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1-26 of 26
Keywords: p53
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Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-2726_RET.
Published: 09 August 2024
... the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Gastiric cancer JNK signaling pathway p53 XEDAR ...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (7): BSR-2015-0122_RET.
Published: 03 July 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene regulation and bleomycin-induced stress genotoxic stress p53 Sin3...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (6): BSR20240389.
Published: 11 June 2024
... apparatus of the cell, particularly related to proliferation. The p53 protein plays an important role in regulating processes such as apoptosis, repair, and cell division, and the loss of its functionality often accompanies various types of tumors and contributes to the development of chemoresistance...
Articles
Libuše Kratochvilová, Matúš Vojsovič, Natália Valková, Lucie Šislerová, Zeinab El Rashed, Alberto Inga, Paola Monti, Václav Brázda
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (12): BSR20231348.
Published: 19 December 2023
... cerevisiae . To this aim, different G4 prone sequences were modeled to vary the chance of intramolecular G4 formation, analyzed in vitro by Thioflavin T binding test and circular dichroism and then placed at the yeast ADE2 locus on chromosome XV, downstream and adjacent to a P53 response element (RE...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (6): BSR-2019-0763_RET.
Published: 15 June 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Acute liver failure Immune function Macrophage microRNA-138 P53...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (8): BSR20220994.
Published: 16 August 2022
..., knockdown of UBA3 , UBE2M and RBX1 inhibited the NEDDylation of CULs and increased the protein expression of p53 and p21 in MOLM-13 cell line. In AML cells, MLN4924 inhibited cell proliferation, promoted cell apoptosis, and induced cell cycle arrest at the G 2 /M phase. As revealed by experiments in vivo...
Articles
Karla Gisel Calderon-González, Ixaura Medina-Medina, Lucia Haronikova, Lenka Hernychova, Ondrej Bonczek, Lukas Uhrik, Vaclav Hrabal, Borivoj Vojtesek, Robin Fahraeus, Jesús Hernández-Monge, Vanesa Olivares-Illana
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (7): BSR20220186.
Published: 04 July 2022
... stress, both are phosphorylated near to their RING domain, specifically at serine 403 and 395, respectively. Once phosphorylated, both can bind the p53 mRNA and enhance its translation; however, both recognize p53 protein and provoke its degradation under normal conditions. HDM2 has been well-recognized...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20201807.
Published: 18 August 2020
.... Ferrostatin-1 (Fer-1), an inhibitor of lipid peroxidation, inhibited Tan IIA caused-lipid peroxidation and Ptgs2 and Chac1 expression. In addition, Tan IIA also up-regulated p53 expression and down-regulated xCT expression. Tan IIA caused decreased intracellular glutathione (GSH) level and cysteine level...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20193949.
Published: 03 April 2020
... the apoptosis rate and apoptosis-related protein Bax and decreases Bcl-2. In addition, GINS2 knockdown induces an increase in the levels of p53 and growth arrest and DNA damage 45A (GADD45A). Co-transfection with GINS2-siRNA and siRNA against p53 (p53-siRNA) or co-transfection with GINS2-siRNA and siRNA against...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20194065.
Published: 25 March 2020
...-regulation of tumor suppressor proteins, p53 and Rb, as well as down-regulation of phospho Rb (pRb) protein. In addition, Bax, cytosolic cytochrome c and cleaved caspase-3 protein were increased while Bcl-2 protein was decreased significantly by 48 h of Colchicine treatment. These results implied...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (1): BSR20191488.
Published: 17 January 2020
... remains unexplored in CRC. We recently showed that SRPK2 promotes pancreatic cancer progression by down-regulating Numb and p53. Therefore, we investigated the cooperation between SRPK2, Numb and p53 in the cell migration, invasion and chemosensitivity of CRC in vitro . Here, we showed that SRPK2...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20192726.
Published: 24 December 2019
... proliferation and apoptosis were explored using MTT and Annexin-V/propidium iodide (PI) assays, respectively. The results revealed that the expression of XEDAR was decreased in gastric cancer tissues and in gastric cancer cell lines, and its expression is regulated by p53 in BGC-823 cells. Furthermore...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (9): BSR20191452.
Published: 06 September 2019
.... In the present study, we aimed to elucidate the anti-autophagy and anti-apoptosis effects of ginkgetin via nuclear factor κB (NF-κB)/p53 pathway in cerebral I/R rats. Methods : Rats were administrated 2-h occlusion of right middle cerebral artery before the 24-h reperfusion followed. There were three doses...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20190763.
Published: 19 July 2019
...-138 (miR-138) in acute liver failure (ALF) via a mechanism involving p53 and liver macrophage in a mouse model. The ALF mouse model was established using C57BL/6 male mice via tail vein injection of Concanamycin A (Con A) solution. The relationship between miR-138 and p53 was tested. The mononuclear...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20182407.
Published: 18 June 2019
...Lin Tan; Ling Sha; Ning Hou; Mei Zhang; Qian Ma; Chuanbing Shi Objectives: The present study investigated the correlation between α B-crystallin (CRYAB, HSPB5) and p53 expression in ovarian cancer and further analyzed the relationship between their expression and clinicopathology and the prognostic...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (2): BSR20181298.
Published: 08 February 2019
... have shown that synaptotagmin-7 (SYT7) expression was up-regulated in lung cancer. SYT7 also promoted the growth and colony formation of lung cancer cells and inhibited their senescence. In a molecular mechanism study, SYT7 was shown to interact with P53 and to potentiate the interaction between P53...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180271.
Published: 03 July 2018
... carcinoma cell)) cell apoptosis and proliferation inhibition via the p53 pathway. This interaction between imsnc761 and DDX6 also inhibited mitochondrial function and specific gene transcription and translation. To facilitate further research, we used label-free quantitation method to analyze the associated...
Articles
Journal:
Bioscience Reports
Biosci Rep (2016) 36 (5): e00378.
Published: 16 September 2016
... that much stronger apoptotic signal was found in OV-H1 hybrid cells inoculated mouse. The hESCs can inhibit the growth of OVCAR-3 cells in vitro by suppressing p53 and PTEN expression to suppress the growth of tumour that may be achieved by inducing apoptosis of OVCAR-3 cells. The change of epigenetics...
Articles
Irene López-Mateo, Amaia Arruabarrena-Aristorena, Cristina Artaza-Irigaray, Juan A. López, Enrique Calvo, Borja Belandia
Journal:
Bioscience Reports
Biosci Rep (2016) 36 (3): e00343.
Published: 03 June 2016
... signalling. HEY1 acts as a positive regulator of the tumour suppressor p53 via still unknown mechanisms. A MALDI-TOF/TOF MS analysis has uncovered a novel HEY1 regulatory phosphorylation event at Ser-68. Strikingly, this single phosphorylation event controls HEY1 stability and function: simulation of HEY1...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2016) 36 (1): e00293.
Published: 03 February 2016
...Shu Yang; Bo Wu; Haimei Sun; Fengqing Ji; Tingyi Sun; Yan Zhao; Deshan Zhou Tumour suppressor miR-34c deficiency resulted from hyper-methylation in its promoter is believed to be one of the main causes of colorectal cancer (CRC). Till date, miR-34c has been validated as a direct target of p53...
Includes: Supplementary data
Articles
Hye-Sook Seo, Jae Kyung Jo, Jin Mo Ku, Han-Seok Choi, Youn Kyung Choi, Jong-Kyu Woo, Hyo in Kim, Soo-yeon Kang, Kang min Lee, Koong Won Nam, Namkyu Park, Bo-Hyoung Jang, Yong Cheol Shin, Seong-Gyu Ko
Journal:
Bioscience Reports
Biosci Rep (2015) 35 (6): e00276.
Published: 22 December 2015
... 2015 22 9 2015 15 10 2015 23 10 2015 apigenin apoptosis breast cancer HER2 p53 STAT3 Phytoestrogens are a large group of plant-derived compounds and contain a phenolic ring which allows them to bind to the oestrogen receptor (ER), showing weak oestrogenic activity [ 1...
Articles
Journal:
Bioscience Reports
Biosci Rep (2015) 35 (4): e00234.
Published: 07 August 2015
... gene. Previously, an increased expression of Sin3B and tumour suppressor protein, p53 has been established upon adriamycin treatment. We, now provide evidence that Sin3B expression is significantly up-regulated under variety of stress conditions and this response is not stress-type specific. We...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2015) 35 (3): e00198.
Published: 11 June 2015
...Dámaso Sánchez-Carrera; Mikel García-Puga; Lucrecia Yáñez; Íñigo Romón; Carlos Pipaón Inactivation of p53 is one of the most relevant events in human cancer, since it allows transformed cells to escape their own proliferation control and leave them irresponsive to drugs that aim to damage their DNA...
Articles
Jerson L. Silva, Luciana P. Rangel, Danielly C. F. Costa, Yraima Cordeiro, Claudia V. De Moura Gallo
Journal:
Bioscience Reports
Biosci Rep (2013) 33 (4): e00054.
Published: 25 July 2013
...Jerson L. Silva; Luciana P. Rangel; Danielly C. F. Costa; Yraima Cordeiro; Claudia V. De Moura Gallo p53 is a key protein that participates in cell-cycle control, and its malfunction can lead to cancer. This tumour suppressor protein has three main domains; the N-terminal transactivation domain...
Articles
Journal:
Bioscience Reports
Biosci Rep (2010) 30 (5): 359–364.
Published: 03 June 2010
..., interfering with both intrinsic and extrinsic apoptotic pathways. In previous studies, we have demonstrated that the transforming growth factor β1-induced E2F-1/Mdm2 (murine double minute 2)/p53 apoptotic pathway was an upstream molecular target of UDCA. In agreement with this, we have recently established...
Articles
Journal:
Bioscience Reports
Biosci Rep (2010) 30 (5): 307–317.
Published: 09 April 2010
... ]. apoptosis breast cancer cell French bean haemagglutinin lectin p53 Lectins and HAs (haemagglutinins) are carbohydrate-binding proteins present in diverse organisms [ 1 – 3 ]. They display a number of biological activities such as antitumour [ 1 ], antifungal [ 4 ], antiviral [ 5...
