... tumour xenograft model. A single intraperitoneal injection of placental EVs at 15 days post tumour implantation, significantly inhibited the growth of the tumours in our in vivo model. Signs of cellular necrosis were observed in the ovarian tumour tissues, but not in other organs collected from mice...

... signalling colocalization necrosis regucalcin Doxorubicin (DOX) is a potent anticancer drug, which consists of an amino-sugar daunosamine bound to a tetracycline moiety [ 1 ]. Biochemically, DOX reacts and interferes with DNA and DNA polymerases at G1 and G2 phases of the cell cycle, inhibiting...

... in patients with LGG. Methods: Clinical data of 80 patients with pathologically proved LGGs between January 2010 and December 2016 were analyzed retrospectively. MRI features were classified as contrast enhancement pattern (focal enhancement, diffuse enhancement and ring-like enhancement), necrosis and cysts...

... Lfcins. Lfampin killed 80% of trophozoites at doses higher than 100 μM in 24 h, and FACs analysis using Annexin V/propidium iodide showed that death occurred mainly by necrosis. In contrast, Lfcin-B and Lfcin 17-30 appeared to have no significant effect on amoebic viability. FACs and confocal microscopy...

...Xiaoyi Yang; Yuzhong Zhang; Youguo Huang; Fuyu Yang While Ca 2+ has been proposed to be a messenger in OxLDL-induced cell death, few studies have addressed the possibility that it may influence the occurrence of apoptosis and necrosis of macrophages induced by OxLDL in virtue of change...

...Johannes B. Prins; Elizabeth C. Ledgerwood; Paul Ameloot; Peter Vandenabeele; Paulo R. Faraco; Nicholas A. Bright; Stephen O'Rahilly; John R. Bradley Tumor necrosis factor (TNF) may cause apoptosis or necrosis and induces mitochondrial changes that have been proposed to be central to cytotoxicity...

... necrosis mitochondria megachannel permeability transition programmed cell death poteases Bioscience Reports, Vol. 17, No. 1, 1997 REVIEW Role of the Mitochondrial Permeability Transition Pore in Apoptosis Tamara Hirsch,1 Isabel Marzo,1 and Guido Kroemer1*2 Received October 21, 1996 Mitochondrial...