...Kangzhe Xie; Jordan Hunter; Aaron Lee; Gulfam Ahmad; Paul K. Witting; Tamara Ortiz-Cerda Inflammatory bowel disease (IBD) is a gastrointestinal disorder characterised by elevated colonic neutrophil extracellular traps (NETs), which are associated with disease severity. Formation of NETs...

...César Díaz-Godínez; Julio C. Carrero Neutrophil extracellular traps (NETs) are DNA fibers associated with histones, enzymes from neutrophil granules and anti-microbial peptides. NETs are released in a process denominated NETosis, which involves sequential steps that culminate with the DNA extrusion...

...) their release after plaque disruption with percutaneous coronary intervention (PCI). MP are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. Neutrophils play a role in plaque destabilization and shed neutrophil...

...Lena Völlger; Kathryn Akong-Moore; Linda Cox; Oliver Goldmann; Yanming Wang; Simon T. Schäfer; Hassan Y. Naim; Victor Nizet; Maren von Köckritz-Blickwede Neutrophil extracellular trap (NET) formation is a significant innate immune defense mechanism against microbial infection that complements other...

...Per-Arne Oldenborg; Janove Sehlin The response to D-glucose (0–21 mM) was studied in neutrophil granulocytes from obese, hyperglycemic and hyperinsulinemic Umeå ob/ob mice and their lean, littermate controls in order to further elucidate the effects of in vivo and in vitro hyperglycemia...

...Steven W. Edwards; Fiona Watson; Ronald MacLeod; John Davies Incubation of human bloodstream neutrophils with 50 u/ml recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) “primed” the respiratory burst (as assessed by fMet-Leu-Phe stimulated luminol-dependent chemiluminescence...

...Valerie Hughes; John M. Humphreys; Steven W. Edwards Circulating human neutrophils exhibited low rates of protein biosynthesis, as determined by their ability to incorporate [ 35 S]methionine into TCA-precipitable material. Exposure of cells to the chemotactic peptide (N-formyl-L-methionyl-L-leucyl...

...Steven W. Edwards; David Lloyd Room temperature, CO-difference spectra of intact rat polymorphonuclear leucocytes (neutrophils) revealed the presence of a number of CO-binding haemoproteins. Absorption maxima at 413, 540 and 570 nm were attributed to the CO-complex of cytochrome b -245 whereas...

...Steven W. Edwards; David Lloyd We have made simultaneous spectrophotometric and O 2 measurements on suspensions of rat neutrophils during activation of the respiratory burst. Under aerobic conditions an absorption increase attributable to myeloperoxidase compound II was observed in parallel...