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Keywords: metastasis
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Articles
Biosci Rep (2021) BSR20211577.
Published: 07 December 2021
.... Ribosomes ribosomal proteins Cancer cell survival apoptosis metastasis Deregulation of Ribosomal Proteins in Human Cancers Wendy El Khoury1 and Zeina Nasr1* 1 Department of Biology, Faculty of Arts and Sciences, University of Balamand, Lebanon *Corresponding authors: zeina.nasr@balamand.edu.lb...
Articles
Biosci Rep (2021) 41 (10): BSR20211137.
Published: 19 October 2021
... 1 to grade 4), ( B ) clinical stages (from stage 1 to stage 4), ( C ) patient’s race, ( D ) nodal metastasis statuses (from N0 to N3), ( E ) HPV status, ( F ) TP53 mutation status, ( G ) patient’s age and ( H ) gender. ( I ) The expression of CCT3 in metastatic and primary HNSCC tissues was detected...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (10): BSR20211056.
Published: 06 October 2021
... after treatment with digoxin, with an increase in autophagosome foci. In addition, digoxin inhibited the phosphorylation of Akt, mTOR and p70S6K, signaling molecules of the PI3K/Akt pathway that are known to be involved in tumor cell survival, proliferation, metastasis and autophagy. Our findings...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (8): BSR-2018-1175_RET.
Published: 06 August 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell growth Gastric cancer Metastasis MicroRNA-27a Neoadjuvant...
Articles
Biosci Rep (2021) 41 (7): BSR20193514.
Published: 26 July 2021
...Wei Mai; Lingyu Kong; Hongwei Yu; Junjie Bao; Chunyu Song; Guofan Qu Aim: Typical features of human osteosarcoma are highly invasive and migratory capacities. Our study aimed to investigate the roles of glycogen synthase kinase 3β (GSK3β) in human osteosarcoma metastasis. Methods: GSK3β expressions...
Articles
Biosci Rep (2021) 41 (2): BSR20203121.
Published: 03 February 2021
...Haomeng Zhang; Jiao Wang; Yulong Yin; Qingjie Meng; Yonggang Lyu Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC...
Articles
Biosci Rep (2021) 41 (1): BSR20201178.
Published: 22 January 2021
... into five groups: Vehicle, cyclophosphamide (CTX, 20 mg/kg), TSRP (25 mg/kg), TSRP (50 mg/kg) and TSRP (100 mg/kg) groups for 14 days’ treatment. In addition, the melanoma metastasis in lung in vivo of TSRP was detected in A375 tail vein injection mice, and the histopathalogical analysis of the lung...
Articles
Biosci Rep (2021) 41 (1): BSR20201539.
Published: 04 January 2021
... was assessed by RT-PCR and Western blot. Besides, Kaplan–Meier survival analysis was recruited to explore the association between TNS1 and NSCLC. Cell growth was analyzed by MTT and flow cytometry assay, while cell metastasis was determined by wound healing and transwell assays. The targeting relationship...
Articles
Biosci Rep (2020) 40 (11): BSR20201854.
Published: 02 November 2020
... suggested that PRR11 was up-regulated in breast cancer. Silencing PRR11 mediated by US showed a higher efficiency than by Lipofectamine 3000. SiPRR11 transfected by Lipofectamine 3000 suppressed cells growth and metastasis, while promoted cell apoptosis. Moreover, E-cadherin (E-cad) and Bax expressions were...
Articles
Biosci Rep (2020) 40 (10): BSR20200367.
Published: 30 October 2020
...Yue Zhong; Qiang Lu; Wei Qiu; Yan Luo Background: Metastasis is a major obstacle in treatment of cervical cancer, and long non-coding RNA (lncRNA) mediated regulatory effect on associated genes expression is found to be involved in metastasis. However, its mechanisms have not been fully elucidated...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (8): BSR20200437.
Published: 25 August 2020
... detected in HCT116 and HT29 cell lines. In HCT116 and HT29 cells, CD133 + CD44 + cells not only shared the extensive tumorigenic potential of LT-TICs but also functionally reproduced the behaviors of LT-TICs that drive tumor metastasis (TM) formation, suggesting that CD133 + CD44 + cells are a typical...
Articles
Biosci Rep (2020) 40 (8): BSR-20190159_COR.
Published: 07 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Isorhamnetin Lung cancer Metastasis Epithelial-mesenchymal transition (EMT...
Articles
Biosci Rep (2020) 40 (7): BSR-20181175_EOC.
Published: 29 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell growth Efficacy Gastric cancer Metastasis MicroRNA-27a Neoadjuvant...
Articles
Biosci Rep (2020) 40 (7): BSR20201001.
Published: 15 July 2020
... of cancer deaths worldwide. Its high-frequency metastasis and relapse rate lead to the poor survival of HCC patients. However, the mechanism of HCC metastasis is still unclear. Alternative splicing events (ASEs) have a great effect in cancer development, progression and metastasis. We downloaded RNA...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR-20190159_EOC.
Published: 30 June 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Isorhamnetin Lung cancer Metastasis Epithelial-mesenchymal transition (EMT...
Articles
Biosci Rep (2020) 40 (6): BSR20191062.
Published: 17 June 2020
...Jun Liu; Feng Xu; Jie Li; Hongchuan Jiang Objectives: The high mortality of breast cancer (BC) is associated with the strong metastatic properties of primary breast tumor cells. The present study was conducted in order to clarify the effect of Cosmc on the growth and metastasis of BC cell lines...
Articles
Biosci Rep (2020) 40 (4): BSR20200390.
Published: 28 April 2020
...Yi Yao; Nan Li Background: Metastasis and chemoresistance indicate a poor prognosis in colorectal cancer (CRC) patients. However, the mechanisms that lead to the development of chemoresistance and metastasis in CRC remain unclear. Materials and methods: We combined clinical and experimental studies...
Articles
Biosci Rep (2020) 40 (3): BSR20200049.
Published: 27 March 2020
... cortical carcinoma (ACC). Methods: A ceRNA network was established to identify the ceRNAs involved in metastasis of ACC based on 92 samples from TCGA, including 18 cases of metastasis and 74 cases of non-metastatic primary tumors. And the algorithm “cell type identification by estimating relative subsets...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (3): BSR20200265.
Published: 20 March 2020
..., ErbB, RHOA, Notch, BMP, Hippo, AMPK, NF-κB, MAPK and JNK. Subsequently, we discussed the biological function of these pathways in pathophysiological aspects of CRC, such as proliferation, apoptosis and metastasis. Finally, we summarized important interactions among these pathways in CRC. We believe...
Articles
Biosci Rep (2020) 40 (3): BSR20192826.
Published: 18 March 2020
... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Isorhamnetin Metastasis PI3K/Akt/mTOR Prostate cancer Prostate cancer represents as one of the most commonly diagnosed cancer in the United States...
Articles
Biosci Rep (2020) 40 (3): BSR20194342.
Published: 09 March 2020
...Shuai Wu; Jian Xie; Hao Shi; Zi-wei Wang Objective: Metastasis and chemoresistance indicate treatment fail and progresses in gastric cancer (GC) patients. However, the molecular mechanisms of chemoresistance and metastasis remain unclear in GC. Thus, identifying the biological indicators...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (2): BSR20194335.
Published: 28 February 2020
...Dan-dan Hu; Hai-ling Chen; Li-ming Lou; Hong Zhang; Guo-liang Yang The processes that lead to lung adenocarcinoma (LUAD) metastasis are poorly characterized. Spindle and kinetochore associated complex subunit 3 (SKA3) plays a key role in cervical cancer development, but its contribution to LUAD...
Articles
Biosci Rep (2019) 39 (9): BSR20190159.
Published: 20 September 2019
...Wei Luo; Qingbin Liu; Nan Jiang; Mingquan Li; Li Shi In the present study, we investigated the potential effects of Isorhamnetin on the growth and metastasis of A549 human lung cancer cells, as well as the underlying mechanism. Treatment with Isorhamnetin exhibited a dose- and time-dependent...
Articles
Biosci Rep (2019) 39 (9): BSR20190489.
Published: 03 September 2019
... and cells. High LUCAT1 expression was strongly associated with advanced stages and poor prognosis of TNBC. LUCAT1 contributed to TNBC development through accelerating cell proliferation, cell cycle progression and metastasis as well as attenuating cell apoptosis. Moreover, miR-5702 was proved to directly...
Articles
Biosci Rep (2019) 39 (8): BSR20191611.
Published: 23 August 2019
... 2019 05 08 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . AKT3 breast cancer metastasis miRNA NF-κB...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (8): BSR20190906.
Published: 02 August 2019
... RNA Metastasis Prognosis Proliferation Wnt/β-catenin signaling Human ovarian cancer, one of the most common gynecologic neoplasms, is responsible for the highest mortality among women, and represents a major concern for women’s health worldwide [ 1 , 2 ]. And nearly nine in ten female...
Articles
Biosci Rep (2019) 39 (7): BSR20190634.
Published: 12 July 2019
... Attribution License 4.0 (CC BY) . AJUBA CCND1 HEG1 Lung cancer Metastasis microRNA-193b Despite the remarkable development of lung cancer therapies, lung cancer has been classified as a major cause of death [ 1 ]. Its unfavorable clinical outcomes originate from its high invasive...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (7): BSR20182082.
Published: 05 July 2019
...Xue Yang; Gaopei Meng In order to optimize patient-tailored chemotherapy, a non-small-cell lung cancer (NSCLC)-liver metastasis patient-derived tumor xenograft (PDTX) model is developed. Computed tomography (CT)-guided NSCLC percutaneous biopsy was subcutaneously inoculated into the flank of non...
Articles
Biosci Rep (2019) 39 (6): BSR20190077.
Published: 10 June 2019
... carcinoma metastasis miR-940 MRVI1 proliferation Endometrial cancer (EC) is one of the most common reproductive system malignancies for females in the world, and the incidence of this disease is rapidly increasing in recent years [ 1 ]. Of note, increasing annual incidence rate of 3.7% has been...
Articles
Biosci Rep (2019) 39 (6): BSR20181339.
Published: 04 June 2019
... BY) . cervical Cancer EMT Long non-coding RNA metastasis miR-101-3p SPRY4-IT1 Cervical cancer (CC) is the fourth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths among females worldwide [ 1 ]. With the improvement of diagnostic techniques and therapeutic...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (5): BSR20181175.
Published: 21 May 2019
...Chunlei Xu; Hong Cheng; Na Li; Ning Zhou; Xushan Tang Objective: The aim of the present study is to investigate the relationship between microRNA-27a (miR-27a) and the efficacy of neoadjuvant chemotherapy in gastric cancer (GC) and its mechanism in the growth and metastasis of GC cells. Methods...
Articles
Biosci Rep (2019) 39 (5): BSR20181573.
Published: 21 May 2019
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . intrahepatic cholangiocarcinoma lncRNA-NEF metastasis Runt-related transcription factor 1 (RUNX1) survival As a rare type of cholangiocarcinoma forms in the bile ducts, intrahepatic cholangiocarcinoma (IHCC...
Articles
Biosci Rep (2019) 39 (4): BSR20182384.
Published: 17 April 2019
... 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug resistance growth metastasis sorafenib Hepatocellular carcinoma (HCC...
Articles
Biosci Rep (2019) 39 (4): BSR20190016.
Published: 16 April 2019
... inhibiting the protein expressions of several transcriptional or surface markers of cancer stem cells. These findings first suggest that CHTOP, as a highly expressed protein in ovarian cancer, is closely associated with the malignant phenotypes of epithelial ovarian cancer cells, including metastasis...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (4): BSR20182186.
Published: 02 April 2019
... of the present study was to investigate SNHG20 clinical significance and its underlying mechanism in proliferation and metastasis in EOC. The expression level of SNHG20 was identified via in situ hybridization (ISH) and quantitative RT-PCR (qRT-PCR). The proliferative and metastatic capacities by silencing...
Articles
Biosci Rep (2019) 39 (3): BSR20181937.
Published: 15 March 2019
...Xian-Ping Cui; Chuan-Xi Wang; Zhi-Yi Wang; Jian Li; Ya-Wen Tan; Song-Tao Gu; Cheng-Kun Qin LncRNA TP73 antisense RNA 1T (TP73-AS1) plays an important role in human malignancies. However, the levels of TP73-AS1 and its functional mechanisms in pancreatic cancer metastasis remain unknown...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (3): BSR20181377.
Published: 15 March 2019
...Jin-yan Wang; Li-juan Chen Cervical cancer (CC) with early metastasis of the primary tumor results in poor prognosis and poor therapeutic outcomes. MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a substantial role in regulating gene expression post-transcriptionally and influence...
Articles
Biosci Rep (2019) 39 (3): BSR20181639.
Published: 06 March 2019
... correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade and lymph node metastasis, but not with age, histological type, and tumor size. Kaplan–Meier survival analysis suggested that high TRIM44 expression was associated with poor prognosis. Patients highly...
Articles
Biosci Rep (2019) 39 (1): BSR20180999.
Published: 11 January 2019
... overexpression was strongly associated with poor clinical outcomes. Then the loss/gain-of-function assays elucidated that TP73-AS1 contributed to cell proliferation, migration, and invasion in vitro , and the in vivo experiments illustrated that its knockdown inhibited tumor growth and metastasis. What was more...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (1): BSR20181165.
Published: 08 January 2019
...Wei Li; Yubo Zhou Intratumoral hypoxia is a well-known feature of solid cancers and constitutes a major contributor to cancer metastasis and poor outcomes including melanoma. Leucine-rich repeats and Ig-like domains 1 (LRIG1) participate in the aggressive progression of several tumors, where its...
Articles
Biosci Rep (2018) 38 (6): BSR20180816.
Published: 30 November 2018
... in IL-6-induced metastasis and EMT in PCa cells through PI3K/PTEN/Akt signaling pathway down-regulating Egr-1 expression. Correspondence: Shengtian Zhao ( zhaost2017@126.com ) 23 05 2018 13 09 2018 17 09 2018 17 10 2018 © 2018 The Author(s). 2018 This is an open...
Articles
Biosci Rep (2018) 38 (5): BSR20180914.
Published: 31 October 2018
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ALDH1 cancer stem cell metastasis NSCLC prognosis Lung cancer accounts for approximately 18% of all cancer deaths worldwide [ 1 ]. Most newly diagnosed lung cancers (75–85...
Articles
Biosci Rep (2018) 38 (5): BSR20180731.
Published: 23 October 2018
... as individualized estimation of clinical outcomes and prognosis. It has already been shown that the epigenetic machinery plays a crucial role in cancer biology, development, and progression. Therefore, we decided to look for metastasis through changes in the most studied epigenetic mark, 5-methylcytosine (m 5 C...
Articles
Biosci Rep (2018) 38 (5): BSR20180677.
Published: 02 October 2018
... LncRNA metastasis miR-26a PCa TUG1 Prostate cancer (PCa) is the second most frequently diagnosed cancer in men that leads to second or third cancer-related deaths worldwide [ 1 ]. Despite improved therapy concept and method, the recurrence of PCa within 5 years remains approximately 25% [ 2...
Articles
Biosci Rep (2018) 38 (5): BSR20180772.
Published: 28 September 2018
...Siying Zhou; Yunjie He; Sujin Yang; Jiahua Hu; Qian Zhang; Wei Chen; Hanzi Xu; Heda Zhang; Shanliang Zhong; Jianhua Zhao; Jinhai Tang Breast cancer (BC) is the most common cancer and principal cause of death among females worldwide. Invasion and metastasis are major causes which influence...
Articles
Biosci Rep (2017) 37 (6): BSR20170837.
Published: 15 December 2017
...Yufeng Zhao; Yuehui Wang; Yaqiang Wang It has been shown that miR-500a may play an important role in the metastasis of hepatocarcinoma. The present study is to explore the influence of miR-500a on hepatocarcinoma proliferation and metastasis, and the related molecular mechanism. The levels of miR...
Articles
Biosci Rep (2017) 37 (6): BSR20171092.
Published: 29 November 2017
... the effects of Wnt5a on tumor growth and metastasis in vivo , A549 cells transfected with sh-Wnt5a were subcutaneously or orthotopically injected into nude mice. In NSCLC tissues, higher expression levels of Wnt5a and ROR2 were found, β-Catenin was expressed exceptionally, and EMT was prompted. Wnt5a...
Articles
Biosci Rep (2017) 37 (4): BSR20170672.
Published: 21 August 2017
...Li-Zhong Lin; Miao-Guo Cai; Yue-Chu Dai; Zhi-Bao Zheng; Fang-Fang Jiang; Li-Li Shi; Yin Pan; Han-Bing Song Our aim is to investigate whether or not the breast cancer metastasis suppressor 1 ( BRMS1 ) gene expression is directly linked to clinico-pathological features of breast cancer. Following...
Articles
Biosci Rep (2017) 37 (4): BSR20170181.
Published: 21 July 2017
...Fei Mi; Liansheng Gong Mesenchymal stem cells (MSCs) interact with tumor cells and regulate tumorigenesis and metastasis. As one of the important components of the tumor microenvironment, MSC-secreted cytokines play a critical role in cancer development. However, whether and how bone marrow MSCs...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (2): BSR20160521.
Published: 15 March 2017
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . epithelial-mesenchymal transition Flot2 microRNA-802 metastasis prostate cancer Prostate cancer (PCa) is the most...