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Keywords: nucleus pulposus
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Articles

Retraction: Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-1726_RET.
https://doi.org/10.1042/BSR-2019-1726_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Fas/FasL nucleus pulposus TGF-β1 TNF-α This article is one...
View article titled, Retraction: Transforming growth factor-β1-regulated Fas&#x2F;FasL pathway activation suppresses <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis in an inflammatory environment
Open the PDF for Retraction: Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis in an inflammatory environment in another window
Articles

Retraction: Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-0670_RET.
https://doi.org/10.1042/BSR-2018-0670_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell senescence compression nucleus pulposus nucleus pulposus resveratrol...
View article titled, Retraction: <span class="search-highlight">Nucleus</span> <span class="search-highlight">pulposus</span> cell senescence is alleviated by resveratrol through regulating the ROS&#x2F;NF-κB pathway under high-magnitude compression
Open the PDF for Retraction: <span class="search-highlight">Nucleus</span> <span class="search-highlight">pulposus</span> cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression in another window
Articles

Retraction: Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-0170_RET.
https://doi.org/10.1042/BSR-2019-0170_RET
Published: 22 August 2024
... ) The authors have been contacted in regard to the retraction, and have not responded to the Journal. Given the extent of the issues raised, the Editorial Board stand by the decision to retract the article. apoptosis high glucose intervertebral disc degeneration nucleus pulposus osteogenic protein-1...
View article titled, Retraction: Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells
Open the PDF for Retraction: Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells in another window
Articles

Retraction: Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyper-osmotic environment

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-1176_RET.
https://doi.org/10.1042/BSR-2018-1176_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis CDMP-2 intervertebral disc degeneration nucleus pulposus...
View article titled, Retraction: <span class="search-highlight">Nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyper-osmotic environment
Open the PDF for Retraction: <span class="search-highlight">Nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyper-osmotic environment in another window
Articles

Retraction: Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of nucleus pulposus cells under high-magnitude compression though inhibiting the p38 MAPK pathway

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-0018_RET.
https://doi.org/10.1042/BSR-2018-0018_RET
Published: 22 August 2024
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis compression matrix nucleus pulposus osteogenic protein-1 This article is one of twenty-five publications being retracted from Bioscience Reports...
View article titled, Retraction: Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells under high-magnitude compression though inhibiting the p38 MAPK pathway
Open the PDF for Retraction: Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells under high-magnitude compression though inhibiting the p38 MAPK pathway in another window
Articles

Retraction: Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-1711_RET.
https://doi.org/10.1042/BSR-2019-1711_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . intervertebral disc nucleus pulposus osmolarity oxidative stress...
View article titled, Retraction: Hyper-osmolarity environment-induced oxidative stress injury promotes <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in vitro
Open the PDF for Retraction: Hyper-osmolarity environment-induced oxidative stress injury promotes <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in vitro in another window
Articles

Retraction: Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MPAK pathway

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-1451_RET.
https://doi.org/10.1042/BSR-2018-1451_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . intervertebral disc degeneration nucleus pulposus p38 MAPK pH senescence...
View article titled, Retraction: Acidic pH promotes <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence through activating the p38 MPAK pathway
Open the PDF for Retraction: Acidic pH promotes <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence through activating the p38 MPAK pathway in another window
Articles

Retraction: Resveratrol increases nucleus pulposus matrix synthesis through activating the PI3K/Akt signaling pathway under mechanical compression in a disc organ culture

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2017-1319_RET.
https://doi.org/10.1042/BSR-2017-1319_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . matrix mechanical compression nucleus pulposus resveratrol...
View article titled, Retraction: Resveratrol increases <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> matrix synthesis through activating the PI3K&#x2F;Akt signaling pathway under mechanical compression in a disc organ culture
Open the PDF for Retraction: Resveratrol increases <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> matrix synthesis through activating the PI3K/Akt signaling pathway under mechanical compression in a disc organ culture in another window
Articles

Retraction: Osteogenic protein-1 inhibits nucleus pulposus cell apoptosis through regulating the NF-κB/ROS pathway in an inflammation environment

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-1530_RET.
https://doi.org/10.1042/BSR-2018-1530_RET
Published: 22 August 2024
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis disc degeneration nucleus pulposus osteogenic protein-1 TNF-α ...
View article titled, Retraction: Osteogenic protein-1 inhibits <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the NF-κB&#x2F;ROS pathway in an inflammation environment
Open the PDF for Retraction: Osteogenic protein-1 inhibits <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the NF-κB/ROS pathway in an inflammation environment in another window
Articles

Retraction: The response of nucleus pulposus cell senescence to static and dynamic compressions in a disc organ culture

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-0064_RET.
https://doi.org/10.1042/BSR-2018-0064_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . compression degeneration nucleus pulposus organ culture senescence...
View article titled, Retraction: The response of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence to static and dynamic compressions in a disc organ culture
Open the PDF for Retraction: The response of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence to static and dynamic compressions in a disc organ culture in another window
Articles

Retraction: Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-1708_RET.
https://doi.org/10.1042/BSR-2018-1708_RET
Published: 22 August 2024
... cell apoptosis intervertebral disc degeneration nucleus pulposus osteogenic protein-1 PI3K/Akt/mTOR This article is one of twenty-five publications being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt...
View article titled, Retraction: Osteogenic protein-1 attenuates <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through activating the PI3K&#x2F;Akt&#x2F;mTOR pathway in a hyperosmotic culture
Open the PDF for Retraction: Osteogenic protein-1 attenuates <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture in another window
Articles

Retraction: Role of p38-MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2017-0718_RET.
https://doi.org/10.1042/BSR-2017-0718_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . compression interverbral disc nucleus pulposus p38-MAPK senescence...
View article titled, Retraction: Role of p38-MAPK pathway in the effects of high-magnitude compression on <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in a disc perfusion culture
Open the PDF for Retraction: Role of p38-MAPK pathway in the effects of high-magnitude compression on <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in a disc perfusion culture in another window
Articles

Retraction: Bone morphogenetic protein-7 retards cell subculture-induced senescence of human nucleus pulposus cells through activating the PI3K/Akt pathway

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-2312_RET.
https://doi.org/10.1042/BSR-2018-2312_RET
Published: 22 August 2024
... degeneration nucleus pulposus This article is one of twenty-five publications being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting the Editorial Office to suspected misconduct in three...
View article titled, Retraction: Bone morphogenetic protein-7 retards cell subculture-induced senescence of human <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells through activating the PI3K&#x2F;Akt pathway
Open the PDF for Retraction: Bone morphogenetic protein-7 retards cell subculture-induced senescence of human <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells through activating the PI3K/Akt pathway in another window
Articles

Retraction: Resveratrol attenuates mechanical compression-induced nucleus pulposus cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2017-1703_RET.
https://doi.org/10.1042/BSR-2017-1703_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis intervertebral disc degeneration nucleus pulposus resveratrol...
View article titled, Retraction: Resveratrol attenuates mechanical compression-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the ERK1&#x2F;2 signaling pathway in a disc organ culture
Open the PDF for Retraction: Resveratrol attenuates mechanical compression-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture in another window
Articles

Retraction: Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of nucleus pulposus cells in a disc bioreactor culture

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2016-0582_RET.
https://doi.org/10.1042/BSR-2016-0582_RET
Published: 22 August 2024
... degeneration N-cadherin nucleus pulposus organ culture This article is one of twenty-five publications being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting the Editorial...
View article titled, Retraction: Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells in a disc bioreactor culture
Open the PDF for Retraction: Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells in a disc bioreactor culture in another window
Articles

Retraction: Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-2462_RET.
https://doi.org/10.1042/BSR-2018-2462_RET
Published: 22 August 2024
... apoptosis mechanical overload mechano growth factor nucleus pulposus This article is one of twenty-five publications being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting...
View article titled, Retraction: Mechano growth factor attenuates mechanical overload-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through inhibiting the p38 MAPK pathway
Open the PDF for Retraction: Mechano growth factor attenuates mechanical overload-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through inhibiting the p38 MAPK pathway in another window
Articles

Retraction: Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2017-1454_RET.
https://doi.org/10.1042/BSR-2017-1454_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis glucose intervertebral disc degeneration nucleus pulposus...
View article titled, Retraction: Resveratrol attenuates high glucose-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis and senescence through activating the ROS-mediated PI3K&#x2F;Akt pathway
Open the PDF for Retraction: Resveratrol attenuates high glucose-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway in another window
Articles

Retraction: Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of nucleus pulposus cells in a disc perfusion culture

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2017-1551_RET.
https://doi.org/10.1042/BSR-2017-1551_RET
Published: 22 August 2024
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . compression degeneration N-cadherin nucleus pulposus organ culture ...
View article titled, Retraction: Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells in a disc perfusion culture
Open the PDF for Retraction: Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells in a disc perfusion culture in another window
Articles

Retraction: Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-0126_RET.
https://doi.org/10.1042/BSR-2019-0126_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell senescence intervertebral disc degeneration nucleus pulposus...
View article titled, Retraction: Resveratrol attenuates inflammation environment-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in vitro
Open the PDF for Retraction: Resveratrol attenuates inflammation environment-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in vitro in another window
Articles

Retraction: Resveratrol enhances matrix biosynthesis of nucleus pulposus cells through activating autophagy via the PI3K/Akt pathway under oxidative damage

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-0544_RET.
https://doi.org/10.1042/BSR-2018-0544_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy intervertebral disc degeneration nucleus pulposus resveratrol...
View article titled, Retraction: Resveratrol enhances matrix biosynthesis of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells through activating autophagy via the PI3K&#x2F;Akt pathway under oxidative damage
Open the PDF for Retraction: Resveratrol enhances matrix biosynthesis of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells through activating autophagy via the PI3K/Akt pathway under oxidative damage in another window
Articles

Retraction: Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway

Journal: Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-0043_RET.
https://doi.org/10.1042/BSR-2019-0043_RET
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis IL-1β intervertebral disc degeneration nucleus pulposus...
View article titled, Retraction: Resveratrol inhibits IL-1β-mediated <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the PI3K&#x2F;Akt pathway
Open the PDF for Retraction: Resveratrol inhibits IL-1β-mediated <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the PI3K/Akt pathway in another window
Articles

Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment

Jingjing Xie, Bo Li, Bing Yao, Pingchao Zhang, Lixin Wang, Hua Lu, Xuan Song
Journal: Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20191726.
https://doi.org/10.1042/BSR20191726
Published: 04 February 2020
...Jingjing Xie; Bo Li; Bing Yao; Pingchao Zhang; Lixin Wang; Hua Lu; Xuan Song Background: During disc degeneration, inflammatory cytokine tumor necrosis factor (TNF)-α is correlated with nucleus pulposus (NP) cell apoptosis. Transforming growth factor (TGF)-β1 has the potential to regenerate...
View article titled, Transforming growth factor-β1-regulated Fas&#x2F;FasL pathway activation suppresses <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis in an inflammatory environment
Open the PDF for Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis in an inflammatory environment in another window
Articles

Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro

Jiawei Xu, Haopeng Li, Kai Yang, Shuai Guo, Jie Wang, Chaoshuai Feng, Huayou Chen
Journal: Bioscience Reports
Biosci Rep (2019) 39 (9): BSR20191711.
https://doi.org/10.1042/BSR20191711
Published: 20 September 2019
...Jiawei Xu; Haopeng Li; Kai Yang; Shuai Guo; Jie Wang; Chaoshuai Feng; Huayou Chen Nucleus pulposus (NP) cell senescence is involved in disc degeneration. The in situ osmolarity within the NP region is an important regulator of disc cell’s biology. However, its effects on NP cell senescence remain...
View article titled, Hyper-osmolarity environment-induced oxidative stress injury promotes <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in vitro
Open the PDF for Hyper-osmolarity environment-induced oxidative stress injury promotes <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in vitro in another window
Articles

Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro

Xiaoming Li, Feixiang Lin, Yaohong Wu, Ning Liu, Jun Wang, Rongchun Chen, Zhijun Lu
Journal: Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20190126.
https://doi.org/10.1042/BSR20190126
Published: 10 May 2019
... with disc cell senescence. Resveratrol has a protective role against inflammation in some cells. However, its biological effects on disc cells remain largely unclear. The present study was aimed to study the effects of resveratrol on disc nucleus pulposus (NP) cell senescence in an inflammation environment...
View article titled, Resveratrol attenuates inflammation environment-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in vitro
Open the PDF for Resveratrol attenuates inflammation environment-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in vitro in another window
Articles

Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells

Ziming Liu, Zhiwen Zhang, Ali Zhang, Fan Zhang, Wennan Du, Yongqiang Zhang, Rongfeng Zhang, Jiagang Xu, Xiangkun Wu, Chengmin Zhang, Ning Li, Qi Tan, Wei Huang
Journal: Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20190170.
https://doi.org/10.1042/BSR20190170
Published: 02 April 2019
... growth factor, osteogenic protein-1 (OP-1) has lots of protective effects on the healthy disc cell’s biology. The present study was aimed to investigate the effects of OP-1 on degenerative changes of nucleus pulposus (NP) cells in a high glucose culture. Rat NP cells were cultured in the baseline medium...
View article titled, Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells
Open the PDF for Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells in another window
Articles

Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway

Qing Xu, Haolin Fang, Liang Zhao, Cunxin Zhang, Luo Zhang, Baofang Tian
Journal: Bioscience Reports
Biosci Rep (2019) 39 (3): BSR20182462.
https://doi.org/10.1042/BSR20182462
Published: 29 March 2019
... of chondrocytes. The present study is aimed to investigate whether MGF can attenuate mechanical overload-induced nucleus pulposus (NP) cell apoptosis and the possible signaling transduction pathway. Rat NP cells were cultured and subjected to mechanical overload for 7 days. The control NP cells did not experience...
View article titled, Mechano growth factor attenuates mechanical overload-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through inhibiting the p38 MAPK pathway
Open the PDF for Mechano growth factor attenuates mechanical overload-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through inhibiting the p38 MAPK pathway in another window
Articles

Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway

Yanhai Jiang, Zhijie Xie, Jinying Yu, Lianqiang Fu
Journal: Bioscience Reports
Biosci Rep (2019) 39 (3): BSR20190043.
https://doi.org/10.1042/BSR20190043
Published: 26 March 2019
...Yanhai Jiang; Zhijie Xie; Jinying Yu; Lianqiang Fu Nucleus pulposus (NP) cell apoptosis is a classical cellular character during intervertebral disc degeneration (IDD). Previous studies have shown that inflammatory cytokine-induced NP cell apoptosis plays an important role in disc degeneration...
View article titled, Resveratrol inhibits IL-1β-mediated <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the PI3K&#x2F;Akt pathway
Open the PDF for Resveratrol inhibits IL-1β-mediated <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the PI3K/Akt pathway in another window
Articles

Bone morphogenetic protein-7 retards cell subculture-induced senescence of human nucleus pulposus cells through activating the PI3K/Akt pathway

Chen Gong, Wei Pan, Wei Hu, Liang Chen
Journal: Bioscience Reports
Biosci Rep (2019) 39 (3): BSR20182312.
https://doi.org/10.1042/BSR20182312
Published: 19 March 2019
... senescence of human disc cells during cell subculture is important for TE-based strategy to regenerate degenerative disc tissue. Objective: The present study was aimed to investigate whether bone morphogenetic protein-7 (BMP-7) can alleviate subculture-induced senescence of human nucleus pulposus (NP) cells...
View article titled, Bone morphogenetic protein-7 retards cell subculture-induced senescence of human <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells through activating the PI3K&#x2F;Akt pathway
Open the PDF for Bone morphogenetic protein-7 retards cell subculture-induced senescence of human <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells through activating the PI3K/Akt pathway in another window
Articles

Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture

Yan Yang, Xiyang Wang, Zheng Liu, Xiao Xiao, Wenkai Hu, Zhicheng Sun
Journal: Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181708.
https://doi.org/10.1042/BSR20181708
Published: 14 December 2018
... for the application of OP-1 in retarding/regenerating disc degeneration. Correspondence: Xiyang Wang ( [email protected] ) cell apoptosis intervertebral disc degeneration nucleus pulposus osteogenic protein-1 PI3K/Akt/mTOR Low back pain is a common and costly physical disease around the world...
View article titled, Osteogenic protein-1 attenuates <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through activating the PI3K&#x2F;Akt&#x2F;mTOR pathway in a hyperosmotic culture
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Articles

Osteogenic protein-1 inhibits nucleus pulposus cell apoptosis through regulating the NF-κB/ROS pathway in an inflammation environment

Wei Yu, Jiabin Fu, Yan Liu, Yuchi Wu, Dianming Jiang
Journal: Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181530.
https://doi.org/10.1042/BSR20181530
Published: 21 November 2018
...Wei Yu; Jiabin Fu; Yan Liu; Yuchi Wu; Dianming Jiang Background: Intervertebral disc degeneration is a pathological process that involves an inflammation response. As a classical cellular feature, several studies have demonstrated that inflammation can promote nucleus pulposus (NP) cell apoptosis...
View article titled, Osteogenic protein-1 inhibits <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the NF-κB&#x2F;ROS pathway in an inflammation environment
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Articles

Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MAPK pathway

Jiabin Fu, Wei Yu, Dianming Jiang
Journal: Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181451.
https://doi.org/10.1042/BSR20181451
Published: 14 November 2018
...Jiabin Fu; Wei Yu; Dianming Jiang Background: Nucleus pulposus (NP) cell senescence is an important cellular feature within the degenerative disc. It is known that a very acidic niche exists in the degenerative disc, which participates in regulating disc cell viability and matrix metabolism...
View article titled, Acidic pH promotes <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence through activating the p38 MAPK pathway
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Articles

Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyperosmotic environment

Shouguo Jiao, Jingxiang Li, Binbin Liu, Ming Yang, Jiangli Xiu, Daokui Qu
Journal: Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20181176.
https://doi.org/10.1042/BSR20181176
Published: 10 October 2018
...Shouguo Jiao; Jingxiang Li; Binbin Liu; Ming Yang; Jiangli Xiu; Daokui Qu Disc nucleus pulposus (NP) cell experiences periodic osmolarity alterations during daily activities, which has been proved to affect cell biology in vitro . The present study was aimed to investigate the effects of cartilage...
View article titled, <span class="search-highlight">Nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyperosmotic environment
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Articles

Resveratrol enhances matrix biosynthesis of nucleus pulposus cells through activating autophagy via the PI3K/Akt pathway under oxidative damage

Jinlou Gao, Qingyun Zhang, Lin Song
Journal: Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180544.
https://doi.org/10.1042/BSR20180544
Published: 06 July 2018
...Jinlou Gao; Qingyun Zhang; Lin Song The decrease in nucleus pulposus (NP) matrix production is a classic feature during disc degeneration. Resveratrol (RSV) is reported to play protective effects under many pathological factors.The present study aims to study the effects of RSV on NP matrix...
View article titled, Resveratrol enhances matrix biosynthesis of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells through activating autophagy via the PI3K&#x2F;Akt pathway under oxidative damage
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Articles

Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression

Yanhai Jiang, Guozhang Dong, Yeliang Song
Journal: Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180670.
https://doi.org/10.1042/BSR20180670
Published: 06 July 2018
... nucleus pulposus (NP) cell senescence in vitro and the potential mechanism. The isolated rat NP cells were seeded in the decalcified bone matrix (DBM) and cultured under non-compression (control) and compression (20% deformation, 1.0 Hz, 6 h/day) for 5 days using the mechanically active bioreactor...
View article titled, <span class="search-highlight">Nucleus</span> <span class="search-highlight">pulposus</span> cell senescence is alleviated by resveratrol through regulating the ROS&#x2F;NF-κB pathway under high-magnitude compression
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Articles

Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway

Wenping Wang, Pei Li, Jiagang Xu, Xiangkun Wu, Zhiliang Guo, Lijing Fan, Ruipeng Song, Jianli Wang, Li Wei, Haijun Teng
Journal: Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171454.
https://doi.org/10.1042/BSR20171454
Published: 13 April 2018
...Wenping Wang; Pei Li; Jiagang Xu; Xiangkun Wu; Zhiliang Guo; Lijing Fan; Ruipeng Song; Jianli Wang; Li Wei; Haijun Teng Background: Diabetes mellitus is closely correlated with disc degeneration. Nucleus pulposus (NP) cell apoptosis and senescence are typical cellular features within...
View article titled, Resveratrol attenuates high glucose-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis and senescence through activating the ROS-mediated PI3K&#x2F;Akt pathway
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Articles

Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of nucleus pulposus cells under high magnitude compression though inhibiting the p38 MAPK pathway

Haolin Fang, Xianzhou Li, Haiming Shen, Buwei Sun, Haijun Teng, Pei Li
Journal: Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20180018.
https://doi.org/10.1042/BSR20180018
Published: 16 March 2018
...Haolin Fang; Xianzhou Li; Haiming Shen; Buwei Sun; Haijun Teng; Pei Li Disc degeneration is correlated with mechanical load. Osteogenic protein-1 (OP-1) is potential to regenerate degenerative disc. To investigate whether OP-1 can protect against high magitude compression-induced nucleus pulposus...
View article titled, Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells under high magnitude compression though inhibiting the p38 MAPK pathway
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Articles

Resveratrol attenuates mechanical compression-induced nucleus pulposus cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture

Zhiwen Zhang, Feng Wen, Chengjian He, Jun Yu
Journal: Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171703.
https://doi.org/10.1042/BSR20171703
Published: 09 March 2018
...Zhiwen Zhang; Feng Wen; Chengjian He; Jun Yu Background: Nucleus pulposus (NP) cell apoptosis is a typical feature within the degenerative disc. High magnitude compression significantly promotes NP cell apoptosis. Several studies have indicated that resveratrol has protective effects on disc cell’s...
View article titled, Resveratrol attenuates mechanical compression-induced <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell apoptosis through regulating the ERK1&#x2F;2 signaling pathway in a disc organ culture
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Articles

The response of nucleus pulposus cell senescence to static and dynamic compressions in a disc organ culture

Jianmin Shi, Lianglong Pang, Shouguo Jiao
Journal: Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20180064.
https://doi.org/10.1042/BSR20180064
Published: 09 March 2018
...Jianmin Shi; Lianglong Pang; Shouguo Jiao Mechanical stimuli obviously affect disc nucleus pulposus (NP) biology. Previous studies have indicated that static compression exhibits detrimental effects on disc biology compared with dynamic compression. To study disc NP cell senescence under static...
View article titled, The response of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence to static and dynamic compressions in a disc organ culture
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Articles

Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of nucleus pulposus cells in a disc perfusion culture

Haibo Zhou, Jianmin Shi, Chao Zhang, Pei Li
Journal: Bioscience Reports
Biosci Rep (2018) 38 (1): BSR20171551.
https://doi.org/10.1042/BSR20171551
Published: 08 February 2018
...Haibo Zhou; Jianmin Shi; Chao Zhang; Pei Li Mechanical compression often induces degenerative changes of disc nucleus pulposus (NP) tissue. It has been indicated that N-cadherin (N-CDH)-mediated signaling helps to preserve the NP cell phenotype. However, N-CDH expression and the resulting NP...
View article titled, Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells in a disc perfusion culture
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Articles

Resveratrol increases nucleus pulposus matrix synthesis through activating the PI3K/Akt signaling pathway under mechanical compression in a disc organ culture

Xiaorui Han, Xiaoming Leng, Man Zhao, Mei Wu, Amei Chen, Guoju Hong, Ping Sun
Journal: Bioscience Reports
Biosci Rep (2017) 37 (6): BSR20171319.
https://doi.org/10.1042/BSR20171319
Published: 23 November 2017
...Xiaorui Han; Xiaoming Leng; Man Zhao; Mei Wu; Amei Chen; Guoju Hong; Ping Sun Disc nucleus pulposus (NP) matrix homeostasis is important for normal disc function. Mechanical overloading seriously decreases matrix synthesis and increases matrix degradation. The present study aims to investigate...
View article titled, Resveratrol increases <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> matrix synthesis through activating the PI3K&#x2F;Akt signaling pathway under mechanical compression in a disc organ culture
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Articles

Role of p38–MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture

Lianglong Pang, Pei Li, Ruijie Zhang, Yuan Xu, Lei Song, Qiang Zhou
Journal: Bioscience Reports
Biosci Rep (2017) 37 (5): BSR20170718.
https://doi.org/10.1042/BSR20170718
Published: 11 October 2017
...Lianglong Pang; Pei Li; Ruijie Zhang; Yuan Xu; Lei Song; Qiang Zhou Nucleus pulposus (NP) cell senescence is a typical pathological feature within the degenerative intervertebral disc. As a potential inducing and aggregating factor of disc degeneration, mechanical overloading affects disc biology...
View article titled, Role of p38–MAPK pathway in the effects of high-magnitude compression on <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cell senescence in a disc perfusion culture
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Articles

Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of nucleus pulposus cells in a disc bioreactor culture

Pei Li, Ruijie Zhang, Liyuan Wang, Yibo Gan, Yuan Xu, Lei Song, Lei Luo, Chen Zhao, Chengmin Zhang, Bin Ouyang, Bing Tu, Qiang Zhou
Journal: Bioscience Reports
Biosci Rep (2017) 37 (2): BSR20160582.
https://doi.org/10.1042/BSR20160582
Published: 28 April 2017
...Pei Li; Ruijie Zhang; Liyuan Wang; Yibo Gan; Yuan Xu; Lei Song; Lei Luo; Chen Zhao; Chengmin Zhang; Bin Ouyang; Bing Tu; Qiang Zhou Long-term exposure to a mechanical load causes degenerative changes in the disc nucleus pulposus (NP) tissue. A previous study demonstrated that N-cadherin (N-CDH...
View article titled, Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of <span class="search-highlight">nucleus</span> <span class="search-highlight">pulposus</span> cells in a disc bioreactor culture
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