... because of its lower possibility of affecting fetal growth. Therefore, we examined the isoflurane anesthesia-induced effects on maternal hemodynamic and vascular changes. We hypothesized that isoflurane would enhance endothelium-dependent vasodilation as a consequence of increased nitric oxide...

.... The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of proline residues and subsequent proteasomal degradation. Studies from our laboratory revealed that nitric oxide (NO)-mediated activation of cyclic guanosine monophosphate (cGMP...

... impaired nitric oxide and insulin activity and furthermore dermcidin was also found in a few types of cancer patients. To determine the role of this protein in prostatic malignancy, a retrospective case–control study was conducted and blood was collected from prostate cancer patients and healthy normal...

...Ellen E. Gillis; Krystal N. Brinson; Olga Rafikova; Wei Chen; Jacqueline B. Musall; David G. Harrison; Jennifer C. Sullivan We previously published that female spontaneously hypertensive rats (SHR) have significantly greater nitric oxide (NO) bioavailability and NO synthase (NOS) enzymatic activity...

... resulted in reduced reactive oxygen species level, and it increased tube formation, nitric oxide (NO), and cGMP level. Moreover, miR-133a antagonism-induced angiogenesis was abolished by GCH1 inhibitor. In contrary, miR-133a overexpression impairs angiogenesis and it reduces GCH1, NO, and cGMP levels...

... that NO (nitric oxide)-releasing compounds induce 5-oxo-ETE synthesis in neutrophils treated with OZ or S. typhimurium. Exposure of neutrophils to zymosan or bacteria in the presence of the NO donor DEA NONOate (1,1-diethyl-2-hydroxy-2-nitroso-hydrazine sodium) considerably increased the conversion...

... Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited cytotoxicity hypoxia nitric oxide S-nitrosylation NO is a stable-free radical...

...) and GCs (guanylate cyclases) comprise transmembrane receptors as well as soluble isoforms. Whereas sGC (soluble GC) has a well-characterized regulatory HD (haem domain) that acts as a receptor for the activator NO (nitric oxide), very little is known about the regulatory domains of the ubiquitous...

... on RhoA expression under a stress state in rat VSMCs (vascular smooth muscle cells) and the underlying mechanisms. The expression of iNOS (inducible nitric oxide synthase) and iNOS activity as well as NO concentration was significantly promoted by LPS (lipopolysaccharide) accompanying the elevation...

... paramagnetic resonance; also known as ESR (electron spin resonance)) was used to identify FRs (free radicals). These results were subsequently correlated with SOD (superoxide dismutase) catalytic activity, iNOS [inducible NOS (nitric oxide synthase) or NOSII] expression and NO (nitric oxide) content. EPR...

...Dayane Aparecida Gomes; Alexandre Giusti-Paiva; Renato Rizo Ventura; Lucila Leico Kagohara Elias; Fernando Queiroz Cunha; Jose Antunes-Rodrigues OT (oxytocin) is secreted from the posterior pituitary gland, and its secretion has been shown to be modulated by NO (nitric oxide). In rats, OT secretion...

...Ferid Murad The role of nitric oxide in cellular signaling in the past 22 years has become one of the most rapidly growing areas in biology with more than 20,000 publications to date. Nitric oxide is a gas and free radical with an unshared electron that can regulate an ever-growing list...

...Robert F. Furchgott The discovery, early studies and identification of endothelium-derived relaxing factor (EDRF) as nitric oxide, are described. © 1999 Plenum Publishing Corporation 1999 Endothelium derived relaxing factor (EDRF) nitric oxide Bioscience Reports, Vol. 19, No. 4, 1999...

...Ferid Murad The role of nitric oxide in cellular signaling in the past 22 years has become one of the most rapidly growing areas in biology with more than 20,000 publications to date. Nitric oxide is a gas and free radical with an unshared electron that can regulate an ever-growing list...

...Louis J. Ignarro The properties of nitric oxide as an endogenous cell signaling molecule in vascular biology are described. © 1999 Plenum Publishing Corporation 1999 Cell signaling nitric oxide vasculation Bioscience Reports, Vol. 19, No. 2, 1999 Nobel Lecture December 8, 1998 Nitric...

... 1994 Plenum Publishing Corporation 1994 interleukin-1 nitric oxide insulin tyrosine kinase phosphatase Bioscience Reports, Vol. 14, No. 1, 1994 A in Interleukin-1/3 Production in the Line RINm-5F Role for Tyrosine Kinase Activation Induced Nitric Oxide Insulin Producing Cell Nils Welsh I...

...R. J. Bing; A. Termin; A. Conforto; R. Dudek; M. J. Hoffmann This communication examines the possibility that nitric oxide (NO) production by endothelial cells results from changes in cell membrane fluidity. Lysophosphatidylcholine (LPC) alters fluidity of the endothelial cell membranes causing...

... contact, have been found to affect bone resorption profoundly. For instance, the autocoid nitric oxide strongly inhibits bone resorption. Finally, reactive oxygen species have been found to aid bone resorption and enhance osteoclastic activity directly. Here, we will attempt to integrate these control...