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Articles
Journal:
Bioscience Reports
Biosci Rep (2025) BSR20253205.
Published: 11 June 2025
Includes: Supplementary data
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 1: Effect of MPO and/or PAD4 inhibition on clinical outcomes and macroscopic colon damage in mice following eight days of DSS insult. ( a ) Percentage of the original weight from the start of the experiment to the day of sacrifice. ( b ) Percentage of original weight at the day of sacrific... More about this image found in Effect of MPO and/or PAD4 inhibition on clinical outcomes and macroscopic c...
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 2: Haematoxylin and eosin (H&E) staining of isolated mouse colons and histopathological evaluation. ( a ) Representative colon images from different groups were captured from Axio Lab.A1 light microscope with a Axiocam 105 Color camera at 10 x magnification. (i–v) The type and location... More about this image found in Haematoxylin and eosin (H&E) staining of isolated mouse colons and hist...
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 3: Alcian blue and Safranin O staining for goblet cells and mucin in mouse colons. ( a ) Representative colon images from different experimental groups were captured from Axio Lab.A1 light microscope with a Axiocam 105 Color camera at 20x magnification. (i–v) The area of goblet cell death ... More about this image found in Alcian blue and Safranin O staining for goblet cells and mucin in mouse col...
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 4: Toluidine Blue staining for mast cells (MC) in colon tissues. ( a ) Representative colon images from different experimental groups. Images were captured from Axio Lab.A1 light microscope with a Axiocam 105 Color camera at 40x and 63x magnifications as indicated on the figure. Scale bar ... More about this image found in Toluidine Blue staining for mast cells (MC) in colon tissues. (a) Represen...
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 5: The effect of pharmacological inhibition of MPO and/or PAD4 on the number of NETs in DSS-insulted colons. ( a ) Representative images of triple-plex immunofluorescence images of colons from different experimental groups were captured from Axio Scope.A1 fluorescence microscope with a Axi... More about this image found in The effect of pharmacological inhibition of MPO and/or PAD4 on the number o...
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 6: The effect of pharmacological inhibition of MPO and/or PAD4 on antioxidant signalling protein expressions and lipid peroxidation in colon tissue. Representative western blots bands with densiometric quantification graphs of ( a ) Nrf2, Nuclear factor erythroid 2-related factor 2. ( b ) ... More about this image found in The effect of pharmacological inhibition of MPO and/or PAD4 on antioxidant ...
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 7: The effect of MPO and/or PAD4 inhibition on antioxidant enzyme activities. ( a ) Total superoxide dismutase (SOD) activity. ( b ) Total catalase activity. Graphical values represent mean ± SD with n = 6–9 mice per group after standard curve interpolation. Normalcy of the collect data ... More about this image found in The effect of MPO and/or PAD4 inhibition on antioxidant enzyme activities. ...
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 8: The effect of MPO and/or PAD4 inhibition on inflammatory markers. ( a ) Interleukin (IL)-1β. ( b ) IL-4. Graphical values represent mean ± SD with n = 7–8 mice per group after standard curve interpolation. Normalcy of the collect data was analysed using Shapiro–Wilk test, group differ... More about this image found in The effect of MPO and/or PAD4 inhibition on inflammatory markers. (a) Inte...
Images
in The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
> Bioscience Reports
Published: 11 June 2025
Figure 9: Overview of the experimental timeline and group allocations. (i) Control group; (ii) DDS group, dextran sodium sulphate (DSS) at 2% w/v was administered to induce colitis; (iii) AZD group, myeloperoxidase (MPO) inhibitor AZD3241 at 30 mg/kg was provided to mice daily in peanut butter (P... More about this image found in Overview of the experimental timeline and group allocations. (i) Control g...
Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (06): BSR20241085.
Published: 05 June 2025
... Thr phosphorylation levels [ 10 , 13 ] under homeostasis and/or stress conditions in CassKB8. Nutritional status is a key regulator of protein synthesis and chaperone activity in various organisms. In eukaryotic cells, amino acid availability directly affects the activation of the mTOR pathway...
Includes: Supplementary data
Images
in Inhibition of protein or glutamine biosynthesis affect the light-induced dephosphorylation of the SBiP1 chaperone in Symbiodiniaceae
> Bioscience Reports
Published: 05 June 2025
Figure 1: The Thr phosphorylation response of SBiP1 in the presence of light and protein synthesis inhibitors. ( A ) Upper panel: representative western blots showing the level of Thr phosphorylation of SBiP1 (SBiP1-p) from dark-adapted CassKB8 cells in the presence of 0.1 mM cycloheximide (CHX) ... More about this image found in The Thr phosphorylation response of SBiP1 in the presence of light and prot...
Images
in Inhibition of protein or glutamine biosynthesis affect the light-induced dephosphorylation of the SBiP1 chaperone in Symbiodiniaceae
> Bioscience Reports
Published: 05 June 2025
Figure 2: Effect of cycloheximide treatment with or without a heat shock on CassKB8 cells during the dark-to-light transition. ( A ) Upper panels: representative western blots showing the level of Thr phosphorylation of SBiP1 (SBiP1-p) from dark-adapted CassKB8 cells incubated for 2 h before the ... More about this image found in Effect of cycloheximide treatment with or without a heat shock on CassKB8 c...
Images
in Inhibition of protein or glutamine biosynthesis affect the light-induced dephosphorylation of the SBiP1 chaperone in Symbiodiniaceae
> Bioscience Reports
Published: 05 June 2025
Figure 3: Cell viability in the presence of glufosinate. ( A ) CassKB8 cells after 12 h incubation under darkness with vehicle (control) or 1 mg/ml glufosinate (GLUF), stained with Evans blue [ 21 ] and showing marginal staining. In contrast, heat-killed cells (boiled) show heavy staining. ( B ) ... More about this image found in Cell viability in the presence of glufosinate. (A) CassKB8 cells after 12 ...
Images
in Inhibition of protein or glutamine biosynthesis affect the light-induced dephosphorylation of the SBiP1 chaperone in Symbiodiniaceae
> Bioscience Reports
Published: 05 June 2025
Figure 4: Effect of glufosinate on the Thr phosphorylation behavior of SBiP1 during the dark-to-light transition. ( A ) Upper panels: representative western blots showing the level of SBiP1 Thr phosphorylation (SBiP1-p) from dark-adapted CassKB8 cells exposed to 1 mg/ml glufosinate (GLUF), compar... More about this image found in Effect of glufosinate on the Thr phosphorylation behavior of SBiP1 during t...
Images
in Inhibition of protein or glutamine biosynthesis affect the light-induced dephosphorylation of the SBiP1 chaperone in Symbiodiniaceae
> Bioscience Reports
Published: 05 June 2025
Figure 5: Proposed hypothetical model of factors that influence the phosphorylation/dephosphorylation of the SBiP1 chaperone by light. During the dark photoperiod phase, metabolic processes are shut down and SBiP1 is fully phosphorylated (hypothetically inactive; light green croissant) by an unkn... More about this image found in Proposed hypothetical model of factors that influence the phosphorylation/d...
Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (05): 343–360.
Published: 28 May 2025
... to activate NF–κB and mTOR signaling pathways, thereby regulating cell growth and proliferation [ 44 ]. Cxcr4 plays a role in leukocyte chemotaxis during inflammatory conditions in various autoimmune diseases, and elevated levels of Cxcr4 have been observed in various types of human cancers [ 45 ]. In our...
Includes: Supplementary data
Images
in Single-cell RNAseq of Angiotensin II-induced abdominal aortic tissue identifies aneurysm-associated cell clusters in C57BL/6J mice
> Bioscience Reports
Published: 28 May 2025
Figure 1: Age and dose effects in Ang II-induced AAA in mice. ( A ) Representative ultrasound images from C57BL/6 J mice treated with either PBS or Ang II (1.44 mg/kg/day or 2.16 mg/kg/day) at the age of 14 weeks. Scale bars: 2 mm. ( B ) Representative images of the mouse aorta at 14 weeks of age... More about this image found in Age and dose effects in Ang II-induced AAA in mice. ( A ) Representative u...
Images
in Single-cell RNAseq of Angiotensin II-induced abdominal aortic tissue identifies aneurysm-associated cell clusters in C57BL/6J mice
> Bioscience Reports
Published: 28 May 2025
Figure 2: Cell types classified through single-cell RNA sequencing (scRNAseq) of mouse aortas. ( A ) After quality control, 8,716, 8,443, and 12,276 cells from the normal control (NC), without AAA formation (no-AAA), and with AAA formation (AAA) groups were selected for clustering analysis, respe... More about this image found in Cell types classified through single-cell RNA sequencing (scRNAseq) of mous...
Images
in Single-cell RNAseq of Angiotensin II-induced abdominal aortic tissue identifies aneurysm-associated cell clusters in C57BL/6J mice
> Bioscience Reports
Published: 28 May 2025
Figure 3: Comparison of endothelial cell subpopulations in the abdominal aorta among the NC, no-AAA, and AAA groups. ( A ) Stacked column chart shows the proportion of endothelial cell subtypes in the NC, no-AAA, and AAA groups. The proportion of endothelial cell subtypes among the three groups w... More about this image found in Comparison of endothelial cell subpopulations in the abdominal aorta among ...
Images
in Single-cell RNAseq of Angiotensin II-induced abdominal aortic tissue identifies aneurysm-associated cell clusters in C57BL/6J mice
> Bioscience Reports
Published: 28 May 2025
Figure 4: Comparison of macrophages in the abdominal aorta among the NC, no-AAA, and AAA group. ( A ) The expression of selected marker genes Ccl4, Cxcl10, Spp1 for the macrophage cluster from NC, no-AAA, and AAA groups is visualized through feature plots. ( B ) Representative immunofluorescenc... More about this image found in Comparison of macrophages in the abdominal aorta among the NC, no-AAA, and ...
Images
in Single-cell RNAseq of Angiotensin II-induced abdominal aortic tissue identifies aneurysm-associated cell clusters in C57BL/6J mice
> Bioscience Reports
Published: 28 May 2025
Figure 5: Comparison of fibroblast subpopulations in the abdominal aorta among the NC, no-AAA, and AAA group. ( A ) Stacked column chart depicting the proportion of fibroblast subtypes in NC, no-AAA, and AAA groups. The proportions of fibroblast subtypes in the three groups listed are statistical... More about this image found in Comparison of fibroblast subpopulations in the abdominal aorta among the NC...
Images
in Single-cell RNAseq of Angiotensin II-induced abdominal aortic tissue identifies aneurysm-associated cell clusters in C57BL/6J mice
> Bioscience Reports
Published: 28 May 2025
Figure 6: Visualization and analysis of cell–cell communication through circle plots. The number and strength of interactions between pairs of 12 cell clusters are shown. The sizes of the circles are proportional to the number of cells in each cluster; the larger the circle, the greater the numbe... More about this image found in Visualization and analysis of cell–cell communication through circle plots....
Images
in Single-cell RNAseq of Angiotensin II-induced abdominal aortic tissue identifies aneurysm-associated cell clusters in C57BL/6J mice
> Bioscience Reports
Published: 28 May 2025
Figure 7: Dot plot illustrating selected ligand–receptor interactions in various cell subsets. ( A ) Ligand and receptor pairs are displayed on the x-axis, while the cell subsets are presented on the y-axis. The color of the dot indicates the signaling probability scores of the receptor–ligand pa... More about this image found in Dot plot illustrating selected ligand–receptor interactions in various cell...
Articles
Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications
Open Access
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (05): 303–323.
Published: 13 May 2025
Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (05): 325–342.
Published: 13 May 2025
Includes: Supplementary data
Images
in Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications
> Bioscience Reports
Published: 13 May 2025
Figure 1: The effects of polydatin on glucose and lipid metabolism. Abbreviations: ACC, acetyl-CoA carboxylase; AMPK, AMP-activated protein kinase; FA, fatty acid; G6Pase, glucose 6-phosphatase; GCK, glucokinase; GSK-3β, glycogen synthase kinase-3 beta; IRS-1/2, insulin receptor substrate-1 or 2;... More about this image found in The effects of polydatin on glucose and lipid metabolism. Abbreviations: A...
Images
in Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications
> Bioscience Reports
Published: 13 May 2025
Figure 2: Nephroprotective actions of polydatin. Abbreviations: AP-1, activator protein-1; ARE, antioxidant response element; Cx32, connexin 32; HO-1, heme oxygenase-1; ICAM-1, intercellular adhesion molecule-1; Keap1, Kelch-like ECH associated-protein 1; NF-κB, nuclear factor kappa B; Nrf2, nucl... More about this image found in Nephroprotective actions of polydatin. Abbreviations: AP-1, activator prot...
Images
in Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications
> Bioscience Reports
Published: 13 May 2025
Figure 3: Protective effects of polydatin against a wide range of diabetic complications. Created in BioRender. Tang, K. (2025) https://BioRender.com/f61o708 . More about this image found in Protective effects of polydatin against a wide range of diabetic complicati...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 1: Human perirenal adipose-derived stromal cell (h-prASC) secretomes enhance human umbilical vein endothelial cell (HUVEC) angiogenic capacity. ( A-F ) Representative images of tube formation with HUVEC exposed to the various h-prASC secretomes for 20 hours. Scale bar, 100 µm. Exposure to ... More about this image found in Human perirenal adipose-derived stromal cell (h-prASC) secretomes enhance h...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 2: Rat perirenal adipose-derived stromal cell (r-prASC) secretomes enhance rat aortic endothelial cell (RAEC) angiogenic capacity. ( A-F ) Representative images of tube formation with RAEC exposed to the various r-prASC secretomes for 20 hours. Scale bar, 100 µm. Exposure to ( A ) standard... More about this image found in Rat perirenal adipose-derived stromal cell (r-prASC) secretomes enhance rat...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 3: Human perirenal adipose-derived stromal cell (h-prASC) secretomes stimulate collagen secretion by human fibroblasts. ( A-F ) Representative images of Picrosirius red staining in human fibroblasts exposed to various h-prASC secretomes for 72 hours. Scale bar, 50 µm. Exposure to ( A ) sta... More about this image found in Human perirenal adipose-derived stromal cell (h-prASC) secretomes stimulate...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 4: Rat perirenal adipose-derived stromal cell (r-prASC) secretomes stimulate collagen secretion by rat fibroblasts. ( A ) ( A−F ) Representative images of Picrosirius-red staining in rat fibroblasts exposed to various r-prASC secretomes for 72 hours. Scale bar, 50 µm. Exposure to ( A ) sta... More about this image found in Rat perirenal adipose-derived stromal cell (r-prASC) secretomes stimulate c...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 5: Human perirenal adipose-derived stromal cell (h-prASC) secretomes modulate antibody-mediated immune responses. The effect of various h-prASC secretomes on humoral alloimmunity was evaluated using a mixed lymphocyte reaction (MLR) followed by an antibody-mediated complement-dependent cyt... More about this image found in Human perirenal adipose-derived stromal cell (h-prASC) secretomes modulate ...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 6: Rat perirenal adipose-derived stromal cell (r-prASC) secretomes modulate antibody-mediated immune responses. The effect of various r-prASC secretomes on humoral alloimmunity was evaluated using a MLR followed by an antibody-mediated complement-dependent cytotoxicity (CDC) assay. The out... More about this image found in Rat perirenal adipose-derived stromal cell (r-prASC) secretomes modulate an...
Articles
Articles
Toward safer and sustainable food preservation: a comprehensive review of bacteriocins in the food industry
Open Access
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (04): 277–302.
Published: 17 April 2025
Images
in Toward safer and sustainable food preservation: a comprehensive review of bacteriocins in the food industry
> Bioscience Reports
Published: 17 April 2025
Figure 1: Schematic representation of lantibiotic biosynthesis, maturation, antimicrobial action, and self-immunity mechanisms in the producer cell. The biosynthetic process begins with gene cluster transcription and precursor peptide synthesis, which includes an N-terminal leader peptide prevent... More about this image found in Schematic representation of lantibiotic biosynthesis, maturation, antimicro...
Images
in Toward safer and sustainable food preservation: a comprehensive review of bacteriocins in the food industry
> Bioscience Reports
Published: 17 April 2025
Figure 2: Guide for the evaluation and approval of new bacteriocins for food applications. A diagram is presented illustrating the essential steps for evaluating and approving new bacteriocins intended for use in food applications. More about this image found in Guide for the evaluation and approval of new bacteriocins for food applicat...
Articles
Images
Published: 11 April 2025
Figure 1: Phylogenetic analysis of UDP-glucose pyrophosphorylases (UGPases) from different organisms. Yellow background, UGPases from plants. Blue background, UGPases from fungi. Red background, UGPases from animals. Green background, UGPases from bacteria E. coli . Multiple sequence alignment w... More about this image found in Phylogenetic analysis of UDP-glucose pyrophosphorylases (UGPases) from diff...
Images
Published: 11 April 2025
Figure 2: The purified UGPases and specific activity of UGPase from different organisms. ( A ) SDS-PAGE (12% gel) analysis of the purified UGPases from different organisms. M, protein marker; marker ladders are in kDa. ( B ) The specific activity of UGPases. The biological triplicates were perfor... More about this image found in The purified UGPases and specific activity of UGPase from different organis...
Images
Published: 11 April 2025
Figure 3: Temperature and pH optima of various UDP-glucose pyrophosphorylases (UGPases). ( A ) Temperature optima. The highest activity for each UGPase at a specific temperature is defined as 100%. ( B ) pH optima. The highest activity for each UGPase at a specific pH is defined as 100%. The biol... More about this image found in Temperature and pH optima of various UDP-glucose pyrophosphorylases (UGPase...
Images
Published: 11 April 2025
Figure 4: Thermal stability of recombinant UGPases. ( A ) EcUGP; ( B ) ScUGP; ( C ) AnUGP; ( D ) HvUGP; ( E ) AtUGP; ( F ) StUGP; ( G ) MeUGP; ( H ) IbUGP; ( I ) ZmUGP; ( J ) DmUGP; ( K ) HsUGP. The recombinant UGPases were incubated in the MOPS-KOH buffer (50 mM, pH 7.0) at 37°C, 50°C, 60°C, and... More about this image found in Thermal stability of recombinant UGPases. ( A ) EcUGP; ( B ) ScUGP; ( C ) ...
Images
Published: 11 April 2025
Figure 5: The substrate preferences of recombinant UDP-glucose pyrophosphorylases (UGPases). ( A ) The preference of sugar phosphates Glc1P, Gla1P, GlcA1P, and GlcNAc1P. The highest UGPase activity was measured when using Glc1P as a substrate, which is defined as 100%. ( B ) The preference of nuc... More about this image found in The substrate preferences of recombinant UDP-glucose pyrophosphorylases (UG...
Images
Published: 11 April 2025
Figure 6: The kinetic curves of recombinant UGPases. The kinetic curves of recombinant UGPases toward substrate Glc1P. ( A ) EcUGP; ( B ) ScUGP; ( C ) AnUGP; ( D ) HvUGP; ( E ) AtUGP; ( F ) StUGP; ( G ) MeUGP; ( H ) IbUGP; ( I ) ZmUGP; ( J ) DmUGP; ( K ) HsUGP. An, A. niger ; At, A. thaliana ; ... More about this image found in The kinetic curves of recombinant UGPases. The kinetic curves of recombina...
Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (04): 247–262.
Published: 09 April 2025
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (04): 233–245.
Published: 09 April 2025
Includes: Supplementary data
Images
Published: 09 April 2025
Figure 1: Plot of the correlation between phenotypic allostatic load and the epigenetic signature in the SKIPOGH cohort. ( A ). The correlation between AL-GP (the phenotype-based score) and the methAL signature. ( B ). The correlation between AL-GP and the HM-450K compatible methALT signature, st... More about this image found in Plot of the correlation between phenotypic allostatic load and the epigenet...
Images
Published: 09 April 2025
Figure 2: Plot of odds ratios and 95% confidence intervals for probability of history of cardiovascular disease corresponding to different measures of allostatic load. Odds ratios and 95% confidence intervals for the association between measures of AL and a history of cardiovascular disease. Pres... More about this image found in Plot of odds ratios and 95% confidence intervals for probability of history...
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