...Wei Han; Biao Huang; Xiao-Yu Zhao; Guo-Liang Shen Skin cutaneous melanoma (SKCM) is one of the most deadly malignancies. Although immunotherapies showed the potential to improve the prognosis for metastatic melanoma patients, only a small group of patients can benefit from it. Therefore...

...Wei Li; Yubo Zhou Intratumoral hypoxia is a well-known feature of solid cancers and constitutes a major contributor to cancer metastasis and poor outcomes including melanoma. Leucine-rich repeats and Ig-like domains 1 (LRIG1) participate in the aggressive progression of several tumors, where its...

...Hao Liu; Liping Yang; Min Qi; Jianglin Zhang Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. Nuclear factor of activated T cell (NFAT1) has been shown to promote melanoma growth and metastasis in vivo . We herein aim to investigate whether NFAT1...

...Paola M. Dantonio; Marianne O. Klein; Maria Renata V.B. Freire; Camila N. Araujo; Ana Carolina Chiacetti; Ricardo G. Correa Although most melanoma cases may be treated by surgical intervention upon early diagnosis, a significant portion of patients can still be refractory, presenting low survival...

...Xiangjun Chen; Sha Liu; Xiaochun Zhao; Xiao Ma; Guozhen Gao; Li Yu; Dexiong Yan; Hao Dong; Weijing Sun Melanoma is the most malignant skin cancer, which account for most of skin-cancer-related deaths. Long noncoding RNA (lncRNA) is a class of noncoding RNAs with crucial roles in many cancers...

... significance and roles of lncRNA-HEIH in melanoma are still unknown. In the present study, we found that lncRNA-HEIH is highly expressed in melanoma tissues and cell lines, associated with advanced clinical stages, and predicts poor outcomes in melanoma patients. Functional assays showed that ectopic...

...Rolando Pérez-Lorenzo; Bin Zheng Malignant melanoma is the most aggressive form of skin cancer and its incidence has increased dramatically in the last two decades. Even with a high rate of success in the treatment of early stages of this malignancy, currently there are no effective strategies...

...Andrzej Slominski; Pawel Jastreboff; John Pawelek L-tyrosine, a precurosr to melanin, has recently been shown to be a regulator of the melanogenic pathway in some cultured melanoma cell lines. In this paper we demonstrated that L-tyrosine, besides increasing binding capacity for MSH, decreased...