... viral protein is able to modulate viral gene expression, activate NF-κB signaling pathways, deregulate the cell cycle, disrupt apoptosis, and induce genomic instability. The summation of these processes results in cellular transformation and virus-mediated oncogenesis. Interestingly, HTLV-1 also encodes...

... 16 04 2020 27 04 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . microRNA oncogenesis prostate cancer...

...-coding RNA microRNA oncogenesis gene therapy Altered expression of miRNAs under hypoxia may induce a pathological process via modulating the expression of their downstream genes [ 18 ]. Hypoxia-induced up-regulation of miR-301a/b increased cell autophagy and viability of prostate cancer (PCa...

... Immunohistochemistry oncogenesis Matrigel (Corning) was thawed overnight in a 4°C refrigerator and subsequently plated 50 µl in a 96-well plate. Cell suspension was prepared using 0.5 × 10 4 cells/ml in conditioned medium, obtained from HEK293T cells transfected with FRG1 expression vector and empty vector...

... of the functional implication of the RANK/RANKL system in cancer development, and to underline the most recent clinical studies. microenvironment oncogenesis RANK RANKL In a physiological context, a healthy tissue microenvironment provides an adapted 3D microarchitecture with essential intercellular...