... of their paper. © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . astrocytes neurodegeneration neurogeneration transcription factors...

...; conversely small interfering RNA knockdown of AQP0 in 1321N1 increased lipid peroxidation (∼17%) after H 2 O 2 , with a similar trend for AQP11 siRNA. Interventions that increase native brain peroxiporin activity are promising as new approaches to mitigate damage caused by aging and neurodegeneration...

... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . astrocytes neurodegeneration neuroregeneration transcription factors The National Natural Science Foundation...

... and neurodegeneration. The pathological symptoms of cognitive damage, such as memory loss, cognitive decline and other neurological dysfunctions are the result of inflammation, and oxidative stress ( Figure 2 ). Lohr et al. also concluded a definitive cure to PBA, since the lesions formed are localized as compared...

... Attribution License 4.0 (CC BY) . endoplasmic reticulum endosomes intracellular transport Lysosomes neurodegeneration neuronal ceroid lipofuscinosis First discovered by Christian de Duve, lysosomes perform several key cellular functions, and their dysfunction has been implicated in several...

... and the Biochemical Society under a transformative agreement with JISC. Caenorhabditis elegans Functional Modelling GWAS leucine rich repeat kinase neurodegeneration Parkinson’s disease Parkinson’s disease (PD) is a common, progressive and multi-system neurodegenerative disorder, for which...

... 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alzheimer's disease disease models neurodegeneration tau protein...

.... Such understanding may have further implications in neurodegeneration and peripheral neuropathy. Expression and purification of maltose-binding protein (MBP)-TRPV2-Ct (C-terminal cytoplasmic domain of TRPV2 fused with MBP) and as MBP-LacZ (LacZ fused with MBP) was based on a protocol described previously [ 20...

... celiac disease cardiac disease neurodegeneration tranglutaminase Cystamine is a symmetric organodisulphide commonly used as an inhibitor of transglutaminases. This disulphide is also reduced to cysteamine within the body. Cystamine and cysteamine both inhibit transglutaminases but by different...

... of phosphatidylinositol 3,5-bisphosphate [PI(3,5) P 2 ]. PIKfyve function is required for homoeostasis of the endo/lysosomal system and is crucially implicated in neuronal function and integrity, as loss of function mutations in the PIKfyve complex lead to neurodegeneration in mouse models and human patients. Our recent...

... mitochondria neurodegeneration subcellular-fractionation vitamin B 12 © 2014 The author(s) 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution...

...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cognition diabetes energy homoeostasis ghrelin hormone insulin leptin neural circuitry neurodegeneration Food intake...

... in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in neurodegeneration?” is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic...

.... Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene–environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human...

... involved in both neurodegeneration and cancer. An impairment of Wnt signals appears to be associated with aspects of neurodegenerative pathologies while overactivation of Wnt signaling is a common theme in several types of human tumors. Therefore, although therapeutic approaches aimed at modulating Wnt...

...+ . These results suggest that Aβ 25–35 can promote the PTP induced by Ca 2+ . © 2001 Plenum Publishing Corporation 2001 Amyloid β-peptide permeability transition pore brain mitochondria mitochondrial transmembrane potential calcium fluxes neurodegeneration Bioscience Reports, Vol. 21, No. 6...