...Félix M. Goñi; Alicia Alonso In the past decade lipid vesicle fusion induced by either bacterial PC-preferring phospholipase C, phosphatidylinositol-specific phospholipase C, sphingomyelinase, or a combination of phospholipase C and sphingomyelinase has been demonstrated. In the present paper...

... properties, calvarial parathyroid hormone (PTH)-elicited adenylate cyclase (AC) and phospholipase C (PLC) activities, cross-sectional femoral area, as well as bone histomorphometry, were analyzed. Animals given Al displayed moderately enhanced serum Al and bone Al accumulation, however, DFO-treatment did...

.... Immunoblocking of their coupling to hormone receptors indicates that G q and/or G 11 confer throliberin (TRH) responsive phospholipase C (PL-C) activity in these cells. The contention was substantiated by immunoprecipitation analyses snowing that anti G q/11 α-sera coprecipitated PL-C activity. In essence, only...

... phospholipase C rat pituitary adenoma cells rat osteosarcoma cells 1,25 dihydroxy vitamin D 3 24,25 dihydroxy vitamin D 3 Abbreviations AC, adenylate cyclase; ALP, alkaline phosphatase; BGP, osteocalcin; BSA, bovine serum albumin; DA, dopamine; DAG, diacylglycerol; GH, growth hormone; GHRH...

... phosphatase respectively, and was fully mimicked by the phosphatidylinositol specific phospholipase C (PI-PLC), thus confirming the presence of a glycosyl-phosphatidylinositol anchoring-system for these exofacial enzymatic proteins. The complete inhibition of insulin dependent enzyme release by neomycin...

...L. M. Popescu; C. Cernescu; I. I. Moraru; St. N. Constantinescu; F. Baltã; M. Manciulea; E. Brãiloiu; L. Buzilã A monospecific inhibitory antibody directed to phospholipase C (phosphoinositidase C) blocked the antiviral effect of human interferons alpha and beta when tested on human quiescent...

...) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%) of PHA (10 μg/ml) or ConA (25 μg/ml) proliferative effects. Thus, the activation of membrane-bound PLC is a sine-qua-non condition for lectin-induced proliferation of T lymphocytes. The key-role of PLC...

.... Exogenous DAG (10 μM) stimulated protein synthesis within 1 hour. The results suggest that insuIin stimulates ribosomal activity through a signal mechanism that involves a G-protein mediated activation of phospholipase C to increase DAG levels. insulin protein synthesis G-protein diacylglycerol...