiaoming Li; Feixiang Lin; Yaohong Wu; Ning Liu; Jun Wang; Rongchun Chen; Zhijun Lu Intervertebral disc degeneration is a disease identified as an inflammation response-participated pathological process. As a classical cellular feature, disc cell senescence is reported to be closely related...
Articles
Ziming Liu, Zhiwen Zhang, Ali Zhang, Fan Zhang, Wennan Du, Yongqiang Zhang, Rongfeng Zhang, Jiagang Xu, Xiangkun Wu, Chengmin Zhang, Ning Li, Qi Tan, Wei Huang
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20190170.
Published: 02 April 2019
.... However, the cell apoptosis ratio was partly decreased when OP-1 was added into the high glucose culture medium ( Figure 1 ). apoptosis high glucose intervertebral disc degeneration nucleus pulposus osteogenic protein-1 Low back pain is a common musculoskeletal disease around the world...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (3): BSR20182462.
Published: 29 March 2019
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis intervertebral disc degeneration mechano growth factor mechanical overload nucleus pulposus Low back pain is the main cause of disability...
Articles
Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway
Open Access
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (3): BSR20190043.
Published: 26 March 2019
...Yanhai Jiang; Zhijie Xie; Jinying Yu; Lianqiang Fu Nucleus pulposus (NP) cell apoptosis is a classical cellular character during intervertebral disc degeneration (IDD). Previous studies have shown that inflammatory cytokine-induced NP cell apoptosis plays an important role in disc degeneration...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (3): BSR20182312.
Published: 19 March 2019
... increased cell proliferation of P6 human disc NP cells NP cell proliferation was measured by CCK-8 assay. Data are shown as mean ± S.D., n =3. *: Indicates a significant difference ( P <0.05). bone morphogenetic protein-7 cell senescence intervertebral disc degeneration nucleus pulposus...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (2): BSR20182375.
Published: 22 February 2019
... intervertebral disc degeneration matrix mechanical tension Figure 5 Expression of matrix metabolism-related enzymes Gene expression of TIMP-1, TIMP-3, MMP-3, and ADAMTS-4 in AF cells under different magnitudes (5, 10, and 20% elongations) of mechanical tension was analyzed by real-time PCR. Data...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181708.
Published: 14 December 2018
... intervertebral disc degeneration nucleus pulposus osteogenic protein-1 PI3K/Akt/mTOR Low back pain is a common and costly physical disease around the world, generating enormous socioeconomic burden and seriously affecting patient’s life quality [ 1 ]. Its global prevalence is estimated to reach 12...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20181176.
Published: 10 October 2018
... at 95°C, 8 s at 57°C, and 8 s at 72°C. The relative gene expression level was calculated according to the method of 2 −ΔΔ C T and normalized to the housekeeping gene β-actin . apoptosis CDMP-2 intervertebral disc degeneration nucleus pulposus osmolarity Low back pain is the most...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20171627.
Published: 06 July 2018
...Yimin Chen; Haitao Ma; Dawei Bi; Binsong Qiu Intervertebral disc degeneration (IDD) is a major pathological process implicated in low back pain and is a prerequisite to disk herniation. Interleukin-1 α (IL-1α) was thought to be involved in the pathogenesis of disc degeneration by increasing...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180544.
Published: 06 July 2018
... the expression of target genes. Gene expression was calculated with the method of 2 ―ΔΔ C t . autophagy intervertebral disc degeneration nucleus pulposus resveratrol Intervertebral disc (IVD) degeneration is the major cause of neck or back pain syndrome, which contributes to the drop in life...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (3): BSR20171523.
Published: 29 June 2018
...Liu-Zhong Jin; Ji-Shou Lu; Jian-Wen Gao Objective: Intervertebral disc degeneration (IDD), as a common cause of back pain, is related to the promotion of cellular senescence and reduction in proliferation. Based on recent studies, small ubiquitin-related modifier (SUMO) proteins have been...
Articles
Wenping Wang, Pei Li, Jiagang Xu, Xiangkun Wu, Zhiliang Guo, Lijing Fan, Ruipeng Song, Jianli Wang, Li Wei, Haijun Teng
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171454.
Published: 13 April 2018
.... Intervertebral disc degeneration (IDD) is a worldwide disease with multipathogenesis [ 1 ]. It can lead to stenosis, spine instability, and neurothlipsis [ 2 ]. Due to these complications, IDD is a main contributor to low back and leg pain [ 3 ]. The existing treatments are mainly aimed to symptom relief...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171703.
Published: 09 March 2018
... whether the resveratrol can attenuate mechanical compression-induced NP cell apoptosis and the subsequent alteration of ERK1/2 pathway activity in this regulatory process. apoptosis intervertebral disc degeneration nucleus pulposus resveratrol Intervertebral disc degeneration (IDD...
