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Keywords: leukaemia
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Biosci Rep (2019) 39 (1): BSR20181770.
Published: 15 January 2019
... ) 04 10 2018 02 12 2018 06 12 2018 17 12 2018 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . leukaemia...
Biosci Rep (2015) 35 (6): e00274.
Published: 08 December 2015
... leukaemia (AML), and constitutes a strong therapeutic target candidate. Like other Pim kinases, Pim2 is constitutively active and is believed to be essentially regulated through its accumulation. We show that in leukaemic cells, the three Pim2 isoforms have dramatically short half-lives although the longer...
Includes: Supplementary data
Biosci Rep (2013) 33 (6): e00081.
Published: 25 November 2013
...Vivian M. Rumjanek; Raphael S. Vidal; Raquel C. Maia The hallmark of CML (chronic myeloid leukaemia) is the BCR (breakpoint cluster region) –ABL fusion gene. CML evolves through three phases, based on both clinical and pathological features: a chronic phase, an accelerated phase and blast crisis...
Biosci Rep (2011) 31 (6): 477–487.
Published: 15 September 2011
... is more abundant in peripheral blood leucocytes. Here we report that α- D -mannosidase enzyme activity is very high in the promyelocytic leukaemia cell lines HL60 and NB4, as compared with other leukaemic cell lines or cells from different human sources. The MAN2B1 transcript level correlates with enzyme...
Biosci Rep (2011) 31 (5): 391–398.
Published: 05 August 2011
... To whom correspondence should be addressed (email gilma.trindade@gmail.com ). 13 10 2010 28 2 2011 2 3 2011 2 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 acetylsalicylic acid (ASA) antioxidant death cell gene expression leukaemia...
Includes: Supplementary data
Biosci Rep (2010) 30 (4): 217–222.
Published: 12 March 2010
...Jie Yao; Xiao-Bing Zhang; Xiao-li Zhang; Wei-Ling Fu Many studies have shown that epigenetic regulation of ERs (oestrogen receptors) plays a key role in the pathogenesis of leukaemia. In the present study, it was found that the methylated status of ERα-A might serve as an epigenetic biomarker...
Biosci Rep (2009) 29 (4): 211–216.
Published: 01 May 2009
...Jie Yao; Qing Huang; Xiao-Bing Zhang; Wei-Ling Fu Previous studies have suggested an important role of ERs (oestrogen receptors) in the pathogenesis of leukaemias. However, there is no information so far about the epigenetic characteristics of ERα isoforms and ERβ in leukaemias. In the present...
Biosci Rep (1995) 15 (6): 463–468.
Published: 01 December 1995
...Kingsley J. Micklem Using synthetic peptide or recombinant protein as immunising antigens we have produced monoclonal antibodies and polyclonal antisera directed against targets of particular interest in leukaemia diagnosis. In this way we have prepared reagents which recognise all T or all B...