...–lysosome and apoptosis associated proteins were identified. Further experiments characterize the expression of these proteins and their regulation in the process of apoptosis and autophagy. These findings may provide novel insights into the mechanisms of lysosome-associated pathways involved...

...Anthony O. Fedele; Christopher G. Proud Autophagy is dependent upon lysosomes, which fuse with the autophagosome to complete the autophagic process and whose acidic interior permits the activity of their intraluminal degradative enzymes. Chloroquine (CQ) and bafilomycin A1 (BafA) each cause...

... probes lysosome Programmed cell death (PCD) or apoptosis plays a vital role in animal development and tissue homoeostasis and is tightly regulated by a multitude of hydrolytic enzymes [ 1 , 2 ]. Subsequent to the activation of caspases, cells trigger a cascade of enzymes involved in digesting...

...Hua Zhao; Kalani Ruberu; Hongyun Li; Brett Garner Cbl (cobalamin) utilization as an enzyme cofactor is dependent on its efficient transit through lysosomes to the cytosol and mitochondria. We have previously proposed that pathophysiological perturbations in lysosomal function may inhibit...

...Bing Zhou; Yi-Bing Zhu; Lin Lin; Qian Cai; Zu-Hang Sheng The autophagy–lysosomal pathway is an intracellular degradation process essential for maintaining neuronal homoeostasis. Defects in this pathway have been directly linked to a growing number of neurodegenerative disorders. We recently...

...Alessandro Magini; Simona Mencarelli; Brunella Tancini; Virginia Ciccarone; Lorena Urbanelli; Andrej Hasilik; Carla Emiliani Hex (β-hexosaminidase) is a soluble glycohydrolase involved in glycoconjugate degradation in lysosomes, however its localization has also been described in the cytosol and PM...

...Tommaso Beccari; Lucia Bibi; Sofia Stinchi; John Laing Stirling; Aldo Orlacchio β-mannosidase is an exoglycosidase involved in the degradation of N-linked oligosacharides moieties of glycoproteins. Lack of β-mannosidase activity leads to the lysosomal disorder β-mannosidosis (MIM 248510). We have...