... innate immune cells. Granzymes B and C are encoded in the mouse chymase locus that also encodes a number of mast cell-specific proteases. In line with this, mast cells can express granzyme B, although how this is regulated and their ability to express other granzymes is less well studied. We therefore...

...Nathan M. Ryan; Steve Oghumu Mast cells are long-lived, innate immune cells of the myeloid lineage which are found in peripheral tissues located throughout the body, and positioned at the interface between the host and the environment. Mast cells are found in high concentrations during helminth...

...Yoko Usami; Yukihiro Kobayashi; Takahiro Kameda; Akari Miyazaki; Kazuyuki Matsuda; Mitsutoshi Sugano; Kenji Kawasaki; Yuriko Kurihara; Takeshi Kasama; Minoru Tozuka MCs (mast cells) adversely affect atherosclerosis by promoting the progression of lesions and plaque destabilization. MC chymase...

...Reinhold Penner; Michael Pusch; Erwin Neher Transient increases of intracellular calcium and exocytotic activity of rat peritoneal mast cells following stimulation with compound 48/80 were monitored using the Ca-indicator dye fura-2 and the capacitance measurement technique. It is known that mast...