... in its operationalization. In the present study, DNA methylation (DNAm) data (using the Illumina Infinium MethylationEPIC BeadChip (EPIC) array) from the Swiss Kidney Project on Genes in Hypertension (SKIPOGH) cohort, a Swiss-based family cohort study, were used in a discovery epigenome-wide association...

...Catherine Mezzacappa; Zhanwei Wang; Lingeng Lu; Harvey Risch; Tamar Taddei; Herbert Yu Background: Alterations to DNA methylation have been identified in both hepatocellular carcinoma (HCC) tumor and circulating DNA from affected individuals. These markers have potential utility in HCC screening...

... differential gene expression in normal and disease phenotypes. DNA methylation is a significant epigenetic process, guided by DNMT1, one of the most important maintenance methylating agents. However, the relationship between DNMT1 and NTDs had always been inconclusive and poorly understood. In the present...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EMT glioma immune checkpoint immune infiltration methylation RAB34 Glioma is the most frequent primary brain tumor, exhibiting high morbidity, a low rate of healing, and a high relapse rate [ 1...

... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endometrial carcinoma MCM methylation multiomics mutation The prediction of the interaction between miRNA and MCMs was performed with online database, GSCALite ( http://bioinfo.life.hust.edu.cn/web...

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy CRISPR/Caspase-9 glioma methylation TET1 This Retraction...

...Cheng Zhang; Yang Ke; Xuefen Lei; Xin Liu; Hai Li; Runjiao Shi; Lin Wang Objective: The aim of the present study was to explore the relationship among Girdin DNA methylation, its high expression, and immune infiltration in human hepatocellular carcinoma (HCC). Materials and methods: The Cancer...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . In the present study, we applied a DL computational framework based on multiomics data (mRNA data, miRNA data, CpG methylation data, and clinical information) from...

... range of ageing-related pathologies. An electrochemical approach, which adopted three analytical techniques, was used to investigate DNA methylation in the engrailed-1 ( EN1 ) gene promoter. Using synthetic single-stranded DNA, one technique was able to detect DNA at concentrations as low as 10 nM...

...Limin Zhen; Gang Ning; Lina Wu; Yongyuan Zheng; Fangji Yang; Tongtong Chen; Wenxiong Xu; Ying Liu; Chan Xie; Liang Peng Objectives: To identify the prognostic value of aberrantly methylated differentially expressed genes (DEGs) in hepatocellular carcinoma (HCC) and to explore the underlying...

...Xin Zhao; Di Cao; Zhangyong Ren; Zhe Liu; Shaocheng Lv; Jiqiao Zhu; Lixin Li; Ren Lang; Qiang He Background: Hypermethylation of gene promoters plays an important role in tumorigenesis. The present study aimed to identify and validate promoter methylation-driven genes (PMDGs) for pancreatic ductal...

...Weihao Tang; Yiling Cao; Xiaoke Ma Kidney renal clear cell carcinoma (KIRC) is a common tumor with poor prognosis and is closely related to many aberrant gene expressions. DNA methylation is an important epigenetic modification mechanism and a novel research target. Thus, exploring the relationship...

... predicted via miRNet database, and methylation status of promoters of DEGs was determined through UALCAN database. Results: A total of 375 DEGs, including 105 and 270 up-regulated and down-regulated genes in LUAD, were commonly appeared in three datasets. These DEGs were significantly enriched...

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy CRISPR/Caspase-9 glioma methylation TET1 The Editorial...

...Xiaoling Ma; Jinhui Liu; Hui Wang; Yi Jiang; Yicong Wan; Yankai Xia; Wenjun Cheng Methylation functions in the pathogenesis of cervical cancer. In the present study, we applied an integrated bioinformatics analysis to identify the aberrantly methylated and differentially expressed genes (DEGS...

.... Further, though survival analysis, methylation analysis, pivot analysis, and enrichment analysis, some important molecules and related function or pathway were identified to elucidate potential mechanism in esophageal cancer. Results: A total of 7457 DEGs and 14 gene interaction modules were identified...

... was initially identified as a critical transcription factor in various normal tissues, which interacted with serum response factor (SRF) or other substance to regulate normal physiological function. However, HOPX is at a low expression or methylation level in tumors. These data indicated that HOPX may play...

...Yuanli Wang; Wenwen Gong; Shaofang Lv; Hongmei Qu; Yanling He Methylation of hypoxia-inducible factor-3α (HIF3A) was previously demonstrated to be highly associated with insulin resistance (IR) in patients with gestational diabetes mellitus (GDM). We aimed to study the therapeutic effects...

...: changes in the broad range, overlaps with that of blood, and negatively correlates with the increasing tumor grade. Because the amount of m 5 C in tumor tissue and blood is almost identical, the genomic DNA methylation can be a useful marker for brain metastases detection and differentiation. Our research...

... content by HPLC, and methylation levels using BSP+Miseq sequencing in ‘Huangjinlun’ variety during different developmental stages including flower-bud stage (S1), initiating bloom (S2), bloom stage (S3), and withering stage (S4). Results showed that the expression level of CHI gene at S2 stage...

...Qian Feng; Jing Hui; Na Tang; Yong-Min Liu; Hua Zhong; Zhen Li; La-Mei Wang; Yuan-Yuan Qu; Feng-Mei Deng; Fang He Human cytomegalovirus (HCMV) infection, chronic inflammation and oxidative stress, the renin–angiotensin system (RAS), endothelial function, and DNA methylation play roles...

...Rui Fu; Yan Ding; Jie Luo; Li Yu; Cheng Lin Li; Dong Sheng Li; Shi Wen Guo DNA methylation and demethylation play a critical role in the regulation of the molecular pathogenesis of gliomas. Tet methylcytosine dioxygenase 1 (TET1) catalyses the sequential oxidation of 5-methylcytosine (5mC) to 5...

...Hao Zhang; Aimei Li; Wei Zhang; Zhijun Huang; Jianwen Wang; Bin Yi Connective tissue growth factor (CTGF) plays an essential role in the pathogenesis of diabetic nephropathy and we have previously identified that high glucose induced the expression of CTGF by decreasing DNA methylation. The aim...

...Yasahiro Deguchi; Shigeru Negoro; Susumu Kishimoto The degree of methylation at the c-myc proto-oncogene was found to change in human lymphoproliferative diseases, when examined using a methylation-sensitive restriction enzyme. In peripheral blood mononuclear cells (PBMC) c-myc DNA showed...