... both protein and RNA required for cellular respiration. Each cell may contain hundreds to thousands of copies of the mitochondrial genome, which is essential for normal cellular function – deviation of mitochondrial DNA (mtDNA) copy number is associated with cellular ageing and disease. Furthermore...

... horizontal gene transfer innate immune response mtDNA transfusion adverse reaction transfusion Correspondence: Yuanshuai Huang ( [email protected] ) 08 08 2019 18 01 2020 03 03 2020 09 03 2020 © 2020 The Author(s). 2020 This is an open access article published...

... causes of mtDNA variants were not discussed or excluded. Furthermore, conformational changes or impaired stability or mobility of the tRNA molecule not necessarily imply perturbed function of the tRNA [ 5 ]. Overall, this interesting case report has a number of shortcomings, which do not allow...

...Salvatore DiMauro The small, maternally inherited mitochondrial DNA (mtDNA) has turned out to be a hotbed of pathogenic mutations: 15 years into the era of ‘mitochondrial medicine’, over 150 pathogenic point mutations and countless rearrangements have been associated with a variety of multisystemic...

... lateral sclerosis and Huntington's disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration. © 2007 The Biochemical Society 2007 Mitochondria mtDNA Alzheimer's disease Parkinson's disease Amyotrophic lateral sclerosis Huntington's disease...

..., the Department of Neuroscience of the University of Pisa (Italy) has organised a scientific meeting on October 25th, 2006, to discuss recent progress in the field of mitochondriology. © 2007 The Biochemical Society 2007 Mitochondrion mtDNA Mitochondrial diseases ORI GI N A L P A PE R Foreword...

... of these disorders is ample, making a precise diagnosis difficult. We will report some of the major clinical phenotypes observed in infancy, their underlining molecular features, and will propose an approach to reach a more complete diagnosis. © 2007 The Biochemical Society 2007 mtDNA Mitochondrial diseases...

.... Aerobic exercise and physical therapy prevent or correct deconditioning and improve exercise tolerance in patients with mitochondrial myopathies due to mitochondrial DNA (mtDNA) mutations. Gene therapy is a challenge because of polyplasmy and heteroplasmy, but interesting experimental approaches are being...

...Julie L. Gardner; Lyndsey Craven; Douglass M. Turnbull; Robert W. Taylor An extensive range of molecular defects have been identified in the human mitochondrial genome (mtDNA), causing a range of clinical phenotypes characterized by mitochondrial respiratory chain dysfunction. Sadly, given...

...Aya Sato; Hitoshi Endo; Kazuo Umetsu; Hideyuki Sone; Yoshiko Yanagisawa; Azusa Saigusa; Sayuri Aita; Yasuo Kagawa Mitochondrial DNA (mtDNA) is highly susceptible to mutations that result in polymorphisms and diseases including diabetes. We analyzed heteroplasmy, polymorphisms related to diabetes...

... by regulating the intramolecular rotation of F 0 F 1 with the ΔμH + and the inhibitors of the ATPase. B. The roles of the control regions of the F 0 F 1 genes, are to coordinate both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) depending on the energy demand of the cells, especially in muscle. C. The cause...