...Mark A. Valentim; Aditya N. Brahmbhatt; A. Russell Tupling In healthy muscle, the rapid release of calcium ions (Ca 2+ ) with excitation–contraction (E-C) coupling, results in elevations in Ca 2+ concentrations which can exceed 10-fold that of resting values. The sizable transient changes in Ca 2...

...Zan Liu; Xu Cui; Yanke Hu; Pihong Zhang Pressure ulcers (PUs) are a common clinical issue lacking effective treatment and validated pharmacological therapy in hospital settings. Ischemia–reperfusion injury of deep tissue, especially muscle, plays a vital role in the formation and development...

...-ethylhexyl) phthalate (MEHP) once enters organisms. Exposure to DEHP/MEHP through food chain intake has been shown to modified metabolism but its effect on the development of metabolic myopathy of skeletal muscle (SKM) has not been revealed so far. Here, we found that MEHP repressed myogenic terminal...

... muscle MyoD myogenesis Pax7 Wnt3a 17 11 2014 27 1 2015 4 2 2015 5 2 2015 The expression pattern of human MyoD during embryogenesis can be recapitulated by the upstream 24 kb flanking sequence, and several major cis -elements within this region regulating MyoD...

..., is expressed ubiquitously in various tissues but with higher expression levels in oxidative tissues, such as brain and oxidative muscles. Both the expression level and promoter activity of FoxO6 were found to be enhanced by PGC-1α (peroxisome-proliferator-activated receptor γ co-activator 1α), thus explained...

...C. A. Maltin; M. I. Delday; S. M. Hay; F. G. Smith; G. E. Lobley; P. J. Reeds The dietary administration of clenbuterol to young male rats has been shown to produce a muscle specific hypertrophic growth response. This paper demonstrates that the combined effect of drug treatment and hypertrophic...

...C. A. Maltin; M. I. Delday; S. M. Hay; F. G. Smith; P. J. Reeds The effect of propranolol on clenbuterol-induced changes in muscle fibre size and protein content were studied. Propranolol did not inhibit the ability of clenbuterol to stimulate protein accretion but reduced the increase in muscle...

...C. A. Maltin; P. J. Reeds; M. I. Delday; S. M. Hay; F. G. Smith; G. E. Lobley Dietary administration of the growth promoter, clenbuterol, ameliorated denervation-induced atrophy in rat soleus muscles. In acutely denervated muscles the drug inhibited the appearance of atrophy, and in chronically...

...Moses Agbanyo; Norman F. Taylor Flight muscle and fat body extracts from Locusta migratoria were incubated with D-[U- 14 C]-glucose or D-[3- 3 H]-3-deoxy-3-fluoroglucose and the products were analyzed. In the case of the latter compound, radio-chromatographic analysis yielded glycogen and trehalose...

...V. R. Preedy; P. J. Garlick In 12 h fasted rats, rates of muscle protein synthesis were stimulated by refeeding for 1 h and by intragastric or intravenous infusion of an amino acid plus glucose mixture for 1 hr, but not by intravenous infusion of amino acids alone for 1 h. Intravenous injection...

...P. J. Reeds; R. M. Palmer; S. M. Hay; D. N. McMillan Six groups of 5 male rats (starting body weight 109 g) were allowed free access to a conventional rat diet. At 4 hourly intervals, starting at 10.00 h muscle protein synthesis was measured. By relating the weights of the gastrocnemius and soleus...

...M. A. Aleixandre; E. Ayala; P. Garcia de Jalón The effect of potassium on the longitudinal muscle-myenteric plexus (LM-MP) preparation from guinea-pig was studied. The strips were exposed to elevated K + (30 m M , 60 m M , 90 m M , 120 m M or 150 m M ). A phasic contraction of the LM-MP was caused...