... displayed pathological changes, CD4 + /CD8 + T cells imbalance, and increased neutrophils, monocytes, and macrophages infiltration. A significant expansion of MDSCs could be seen in CS-affected respiratory and gastrointestinal tract. Importantly, higher expression of MDSCs-related effector molecules...

...Waruni C. Dissanayake; Jin Kyo Oh; Brie Sorrenson; Peter R. Shepherd High glucose levels are associated with changes in macrophage polarisation and evidence indicates that the sustained or even short-term high glucose levels modulate inflammatory responses in macrophages. However, the mechanism...

... in B-cell development their role in immunity has not been extensively studied. In innate immune cells such as macrophages, TLRs drive the production of both pro- and anti-inflammatory cytokines. IL-10 is an important anti-inflammatory cytokine produced by macrophages and it establishes an autocrine...

... cholangiocarcinoma macrophages miRNA Wnt Wnt/β-catenin signaling comprises Wnt ligands, which are 350–400 amino acids long lipid-modified glycoproteins and CTNNB1 gene-encoded multifunctional β-catenin proteins [ 4 ]. In canonical Wnt/β-catenin signaling, the activation of Wnt leads to translocation...

... and TNF-α in Raw264.7 murine macrophages stimulated by LPS. Real-time PCR assay demonstrated the SOG dose-dependently inhibited transcription of these cytokines as well. In addition, it was also found that NF-κB activation and MAPKs phosphorylation including p38, JNK and ERK1/2 induced by LPS were...

... formed a hairpin and had more than one target involved in immunoregulation. Culture of macrophages, RT-PCR and ELISA assays showed that cells internalized miR-10-5p and let-7-5p into the cytoplasm and the miRs strongly decreased interleukin 16 ( Il6 ) expression, tumor necrosis factor (TNF) and IL-12...

... therapeutic approach aims to target Glioma-associated microglia/macrophages (GAMs). We investigated the molecular profile of GAMs correlated with patient prognosis by exploiting M1/M2-like polarization markers in a cohort of 20 GBM patients. Using quantitative PCR (qPCR), the markers CXCL10 (M1) and CCL13 (M2...

... (CF) patients. However, little is known about the role of CFTR in vascular inflammation and atherogenesis. Our results showed that CFTR was dominantly expressed in macrophages of atherosclerotic plaque and reduced in aorta and aortic sinus from atherosclerotic apolipoprotein E-deficient (apoE...

...Dan Yan; Yujuan He; Jun Dai; Lili Yang; Xiaoyan Wang; Qiurong Ruan Macrophages are largely involved in the whole process of atherosclerosis from an initiation lesion to an advanced lesion. Endothelial disruption is the initial step and macrophage-derived foam cells are the hallmark...

... factor-α (TNF-α) synthesis and TNF-α has been shown to regulate NAD + homoeostasis providing a link between a pro-inflammatory response and redox status. In the present study, we have used THP-1 differentiation into pro- (M1-like) and anti- (M2-like) inflammatory macrophage subset models to investigate...

...Debjani Ghosh; Prasanta Chakraborty In this study we show that protein tyrosine kinases (PTKs) and also protein tyrosine phosphatases are involved in the uptake of virulent and avirulent Leishmania donovani promastigotes by macrophage cells. Protein tyrosine kinase inhibitors such as genistein...

...% of the interleukin 3 added to the medium being predominantly present in the cytosolic fraction (73%). Uptake fell to about 7.4% when using the same conditions but omitting hypotonic shock. The interaction of band 3 crosslinked interleukin 3 loaded erythrocytes with macrophages was also studied. A high level...

...Dalia Dasgupta; Prasanta Chakraborty; Mukul K. Basu The fMLP receptor of peritoneal macrophages stimulated by fMLP graftedliposomes as ligand, was analysed and compared with respective controlsfor its ability to promote killing of intracellular Leishmaniaparasites. fMLP grafted liposomes show...

... 1989 alpha 1 -antitrypsin protein structure function variants genetically engineered mutants gene structure macrophages alternative transcripts hepatocyte cis and trans regulators serpin gene family Bioscience Reports, Vol. 9, No. 2, 1989 REVIEW Alpha,-Antitrypsin: Structure, Function...