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Articles

Transcriptional profiling reveals the role of Candida albicans Rap1 in oxidative stress response

Wen-Han Wang, Hsuan-Yu Chen, Sheng-Yuan Chen, Chung-Yu Lan

Biosci Rep (2024) 44 (12): BSR20240689.

https://doi.org/10.1042/BSR20240689

Published: 12 December 2024

... that Rap1 is also involved in cell wall integrity, biofilm formation, and virulence in C. albicans . In this work, using RNA-seq analysis and other approaches, the role of C. albicans Rap1 in oxidative stress response was further revealed. The RAP1 -deletion mutant exhibited greater resistance...

View articletitled, Transcriptional profiling reveals the role of Candida albicans Rap1 in oxidative stress response

Includes: Supplementary data

Articles

Simulated ischaemia/reperfusion impairs trophoblast function through divergent oxidative stress- and MMP-9-dependent mechanisms

Aaron Barron, Jetro J. Tuulari, Linnea Karlsson, Hasse Karlsson, Gerard W. O'Keeffe, Cathal M. McCarthy

Biosci Rep (2024) 44 (11): BSR20240763.

https://doi.org/10.1042/BSR20240763

Published: 21 November 2024

...Aaron Barron; Jetro J. Tuulari; Linnea Karlsson; Hasse Karlsson; Gerard W. O'Keeffe; Cathal M. McCarthy Early-onset pre-eclampsia is believed to arise from defective placentation in the first trimester, leading to placental ischaemia/reperfusion (I/R) and oxidative stress. However, our current...

View articletitled, Simulated ischaemia/reperfusion impairs trophoblast function through divergent oxidative stress- and MMP-9-dependent mechanisms

Articles

Neuroprotective properties of zinc oxide nanoparticles: therapeutic implications for Parkinson's disease

Kim San Tang, Wesley Zhi Chung See, Rakesh Naidu

Biosci Rep (2024) 44 (11): BSR20241102.

https://doi.org/10.1042/BSR20241102

Published: 06 November 2024

... pathology, as they can mitigate oxidative stress, improve stability and delivery of neuroprotective agents, and modulate inflammatory responses. Furthermore, ZnO-NPs also exhibit multifaceted neuroprotective properties, holding promise as a potential breakthrough in PD management [ 16 ]. ZnO-NPs, owing...

View articletitled, Neuroprotective properties of zinc oxide nanoparticles: therapeutic implications for Parkinson's disease

Articles

Protective effect of ( E )-(2,4-dihydroxy)-α-aminocinnamic acid, a hydroxy cinnamic acid derivative, in an ulcerative colitis model induced by TNBS

Astrid Mayleth Rivera Antonio, Itzia Irene Padilla Martínez, Yazmín Karina Márquez-Flores, Alan Hipólito Juárez Solano, Mónica A. Torres Ramos, Martha Cecilia Rosales Hernández

Biosci Rep (2024) 44 (10): BSR20240797.

https://doi.org/10.1042/BSR20240797

Published: 04 October 2024

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . hydroxycinnamic acids inflammatory bowel disease myeloperoxidase oxidative stress Correspondence: Martha Cecilia Rosales Hernández ( [email protected] ) Consejo Nacional de Ciencia y...

View articletitled, Protective effect of ( E )-(2,4-dihydroxy)-α-aminocinnamic acid, a hydroxy cinnamic acid derivative, in an ulcerative colitis model induced by TNBS

Includes: Supplementary data

Articles

Retraction: Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro

Biosci Rep (2024) 44 (8): BSR-2019-1711_RET.

https://doi.org/10.1042/BSR-2019-1711_RET

Published: 22 August 2024

.... intervertebral disc nucleus pulposus osmolarity oxidative stress senescence © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Following...

View articletitled, Retraction: Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro

Articles

Expression of Concern: Madecassoside protects retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis through the activation of Nrf2/HO-1 pathway

Biosci Rep (2024) 44 (6): BSR-2019-4347_EOC.

https://doi.org/10.1042/BSR-2019-4347_EOC

Published: 21 June 2024

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Age‐related macular degeneration (AMD) madecassoside (MADE) oxidative...

View articletitled, Expression of Concern: Madecassoside protects retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis through the activation of Nrf2/HO-1 pathway

Articles

miRNA-142-3p aggravates hydrogen peroxide-induced human umbilical vein endothelial cell premature senescence by targeting SIRT1

Pengfei Tong, Jingke Zhang, Shuang Liu, Jiyang An, Gehan Jing, Laifeng Ma, Ruihua Wang, Zhengfeng Wang

Biosci Rep (2024) 44 (5): BSR20231511.

https://doi.org/10.1042/BSR20231511

Published: 15 May 2024

... senescence caused by exogenous stress [ 10 ]. Exogenous stress conditions mainly include chemoradiotherapy, peroxide, metabolic wastes, telomere damage (caused by continuous cell proliferation), etc [ 10 , 11 ]. Oxidative stress-induced premature senescence is a widely used in vitro model of cell senescence...

View articletitled, miRNA-142-3p aggravates hydrogen peroxide-induced human umbilical vein endothelial cell premature senescence by targeting SIRT1

Includes: Supplementary data

Articles

Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

Barakat M. ALRashdi, Roaya A. Mohamed, Amal H. Mohamed, Feryal A. Samoul, Mazen I. Mohamed, Mohsen M. Moussa, Saad M. Alrashidi, Bassel Dawod, Ola A. Habotta, Ahmed E. Abdel Moneim, Shimaa S. Ramadan

Biosci Rep (2023) 43 (11): BSR20231130.

https://doi.org/10.1042/BSR20231130

Published: 10 November 2023

... developed severe renal dysfunction. Thus, effective therapeutic strategies are urgently needed to combat or prevent CDDP-induced renal injury. cisplatin inflammation nephrotoxicity oxidative stress selenium nanoparticles turmeric extract The relative kidney weight was calculated according...

View articletitled, Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

Articles

Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma

Mohit Arora, Sarita Kumari, Lokesh Kadian, Geethadevi Anupa, Jay Singh, Anurag Kumar, Deepika Verma, Raja Pramanik, Sunil Kumar, Rajni Yadav, Anita Chopra, Shyam S. Chauhan

Biosci Rep (2023) 43 (9): BSR20222472.

https://doi.org/10.1042/BSR20222472

Published: 06 September 2023

..., increased apoptosis, and inhibited migration of ESCC cells. Additionally, DPP3 knockdown leads to down-regulation of the NRF2 pathway proteins, such as NRF2, G6PD, and NQO1 along with increased sensitivity toward oxidative stress-induced cell death and chemotherapy. Conclusively, these results demonstrate...

View articletitled, Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma

Includes: Supplementary data

Articles

Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia

Louise C. Kenny, on behalf of the SCOPE Consortium, Leslie W. Brown, Paloma Ortea, Robin Tuytten, Douglas B. Kell

Biosci Rep (2023) 43 (7): BSR20230160.

https://doi.org/10.1042/BSR20230160

Published: 06 July 2023

... agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. Ergothioneine Metabolomics Oxidative stress Preeclampsia Figure 3 Lack of relationship between ergothioneine level and BMI. Data have been jiggered in the x -axis direction for clarity...

View articletitled, Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia

Includes: Supplementary data

Articles

Biochemical and histopathological effects of copper oxide nanoparticles exposure on the bivalve Chambardia rubens (Lamarck, 1819)

Mostafa Morad, Taha F. Hassanein, Manal F. El-khadragy, Alaa Fehaid, Ola A. Habotta, Ahmed Abdel Moneim

Biosci Rep (2023) 43 (5): BSR20222308.

https://doi.org/10.1042/BSR20222308

Published: 18 May 2023

... with 100 and 1000 µg Cu L −1 of copper oxide nanoparticles (CuONPs) or ionic copper (Cu 2+ ) for 3, 7, and 14 days. The Cu accumulation and markers of oxidative stress in the digestive glands and gills were evaluated. The results show that the digestive gland collected higher levels of the two forms...

View articletitled, Biochemical and histopathological effects of copper oxide nanoparticles exposure on the bivalve Chambardia rubens (Lamarck, 1819)

Articles

Role of Keap1-Nrf2/ARE signal transduction pathway in protection of dexmedetomidine preconditioning against myocardial ischemia/reperfusion injury

Hui-xian Li, Tai-hang Wang, Lin-xin Wu, Fu-shan Xue, Guo-hua Zhang, Tao Yan

Biosci Rep (2022) 42 (9): BSR20221306.

https://doi.org/10.1042/BSR20221306

Published: 02 September 2022

..., and the infarct size (IS) was assessed by Evan’s blue and 2,3,5-triphenyltetrazolium chloride (TTC) staining. Oxidative stress was assessed through Western blotting for expression of Keap1-Nrf2/ARE pathway members and oxidative stress markers. Results: Cardioprotection of DEX, tBHQ, and tBHQ+DEX preconditioning...

View articletitled, Role of Keap1-Nrf2/ARE signal transduction pathway in protection of dexmedetomidine preconditioning against myocardial ischemia/reperfusion injury

Articles

Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD + -Sirt3 pathway

Tao Wang, Fei Zhang, Wuxun Peng, Lei Wang, Jian Zhang, Wentao Dong, Xiaobin Tian, Chuan Ye, Yanlin Li, Yuekun Gong

Biosci Rep (2022) 42 (1): BSR20211005.

https://doi.org/10.1042/BSR20211005

Published: 14 January 2022

...Tao Wang; Fei Zhang; Wuxun Peng; Lei Wang; Jian Zhang; Wentao Dong; Xiaobin Tian; Chuan Ye; Yanlin Li; Yuekun Gong Oxidative stress damage is a common problem in bone marrow mesenchymal stem cell (BMSC) transplantation. Under stress conditions, the mitochondrial function of BMSCs is disrupted...

View articletitled, Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD + -Sirt3 pathway

Includes: Supplementary data

Articles

In vivo therapeutic exploring for Mori folium extract against type 2 diabetes mellitus in rats

Kaibo Lyu, Wei Yue, Junhua Ran, Yunjuan Liu, Xueliang Zhu

Biosci Rep (2021) 41 (12): BSR20210977.

https://doi.org/10.1042/BSR20210977

Published: 08 December 2021

... of high sugar and high-fat diet (HSFD) and streptozotocin (STZ). The T2DM rats were administrated with low (2 g.kg −1 ) and high (5 g.kg −1 ) doses of MFAE for 60 consecutive days. The biochemical indices of glucose metabolism disorders, insulin resistance and oxidative stress were observed. The results...

View articletitled, In vivo therapeutic exploring for Mori folium extract against type 2 diabetes mellitus in rats

Articles

Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects

Xinhui Liu, Ruyu Deng, Xian Wei, Yuzhi Wang, Jiali Weng, Yunlan Lao, Jiandong Lu, Guoliang Xiong, Shunmin Li

Biosci Rep (2021) 41 (10): BSR20211598.

https://doi.org/10.1042/BSR20211598

Published: 22 October 2021

... lesions and ameliorate renal fibrosis in CKD rats. Administration of PE and JPYSF enhanced sirtuin 3 (SIRT3) expression, inhibited mitochondrial fission, promoted mitochondrial fusion, and suppressed oxidative stress in the kidney of CKD rats. In conclusion, combined use of PE and JPYSF protected against...

View articletitled, Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects

Includes: Supplementary data

Articles

Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice

Xudong Liu, Yuchao Zhang, Yaolin Ren, Jinquan Li

Biosci Rep (2021) 41 (9): BSR20210398.

https://doi.org/10.1042/BSR20210398

Published: 22 September 2021

...% fluorescein isothiocyante (FITC) applied to the skin, followed by an ovalbumin (OVA) airway challenge. In addition, by examining serum immunoglobulin (Ig) concentrations, airway cytokines, the levels of oxidative stress markers, histopathological changes in lung tissue and airway hyperresponsiveness (AHR), we...

View articletitled, Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice

Includes: Supplementary data

Articles

MicroRNAs targeting VEGF are related to vascular dysfunction in preeclampsia

Isabel Witvrouwen, Dominique Mannaerts, Jessica Ratajczak, Evi Boeren, Ellen Faes, Amaryllis H. Van Craenenbroeck, Yves Jacquemyn, Emeline M. Van Craenenbroeck

Biosci Rep (2021) 41 (8): BSR20210874.

https://doi.org/10.1042/BSR20210874

Published: 12 August 2021

... pregnancies (HPs), and their relation with vascular function, oxidative stress (OS) and systemic inflammation. In this case–control study, 24 women with early PE (<34 weeks) were compared with 30 women with HP. Circulating microRNA levels (RT-qPCR), OS and systemic inflammation were assessed in plasma...

View articletitled, MicroRNAs targeting VEGF are related to vascular dysfunction in preeclampsia

Articles

Correction: Antioxidative and anti-photoaging activities of neferine upon UV-A irradiation in human dermal fibroblasts

Biosci Rep (2021) 41 (7): BSR-2018-1414_COR.

https://doi.org/10.1042/BSR-2018-1414_COR

Published: 01 July 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Antioxidant Fibroblasts Neferine Oxidative stress Ultraviolet...

View articletitled, Correction: Antioxidative and anti-photoaging activities of neferine upon UV-A irradiation in human dermal fibroblasts

Articles

Endostatin attenuates heart failure via inhibiting reactive oxygen species in myocardial infarction rats

Xuguang Xu, Tingbo Jiang, Yong Li, Liusha Kong

Biosci Rep (2021) 41 (7): BSR20200787.

https://doi.org/10.1042/BSR20200787

Published: 29 June 2021

... improved cardiac dysfunction and hemodynamics, and attenuated cardiac fibrosis and hypertrophy via inhibiting oxidative stress in MI-induced HF rats. Correspondence: Tingbo Jiang ( [email protected] ) 20 03 2020 30 06 2020 02 07 2020 20 07 2020 © 2020 The Author(s). 2020...

View articletitled, Endostatin attenuates heart failure via inhibiting reactive oxygen species in myocardial infarction rats

Articles

Correction: Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity

Biosci Rep (2021) 41 (4): BSR-20180861_COR.

https://doi.org/10.1042/BSR-20180861_COR

Published: 27 April 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis brain cadmium Fragaria ananassa oxidative stress...

View articletitled, Correction: Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity

Articles

Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress

Wei Gao, Yongxun Jin, Jindong Hao, Siyi Huang, Dongxu Wang, Fushi Quan, Mingjun Zhang, Jiabao Zhang, Wenzhi Ren, Xianfeng Yu

Biosci Rep (2021) 41 (4): BSR20203091.

https://doi.org/10.1042/BSR20203091

Published: 22 April 2021

... indicate that exposure to 20 µM HU caused significant oxidative stress and apoptosis of MII oocytes during maturation, which affected their developmental ability. These results provide valuable information for safety assessments of HU. All chemicals and reagents, except those specifically noted, were...

View articletitled, Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress

Includes: Supplementary data

Articles

Expression of Concern: Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity

Biosci Rep (2021) 41 (3): BSR-20180861_EOC.

https://doi.org/10.1042/BSR-20180861_EOC

Published: 26 March 2021

... apoptosis brain cadmium Fragaria ananassa oxidative stress The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. © 2021...

View articletitled, Expression of Concern: Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity

Articles

Expression of Concern: Antioxidative and anti-photoaging activities of neferine upon UVA irradiation in human dermal fibroblasts

Biosci Rep (2021) 41 (2): BSR-20181414_EOC.

https://doi.org/10.1042/BSR-20181414_EOC

Published: 17 February 2021

View articletitled, Expression of Concern: Antioxidative and anti-photoaging activities of neferine upon UVA irradiation in human dermal fibroblasts

Articles

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation

Fei Yan, Qi Zhao, Huanpeng Gao, Xiaomei Wang, Ke Xu, Yishu Wang, Fuguo Han, Qingfei Liu, Yun Shi

Biosci Rep (2021) 41 (2): BSR20203955.

https://doi.org/10.1042/BSR20203955

Published: 12 February 2021

... enrichment analysis were carried out by the Database for Annotation, Visualization and Integrated Discovery (DAVID) database. Furthermore, KGN cells were performed to validate the predicted results in oxidative stress (OS) model, and antioxidant effect was examined. Results: A total of 70 potential common...

View articletitled, Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation

Articles

Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K/Akt/mTOR signaling pathway

Zhenling Ma, Wenwen Zhang, Yaru Wu, Menghao Zhang, Lei Wang, Yihan Wang, Yi Wang, Wei Liu

Biosci Rep (2021) 41 (1): BSR20203219.

https://doi.org/10.1042/BSR20203219

Published: 29 January 2021

...Zhenling Ma; Wenwen Zhang; Yaru Wu; Menghao Zhang; Lei Wang; Yihan Wang; Yi Wang; Wei Liu The excessive and inappropriate production of reactive oxygen species (ROS) can cause oxidative stress and is implicated in the pathogenesis of lung cancer. Cyclophilin A (CypA), a member of the immunophilin...

View articletitled, Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K/Akt/mTOR signaling pathway

Articles

UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression

Pan Yuan, Li Zhou, Xiaona Zhang, Lan Yao, Jun Ning, Xiao Han, Caifeng Ming, Yunhe Zhao, Liqun Zhang

Biosci Rep (2020) 40 (10): BSR20201308.

https://doi.org/10.1042/BSR20201308

Published: 30 October 2020

..., UCH-L1 inhibitor LDN-57444 suppressed mouse oocyte maturation by improving oxidative stress, attenuating mitochondrial function, curbing spindle body formation and down-regulating extracellular signal-related kinases (ERK1/2) expression, providing a deep insight into the cellular and molecular basis...

View articletitled, UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression

Articles

Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

Christopher P. Hedges, Toan Pham, Bhoopika Shetty, Stewart W.C. Masson, Anthony J.R. Hickey, Peter R. Shepherd, Troy L. Merry

Biosci Rep (2020) 40 (10): BSR20201128.

https://doi.org/10.1042/BSR20201128

Published: 16 October 2020

... to determine the effect of prolonged oral treatment with the selective PI3K p110α inhibitor BYL-719 on liver and skeletal muscle mitochondrial function and content, and oxidative stress, in adult mice. We report here that despite acutely elevating hepatic mitochondrial biogenesis-related genes in the liver...

View articletitled, Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

Includes: Supplementary data

Articles

Madecassoside protects retinal pigment epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis through the activation of Nrf2/HO-1 pathway

Jinzi Zhou, Fenghua Chen, Aimin Yan, Xiaobo Xia

Biosci Rep (2020) 40 (10): BSR20194347.

https://doi.org/10.1042/BSR20194347

Published: 14 October 2020

...Jinzi Zhou; Fenghua Chen; Aimin Yan; Xiaobo Xia Age-related macular degeneration (AMD) is a progressive and degenerative ocular disease associated with oxidative stress. Madecassoside (MADE) is a major bioactive triterpenoid saponin that possesses antioxidative activity. However, the role of MADE...

View articletitled, Madecassoside protects retinal pigment epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis through the activation of Nrf2/HO-1 pathway

Articles

Expression of Concern: The molecular and biochemical insight view of grape seed proanthocyanidins in ameliorating Cadmium-induced Testes-toxicity in rat model: Implication of PI3K/Akt/Nrf-2signaling

Biosci Rep (2020) 40 (8): BSR-20180515_EOC.

https://doi.org/10.1042/BSR-20180515_EOC

Published: 04 August 2020

... The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. cadmium oxidative stress antioxidant grape seed proanthocyanidins Nrf2...

View articletitled, Expression of Concern: The molecular and biochemical insight view of grape seed proanthocyanidins in ameliorating Cadmium-induced Testes-toxicity in rat model: Implication of PI3K/Akt/Nrf-2signaling

Articles

Concentrated growth factor inhibits UVA-induced photoaging in human dermal fibroblasts via the MAPK/AP-1 pathway

Meng Zhang, Tai Zhang, Yanan Tang, Guiyun Ren, Yanning Zhang, Xiangyu Ren

Biosci Rep (2020) 40 (7): BSR20193566.

https://doi.org/10.1042/BSR20193566

Published: 17 July 2020

...Meng Zhang; Tai Zhang; Yanan Tang; Guiyun Ren; Yanning Zhang; Xiangyu Ren Ultraviolet (UV) radiation-induced photoaging is one of the contributors to skin aging. UV light triggers oxidative stress, producing a large number of matrix metalloproteinases (MMPs) and degrading the extracellular matrix...

View articletitled, Concentrated growth factor inhibits UVA-induced photoaging in human dermal fibroblasts via the MAPK/AP-1 pathway

Articles

Protective effect of anisodamine hydrobromide on lipopolysaccharide-induced acute kidney injury

Feng Wan, Xiaoqiang Du, Huan Liu, Xueling He, Ye Zeng

Biosci Rep (2020) 40 (7): BSR20201812.

https://doi.org/10.1042/BSR20201812

Published: 30 June 2020

.... Hemodynamic parameters including blood pressure and heart rate were measured. The histopathologic evaluation of kidney tissues was performed. Lactate, creatine kinase, inflammatory cytokines and oxidative stress indicators were determined. Using Seahorse analysis, the metabolic analysis of mitochondrial...

View articletitled, Protective effect of anisodamine hydrobromide on lipopolysaccharide-induced acute kidney injury

Articles

Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway

Aimin Liu, Wei Zhao, Buxin Zhang, Yuanhui Tu, Qingxing Wang, Jing Li

Biosci Rep (2020) 40 (6): BSR20200471.

https://doi.org/10.1042/BSR20200471

Published: 17 June 2020

...) and MAPK (JNK, ERK, and p38) signaling pathways. Similar alterations for oxidative stress and inflammation parameters were also detected in TNF-α-treated HaCaT cells. In addition, cimifugin-induced down-regulation of ICAM-1 were observed in TNF-α-treated cells. Altogether, our findings suggest...

View articletitled, Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway

Articles

Serum levels of superoxide dismutases in patients with benign paroxysmal positional vertigo

Jing Li, Rui Wu, Bin Xia, Xinhua Wang, Mengzhou Xue

Biosci Rep (2020) 40 (5): BSR20193917.

https://doi.org/10.1042/BSR20193917

Published: 20 May 2020

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Benign paroxysmal positional vertigo oxidative stress recurrence superoxide dismutases Oxidative stress as a concept in redox biology and medicine had been formulated in 1985; at the beginning...

View articletitled, Serum levels of superoxide dismutases in patients with benign paroxysmal positional vertigo

Articles

Catalpol protects rat ovarian granulosa cells against oxidative stress and apoptosis through modulating the PI3K/Akt/mTOR signaling pathway

Jin Yan, Disi Deng, Yeke Wu, Keming Wu, Jie Qu, Fei Li

Biosci Rep (2020) 40 (4): BSR20194032.

https://doi.org/10.1042/BSR20194032

Published: 17 April 2020

...Jin Yan; Disi Deng; Yeke Wu; Keming Wu; Jie Qu; Fei Li Disrupted follicular development may result in increased follicular atresia, which is a crucial mechanism of various ovarian pathologies. It has been demonstrated that oxidative stress is associated with disrupted follicular development...

View articletitled, Catalpol protects rat ovarian granulosa cells against oxidative stress and apoptosis through modulating the PI3K/Akt/mTOR signaling pathway

Articles

Stigmasterol alleviates cerebral ischemia/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats

Qilong Liang, Jun Yang, Jiaji He, Xiaoling Chen, Hong Zhang, Maolin Jia, Kai Liu, Chuangchuang Jia, Yanhong Pan, Jinwang Wei

Biosci Rep (2020) 40 (4): BSR20192133.

https://doi.org/10.1042/BSR20192133

Published: 15 April 2020

... and cleaved caspase-3 expression, and up-regulate Bcl-Xl expression. Conclusion: Stigmasterol protects the brain from brain I/R damage by reducing oxidative stress and inflammation. Correspondence: Jinwang Wei ( [email protected] ) 17 07 2019 27 02 2020 01 03 2020 09 03 2020...

View articletitled, Stigmasterol alleviates cerebral ischemia/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats

Articles

Apelin-13 alleviated cardiac fibrosis via inhibiting the PI3K/Akt pathway to attenuate oxidative stress in rats with myocardial infarction-induced heart failure

Shan Zhong, Hongli Guo, Hui Wang, Dan Xing, Tingting Lu, Jing Yang, Chen Wang

Biosci Rep (2020) 40 (4): BSR20200040.

https://doi.org/10.1042/BSR20200040

Published: 03 April 2020

... of MI rats and CFs with Ang II treatment. The results demonstrated that apelin-13 improved cardiac dysfunction, impaired cardiac hemodynamics, and attenuated fibrosis of CFs induced by Ang II via inhibiting the PI3K/Akt signaling pathway to inhibit oxidative stress. Correspondence: Chen Wang...

View articletitled, Apelin-13 alleviated cardiac fibrosis via inhibiting the PI3K/Akt pathway to attenuate oxidative stress in rats with myocardial infarction-induced heart failure

Articles

Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells

Xiaomin Liu, Xiaowen Zhao, Rong Cheng, Yusen Huang

Biosci Rep (2020) 40 (4): BSR20193006.

https://doi.org/10.1042/BSR20193006

Published: 31 March 2020

...Xiaomin Liu; Xiaowen Zhao; Rong Cheng; Yusen Huang Purpose: Autophagic dysfunction and abnormal oxidative stress are associated with cataract. The purpose of the present study was to investigate the changes of cellular autophagy and oxidative stress and their association in lens epithelial cells...

View articletitled, Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells

Includes: Supplementary data

Articles

The effect of wuling capsule on depression in Type 2 diabetic patients

Huanping Wang, Huizhen Chen, Yang Gao, Shengju Wang, Xian Wang, Xiaomei Tang, Wei Fang, Xiaoyan Shi, Jia Yao, Qiu Chen

Biosci Rep (2020) 40 (2): BSR20191260.

https://doi.org/10.1042/BSR20191260

Published: 18 February 2020

... were not statistically significant. Conclusion: Our results suggested that Wuling capsule ameliorated the depression in patients with T2DM, and also improved the state of inflammation and oxidative stress state. These results also strongly indicated the ability of clinical transformation of Wuling...

View articletitled, The effect of wuling capsule on depression in Type 2 diabetic patients

Articles

The pro- and anti-cancer effects of oxycodone are associated with epithelial growth factor receptor level in cancer cells

Yuqin Yu, Dapeng Li, Ji’an Duan, Hongshuang Xu, Li Li, Dengwu Tan, Hong Yan

Biosci Rep (2020) 40 (2): BSR20193524.

https://doi.org/10.1042/BSR20193524

Published: 07 February 2020

... of oxycodone in cancer cells. Materials and Methods: Proliferation, survival and migration assays were performed on multiple types of cancer cells. Epithelial growth factor receptor (EGFR)/ERK/Akt pathway and oxidative stress were investigated after oxycodone treatment. Results: Oxycodone can either stimulate...

View articletitled, The pro- and anti-cancer effects of oxycodone are associated with epithelial growth factor receptor level in cancer cells

Articles

Effect of lentivirus-mediated CFTR overexpression on oxidative stress injury and inflammatory response in the lung tissue of COPD mouse model

Xiaoli Xu, Huimin Huang, Xiangyi Yin, Hongmei Fang, Xiaoyue Shen

Biosci Rep (2020) 40 (1): BSR20193667.

https://doi.org/10.1042/BSR20193667

Published: 29 January 2020

...Xiaoli Xu; Huimin Huang; Xiangyi Yin; Hongmei Fang; Xiaoyue Shen We aimed to investigate the regulatory mechanism of lentivirus-mediated overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) in oxidative stress injury and inflammatory response in the lung tissue of mouse...

View articletitled, Effect of lentivirus-mediated CFTR overexpression on oxidative stress injury and inflammatory response in the lung tissue of COPD mouse model

Articles

MicroRNA files in the prevention of intestinal ischemia/reperfusion injury by hydrogen rich saline

Weifeng Yao, Xiaoyu Lin, Xue Han, Lanfen Zeng, Anshun Guo, Yu Guan, Ziqing Hei, Jianpei Liu, Pinjie Huang

Biosci Rep (2020) 40 (1): BSR20191043.

https://doi.org/10.1042/BSR20191043

Published: 24 January 2020

... License 4.0 (CC BY) . Inflammation Intestinal Ischemia/Reperfusion Injury Oxidative stress Ischemia/reperfusion (I/R) injury occurs in a tissue that undergoes a period of blood flow restriction followed by restoration [ 1 ]. The intestine is one of the organs that is most susceptible to I...

View articletitled, MicroRNA files in the prevention of intestinal ischemia/reperfusion injury by hydrogen rich saline

Includes: Supplementary data

Articles

Role of CyPA in cardiac hypertrophy and remodeling

Mengfei Cao, Wei Yuan, Meiling Peng, Ziqi Mao, Qianru Zhao, Xia Sun, Jinchuan Yan

Biosci Rep (2019) 39 (12): BSR20193190.

https://doi.org/10.1042/BSR20193190

Published: 23 December 2019

... death and cardiac dysfunction. Studies have shown that oxidative stress is an important mechanism for this maladaptation. Cyclophilin A (CyPA) is a member of the cyclophilin (CyPs) family. Many cells secrete CyPA to the outside of the cells in response to oxidative stress. CyPA from blood vessels...

View articletitled, Role of CyPA in cardiac hypertrophy and remodeling

Articles

Scutellarin attenuates hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1/Nrf2/ARE signaling

Haiyuan Wu, Lan Jia

Biosci Rep (2019) 39 (11): BSR20192501.

https://doi.org/10.1042/BSR20192501

Published: 13 November 2019

... importantly, excess production of reactive oxygen species (ROS) is considered as a critical factor in the genesis of reperfusion injury. The imbalance between the rate of generation of ROS and the ability to detoxify ROS may lead to oxidative stress and also evoke acute inflammatory response that will further...

View articletitled, Scutellarin attenuates hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1/Nrf2/ARE signaling

Includes: Supplementary data

Articles

Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro

Jiawei Xu, Haopeng Li, Kai Yang, Shuai Guo, Jie Wang, Chaoshuai Feng, Huayou Chen

Biosci Rep (2019) 39 (9): BSR20191711.

https://doi.org/10.1042/BSR20191711

Published: 20 September 2019

... through inducing oxidative stress injury. The present study provides new knowledge on NP cell senescence and helps us to better understand the mechanism of disc degeneration. Correspondence: Haopeng Li ( [email protected] ) 27 05 2019 16 08 2019 23 08 2019 30 08 2019...

View articletitled, Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro

Articles

The roles of reactive oxygen species and antioxidants in cryopreservation

Jia Soon Len, Wen Shuo Darius Koh, Shi-Xiong Tan

Biosci Rep (2019) 39 (8): BSR20191601.

https://doi.org/10.1042/BSR20191601

Published: 28 August 2019

... Cryopreservation oxidative stress reactive oxygen species The ability to keep an organism alive while frozen and allowing it to survive for a prolonged period of time may sound like a scene lifted directly from a science fiction movie. Although freezing complex multicellular organisms remains challenging...

View articletitled, The roles of reactive oxygen species and antioxidants in cryopreservation

Articles

Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway

Yao Ming-yan, Zhang Jing, Guo Shu-qin, Bai Xiao-liang, Li Zhi-hong, Zhou Xue

Biosci Rep (2019) 39 (8): BSR20190109.

https://doi.org/10.1042/BSR20190109

Published: 19 August 2019

... apoptosis by inhibiting oxidative stress and activate the PI3K/Akt/caspase-3 signaling pathway via GLP-1R. NPCs were treated according to the experiment grouping design, and 10 μM resveratrol was used as the positive control. After culturing the cells with HG and 0.5% FBS DMEM for 48 h...

View articletitled, Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway

Articles

Protective effects of delphinidin against H 2 O 2 –induced oxidative injuries in human retinal pigment epithelial cells

Timin Ni, Wanju Yang, Yiqiao Xing

Biosci Rep (2019) 39 (8): BSR20190689.

https://doi.org/10.1042/BSR20190689

Published: 15 August 2019

...Timin Ni; Wanju Yang; Yiqiao Xing Age-related macular degeneration (AMD) is now one of the leading causes of blindness in the elderly population and oxidative stress-induced damage to retinal pigment epithelial (RPE) cells occurs as part of the pathogenesis of AMD. In the present study, we...

View articletitled, Protective effects of delphinidin against H 2 O 2 –induced oxidative injuries in human retinal pigment epithelial cells

Articles

The microRNA in ventricular remodeling: the miR-30 family

Xiaonan Zhang, Shaoyang Dong, Qiujin Jia, Ao Zhang, Yanyang Li, Yaping Zhu, Shichao Lv, Junping Zhang

Biosci Rep (2019) 39 (8): BSR20190788.

https://doi.org/10.1042/BSR20190788

Published: 02 August 2019

..., oxidative stress, and inflammation. VR is commonly found in ischemic heart disease (IHD), hypertensive heart disease (HHD), diabetic cardiomyopathy (DCM), antineoplastic drug cardiotoxicity (CTX), and other CVDs. Therefore, we will review the relevant mechanisms of the miR-30 in VR induced by various...

View articletitled, The microRNA in ventricular remodeling: the miR-30 family

Articles

Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway

Yifan Wang, Zhexing Shou, Heng Fan, Meng Xu, Qianyun Chen, Qing Tang, Xingxing Liu, Hui Wu, Man Zhang, Ting Yu, Shuangjiao Deng, Yujin Liu

Biosci Rep (2019) 39 (7): BSR20182297.

https://doi.org/10.1042/BSR20182297

Published: 19 July 2019

... that OMT treatment could protect the integrity of the epithelial barrier, relieve oxidative stress, inhibit the expression of inflammatory mediators and pro-inflammatory cytokines, restrain the differentiation of Th17 cells and promote the differentiation of Treg cells via inhibition of the RhoA/ROCK...

View articletitled, Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway

Articles

Malondialdehyde on postoperative day 1 predicts postoperative cognitive dysfunction in elderly patients after hip fracture surgery

Chunxian Wu, Bin Gao, Yu Gui

Biosci Rep (2019) 39 (6): BSR20190166.

https://doi.org/10.1042/BSR20190166

Published: 20 June 2019

... 1.4 ± 1.0 1.3 ± 0.9 0.51 Symbol digit test 31.5 ± 10.8 32.4 ± 9.7 0.50 * P <0.05. Postoperative cognitive dysfunction hip fracture malondialdehyde oxidative stress biomarker Postoperative cognitive dysfunction (POCD), a condition that has been poorly...

View articletitled, Malondialdehyde on postoperative day 1 predicts postoperative cognitive dysfunction in elderly patients after hip fracture surgery

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