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Keywords: osteoarthritis
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Articles
Biosci Rep (2020) 40 (12): BSR20193823.
Published: 16 December 2020
...Bin Zuo; JunFeng Zhu; Fei Xiao; ChengLong Wang; Yun Shen; XiaoDong Chen Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are two major types of joint diseases. The present study aimed to identify hub genes involved in the pathogenesis and further explore the potential treatment targets...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20200926.
Published: 13 November 2020
...Senbo An; Jingyi Li; Wenqing Xie; Ni Yin; Yusheng Li; Yihe Hu Osteoarthritis (OA), the most common degenerative joint disease, is characterized by the cardinal symptoms of chronic pain and restricted joint activity. The complicated pathological changes associated with OA and unclear mechanistic...
Articles
Biosci Rep (2020) 40 (11): BSR20201601.
Published: 03 November 2020
...Qingpu Zhang; Xiaomiao Qiao; Wenwei Xia The dysregulated circular RNAs (circRNAs) are relevant to the development of osteoarthritis (OA). The circRNA serpin family E member 2 (circSERPINE2) is dysregulated in OA, while the role and mechanism of circSERPINE2 in OA are largely unknown. The aim of our...
Articles
Biosci Rep (2020) 40 (9): BSR-20160578_EOC.
Published: 28 September 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Chondrocyte MicroRNA-146a NF-κB signaling pathway Osteoarthritis...
Articles
Biosci Rep (2020) 40 (9): BSR20192095.
Published: 16 September 2020
...Shijie Gao; Liang Liu; Shibo Zhu; Dawei Wang; Qiang Wu; Guangzhi Ning; Shiqing Feng Recent studies have demonstrated that microRNAs (miRNAs) are involved in many pathological conditions including osteoarthritis (OA). In the present study, we aimed to investigate the role of miR-197 in OA and the...
Articles
Biosci Rep (2020) 40 (9): BSR20194207.
Published: 04 September 2020
...Chen-Chen Ji; Bo Liu; Yi-Jie Shao; Ting Liang; Hua-Ye Jiang; Guang-Dong Chen; Zong-Ping Luo Objectives: In the treatment of osteoarthritis (OA), tramadol, a common weak opioid, has become popular due to its effectiveness in inhibition of pain. In the present study, we aimed to explore the effect of...
Articles
Biosci Rep (2020) 40 (6): BSR20191908.
Published: 22 June 2020
...Yinwei Bai; Kun Chen; Jianfeng Zhan; Mingxin Wu Background/Aims: MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms. Methods: The...
Articles
Biosci Rep (2020) 40 (6): BSR20200466.
Published: 15 June 2020
...Jinyu Wang; Liming Fang; Lili Ye; Shiliang Ma; Haoran Huang; Xiaoquan Lan; Jianlin Ma Purpose: To explore the regulatory mechanism of miR-137 and transcription factor 4 (TCF4) in the progression of osteoarthritis (OA). Patients and Methods: The expressions of miR-137 and TCF4 were detected in OA...
Articles
Biosci Rep (2020) 40 (5): BSR20200417.
Published: 28 May 2020
...Yu Zhao; Ding Ma; Bingchen Dong; Ming Li This research aimed to explore the role of period circadian clock 2 (Per2) in the evolution of osteoarthritis (OA) and the relevant mechanisms. Per2 messenger RNA (mRNA) and protein levels were markedly reduced in NHAC-kn cells treated with 5 µg/ml...
Articles
Biosci Rep (2020) 40 (3): BSR20192620.
Published: 25 March 2020
...Shichang Yan; Huimin Ding; Junyang Peng; Xinqiang Wang; Chenglong Pang; Juncheng Wei; Jianjun Wei; Hui Chen Recently, protease-activated receptor 2 (PAR2) has been proved to be involved in the inflammatory response including osteoarthritis (OA). In the present study, we found that PAR2 antagonist...
Articles
Biosci Rep (2020) 40 (3): BSR20192723.
Published: 13 March 2020
...Yongbo An; Guang Wan; Jingang Tao; Mingxing Cui; Qinglan Zhou; Wengen Hou Osteoarthritis (OA) is a chronic and prevalent degenerative musculoskeletal disorder, which is characterized by articular cartilage degradation and joint inflammation. MicroRNA-203a (miR-203a) has been shown to be involved in...
Articles
Biosci Rep (2020) 40 (1): BSR20191017.
Published: 10 January 2020
...Wanli Ma; Xiaohe Wang; Chunhui Wang; Mingzhi Gong; Peng Ren Osteoarthritis is mainly caused by a degenerative joint disorder, which is characterized by the gradual degradation of articular cartilage and synovial inflammation. The chondrocyte, the unique resident cell type of articular cartilage, is...
Articles
Biosci Rep (2019) 39 (10): BSR20191255.
Published: 18 October 2019
...Fang Li; Jianhua Yao; Qingqing Hao; Zheping Duan Objectives: The aim of the present study was to determine the effects of miRNA-103 on chondrocyte apoptosis and molecular mechanisms in osteoarthritis (OA) progression. Methods: The cell proliferation, apoptosis, and recovery ability were measured by...
Articles
Biosci Rep (2019) 39 (9): BSR20191523.
Published: 06 September 2019
...Jinlai Lei; Yahui Fu; Yan Zhuang; Kun Zhang; Daigang Lu Long non-coding RNA (LncRNA) small nucleolar RNA host gene 1 (SNHG1) has been reported in the occurrence and development of several diseases, but its biological role and mechanism in osteoarthritis (OA) remain to be illuminated. In the present...
Articles
Biosci Rep (2019) 39 (7): BSR20191374.
Published: 19 July 2019
...Min Tu; Yao Yao; Feng Hua Qiao; Li Wang Osteoarthritis (OA) is the most common form of arthritis, and connective tissue growth factor (CTGF) is found to be up-regulated in adjacent areas of cartilage surface damage. CTGF is present in osteophytes of late stage OA. In the present study, we have...
Articles
Biosci Rep (2019) 39 (6): BSR20190404.
Published: 07 June 2019
...Mingwei Jiang; Jie Liu; Tao Luo; Qiu Chen; Ming Lu; Deqiang Meng LncRNA PACER is a chondrocyte inflammation-associated long non-coding RNA (lncRNA), and chondrocyte inflammation is involved in osteoarthritis (OA). We observed that plasma PACER was down-regulated, while plasma HOTAIR was up...
Articles
Biosci Rep (2019) 39 (5): BSR20182454.
Published: 14 May 2019
...Tao Huang; Jian Wang; Yuan Zhou; Yi Zhao; Donghua Hang; Yun Cao Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were...
Articles
Biosci Rep (2019) 39 (4): BSR20181960.
Published: 12 April 2019
...Lei Peng; Jie Bin; Yang-chao Ou; Li-xin Zhu; Ji-ping Lu Background. A relationship between matrix metalloproteinase-1 (MMP-1)-1607 (rs1799750) gene polymorphism and osteoarthritis (OA) susceptibility was reported in the Bioscience Reports journal; however, these results were inconsistent. To...
Articles
Biosci Rep (2019) 39 (4): BSR20182025.
Published: 09 April 2019
...Zhi Zhao; Xiu-Song Dai; Zhi-Yan Wang; Zheng-Qi Bao; Jian-Zhong Guan Objective: Inflammation is closely implicated in the process of osteoarthritis (OA) and affects disease progression and pain. Herein, the present study explored the effect of microRNA-26a (miR-26a) on the synovial inflammation and...
Articles
Biosci Rep (2019) 39 (2): BSR20181473.
Published: 15 February 2019
...Li Tan; Raghunatha R. Yammani Obesity, a major risk factor for the development of osteoarthritis (OA), is associated with increased circulating levels of free fatty acids (FFA). However, the role of these FFAs in OA pathophysiology is not clearly understood. In the present study, we found that...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (2): BSR20181346.
Published: 01 February 2019
...Gang Sun; Cheng-Lei Ba; Ren Gao; Wenqing Liu; Qiang Ji Objective: To identify the association between the interleukin (IL) 6 ( IL-6 ) rs1800795 (-174 G>C), IL-8 rs4073 (-251T>A), and matrix metalloproteinase-13 ( MMP-13 ) rs2252070 (-77G>A) gene polymorphisms and knee osteoarthritis (KOA...
Articles
Biosci Rep (2019) 39 (1): BSR20182228.
Published: 25 January 2019
...Wenpeng Hui; Zhong Cao; Xiao Wang; Junfeng Zhu Several studies have explored the association between matrix Gla protein (MGP) gene polymorphism and knee osteoarthritis (OA) risk; however, they obtained conflicting findings. The present study aims to explore the association of MGP gene polymorphism...
Articles
Biosci Rep (2018) 38 (6): BSR20181228.
Published: 14 December 2018
...Lei Zhang; Pin Zhang; Xiangyi Sun; Liwu Zhou; Jianning Zhao Osteoarthritis (OA) is one of the most common chronic joint disease. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in a variety of diseases including OA. However, the underlying mechanism of lncRNA...
Articles
Biosci Rep (2018) 38 (6): BSR20181619.
Published: 30 November 2018
... meta analysis osteoarthritis single nucleotide polymorphisms Musculoskeletal degenerative diseases are a diverse group of pathological conditions affecting bone, cartilage, joint and other connective tissues. They are typically characterized by severe chronic pain, stiffness, activity...
Articles
Biosci Rep (2018) 38 (5): BSR20180542.
Published: 31 October 2018
...Hui-Zi Li; Zhong Lin; Xiang-He Xu; Nan Lin; Hua-Ding Lu Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (5): BSR20180576.
Published: 28 September 2018
...Yangxue Zhao; Jiang Zhao; Xufeng Guo; Jiang She; Yongjun Liu Osteoarthritis (OA), a common form of degenerative joint disease, is typified by inflammatory response and the loss of cartilage matrix. Long non-coding RNAs (lncRNAs) are emerging as a new player in gene regulation and exert critical...
Articles
Biosci Rep (2018) 38 (4): BSR20171691.
Published: 03 July 2018
...Guowang Zhang; Jiaqing Cao; Erzhu Yang; Bo Liang; Jianing Ding; Jiaming Liang; Jianguang Xu Reduced autophagy has been implied in chondrocyte death and osteoarthritis. Curcumin (Cur) owns therapeutic effect against osteoarthritis (OA) and enhances autophagy in various tumor cells. Whether the...
Articles
Biosci Rep (2018) 38 (3): BSR20180380.
Published: 15 May 2018
...Hao-Yu Yang; Wen-Hao Hu; Tao Jiang; Hui Zhao A growing body of evidence suggested that smad family member 3 gene rs12901499 polymorphism was associated with the risk of osteoarthritis. However, the results of previous studies were conflicting. In the present study, we assessed whether smad family...
Articles
Biosci Rep (2017) 37 (4): BSR20170180.
Published: 12 July 2017
...) Biosci. Rep. 37 , BSR20160578], which explores microRNA-146a and how it may play an indirect yet vital role in the proliferation of osteoarthritis (OA) chondrocytes. The data presented by the authors could have important implications for future OA therapies. Overall, this study provides compelling data...
Articles
Biosci Rep (2017) 37 (2): BSR20160578.
Published: 28 April 2017
...Jun-Hua Zhong; Jing Li; Cui-Fang Liu; Ning Liu; Rui-Xiang Bian; Shou-Mei Zhao; Shu-Yi Yan; Yong-Bing Zhang The present study aims to investigate the effects of miR-146a on the proliferation and apoptosis of human osteoarthritis (OA) chondrocytes by targeting tumour necrosis factor receptor...
Articles
Biosci Rep (2017) 37 (2): BSR20160588.
Published: 28 April 2017
...Jiye He; Jiahong Zhang; Dongliang Wang Osteoarthritis (OA) is the most common type of joint disease, leading to a major cause of pain and disability. OA is characterized by the continuous degradation of articular cartilage, mainly resulting in an imbalance between synthesis and degradation of...
Articles
Biosci Rep (2016) 36 (3): e00332.
Published: 06 May 2016
...Meng Wei; Qingyun Xie; Jun Zhu; Tao Wang; Fan Zhang; Yue Cheng; Dongyang Guo; Ying Wang; Liweng Mo; Shuai Wang CCL2-mediated macrophage infiltration in articular tissues plays a pivotal role in the development of the osteoarthritis (OA). miRNAs regulate the onset and progression of diseases via...
Articles
Biosci Rep (2015) 35 (3): e00204.
Published: 11 June 2015
...Qingyun Xie; Meng Wei; Xia Kang; Da Liu; Yi Quan; Xianming Pan; Xiling Liu; Dongfa Liao; Jinbiao Liu; Bo Zhang Obesity is causally linked to osteoarthritis (OA), with the mechanism being not fully elucidated. miRNAs (miRs) are pivotal regulators of various diseases in multiple tissues, including...