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Keywords: obesity
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Articles
Biosci Rep (2021) 41 (8): BSR20210979.
Published: 20 August 2021
... become a significant concern for public health. Obesity is highly prevalent worldwide and is considered a risk factor for impairing the adaptive immune system. Although diabetes, hypertension, cardiovascular disease (CVD), and renal failure are considered the risk factors for COVID-19, obesity is not yet...
Articles
Biosci Rep (2021) 41 (5): BSR20210029.
Published: 14 May 2021
...-recognised link between the ADAM17 substrate tumour necrosis factor α (TNF-α) and obesity, inflammation and diabetes. In addition, knocking out ADAM17 in mice leads to an extremely lean phenotype. Importantly, ADAM17-deficient mice exhibit one of the most pronounced examples of hypermetabolism in rodents...
Articles
Biosci Rep (2021) 41 (1): BSR20201707.
Published: 29 January 2021
...Venkatesh Gopalan; Jadegoud Yaligar; Navin Michael; Kavita Kaur; Rengaraj Anantharaj; Sanjay Kumar Verma; Suresh Anand Sadananthan; Giang Thi Thu Le; Jorming Goh; S. Sendhil Velan Investigations of long-term exercise interventions in humans to reverse obesity is expensive and is hampered by poor...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (9): BSR20192910.
Published: 21 September 2020
...Amal Ahmed Mohamed; Wafaa Gh. Shousha; Moushira Erfan Zaki; Hala T. El-Bassyouni; Hadeel El-Hanafi; Sara M. Abdo Background: Obesity is an alarming threat to health in Egypt. More than one in three Egyptians is obese, the highest rate in the world. We aimed to delineate the variability...
Articles
Biosci Rep (2020) 40 (6): BSR20194076.
Published: 09 June 2020
...Sunhye Shin; Asma S. El-Sabbagh; Brandon E. Lukas; Skylar J. Tanneberger; Yuwei Jiang Adipose tissue, the storage of excessive energy in the body, secretes various proteins called adipokines, which connect the body’s nutritional status to the regulation of energy balance. Obesity triggers...
Articles
Biosci Rep (2020) 40 (2): BSR20200131.
Published: 11 February 2020
.... Not all mutations show symptoms in the same tissues. For example, mitochondrial 1555A>G mutation mostly appears in deafness [ 4 ], mitochondrial 11778G>A mutation only appear in Leber’s hereditary optic neuropathy (LHON) [ 5 ] etc. Obesity is the only characteristic of the patient. Cerebrospinal...
Articles
Biosci Rep (2020) 40 (2): BSR20194502.
Published: 11 February 2020
...Josef Finsterer In a recent article Wang et al. reported about a 9-year-old Chinese male with obesity, insulin resistance, acanthosis nigricans, hyperuricemia, and non-alcoholic fatty liver disease (NALFD) being attributed to the variant m.5802A>G in tRNA(Cys) ( Bioscience Reports (2020) 40 (1...
Articles
Biosci Rep (2020) 40 (1): BSR20192153.
Published: 06 January 2020
...Jinling Wang; Ningning Zhao; Xiaoting Mao; Feilong Meng; Ke Huang; Guanping Dong; Yanchun Ji; JunFen Fu A Chinese family with matrilineally inherited obesity was assessed and its clinical, genetic, and molecular profiling was conducted. Obesity was observed in matrilineal relatives (3 out of 7...
Articles
Biosci Rep (2019) 39 (12): BSR20190498.
Published: 28 November 2019
...Jing Tao; Mayila Abudoukelimu; Xin Shen; Jun Liu; Feng-xia Wang; Jie Yuan; Pei-Pei Gu; Wei Zhu; Xiao-tian Zhang; Zhao Wang; Yi-tong Ma; Guo-qing Li Background: Obesity is a common heritable trait and a major risk factors of chronic and metabolic diseases. Insulin-induced gene 1 (INSIG1) is known...
Articles
Biosci Rep (2019) 39 (9): BSR20182042.
Published: 09 September 2019
...Rihua Zhang; Jing Bao Kan; Shan Lu; Pei Tong; Jie Yang; Ling Xi; Xiubing Liang; Dongming Su; Dong Li; Yun Liu The steadily increasing epidemic of obesity continues at alarming rates, is an important public health problem, and expression changes of S100A16 and 11 β-hydroxysteroid dehydrogenase type...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20181873.
Published: 14 December 2018
... Attribution License 4.0 (CC BY) . FGF21 high fat diet metabolic disorders obesity preconditioning Central obesity and insulin resistance are fundamental to the pathogenesis of the metabolic syndrome [ 1 , 2 ]. Increased consumption of high-calorie diets and decreased energy expenditure...
Articles
Biosci Rep (2018) 38 (4): BSR20180281.
Published: 06 July 2018
...Shabana; Saleem Ullah Shahid; Shahida Hasnain We aimed to identify the genetic causes of common forms of obesity in the Pakistani people and find out the mechanistic link by observing the relationship of genes and serum lipid traits. Four hundred and seventy-five subjects were genotyped for two...
Articles
Biosci Rep (2018) 38 (4): BSR20180553.
Published: 06 July 2018
...Yan Zhou; Qi Pan; Xiaoxia Wang; Lina Zhang; Fei Xiao; Lixin Guo The study aimed to explore the prevalence of human adenovirus-36 (HAdV-36) infection and the association of HAdV-36 with obesity in Chinese Han population. A qualitative determination using ELISA was performed to determine...
Articles
Biosci Rep (2018) 38 (2): BSR20171033.
Published: 05 March 2018
...-induced obesity (DIO). Twelve-week-old male C57Bl/6 mice received a control (C) or a high-fat diet (H). Half of them had free access to running wheels for 5 days/week for 10 weeks (CE) and HE, respectively). Hypothalamic expression of genes related to energy homeostasis, and leptin (Stat3 and p-Stat3...
Articles
Biosci Rep (2017) 37 (4): BSR20171089.
Published: 31 August 2017
... accumulation in skeletal muscles and adipose tissue is widely associated with the impairment of insulin signalling. While the angiogenic role of VEGF-A and its increased circulating concentrations in obesity have been widely confirmed, the data related to the metabolic role of VEGF-B are diverse. However...
Articles
Biosci Rep (2017) 37 (3): BSR20170286.
Published: 11 May 2017
...Jia Zheng; Sheng Zheng; Qianyun Feng; Qian Zhang; Xinhua Xiao Obesity is a growing public health problem, which has now been considered as a pandemic non-communicable disease. However, the efficacy of several approaches for weight loss is limited and variable. Thus, alternative anti-obesity...
Articles
Biosci Rep (2017) 37 (1): BSR20160184.
Published: 03 February 2017
...Sara L. Pulit; Tugce Karaderi; Cecilia M. Lindgren Obesity is a chronic condition associated with increased morbidity and mortality and is a risk factor for a number of other diseases including type 2 diabetes and cardiovascular disease. Obesity confers an enormous, costly burden on both...
Articles
Biosci Rep (2015) 35 (5): e00262.
Published: 30 October 2015
...Shaohai Xu; Peng Chen; Lei Sun BAT (brown adipose tissue) is specialized to burn fatty acids for heat generation and energy expenditure to defend against cold and obesity. Accumulating studies have demonstrated that manipulation of BAT activity through various strategies can regulate metabolic...
Articles
Biosci Rep (2015) 35 (3): e00200.
Published: 11 June 2015
...Brittany Beauchamp; A. Brianne Thrush; Jessica Quizi; Ghadi Antoun; Nathan McIntosh; Osama Y. Al-Dirbashi; Mary-Elizabeth Patti; Mary-Ellen Harper Intrauterine growth restriction (IUGR) is associated with an increased risk of developing obesity, insulin resistance and cardiovascular disease...
Includes: Supplementary data
Articles
Biosci Rep (2014) 34 (5): e00144.
Published: 22 October 2014
...Pawan Gulati; Edward Avezov; Marcella Ma; Robin Antrobus; Paul Lehner; Stephen O’Rahilly; Giles S. H. Yeo SNPs (single nucleotide polymorphisms) on a chromosome 16 locus encompassing FTO , as well as IRX3 , 5 , 6 , FTM and FTL are robustly associated with human obesity. FTO catalyses the Fe(II...
Articles
Biosci Rep (2014) 34 (5): e00141.
Published: 02 October 2014
... lipin lipolysis metabolism obesity Lipodystrophy is characterized by the selective loss of adipose tissue, with manifestation of clinically heterogeneous phenotypes. Since a key function of adipose tissue is the storage of excess energy in the form of lipids, extreme loss of fat...
Articles
Biosci Rep (2012) 32 (6): 619–629.
Published: 19 October 2012
...Chanjuan Hao; Xuejia Cheng; Hongfei Xia; Xu Ma The environmental obesogen hypothesis proposes that exposure to endocrine disruptors during developmental ‘window’ contributes to adipogenesis and the development of obesity. MEHP [mono-(2-ethylhexyl) phthalate], a metabolite of the widespread...
Articles
Biosci Rep (1987) 7 (11): 843–851.
Published: 01 November 1987
...Narinder Singh Shargill; Ibtisam Al-Baker; David A. York In an attempt to understand the hyper-responsiveness to glucocorticoids that is characteristic of genetically obese fa/fa rats, we have measured the levels of free corticosterone in serum from lean and obese rats as well as the number...