... under the Creative Commons Attribution License 4.0 (CC BY) . CHIP co-chaperone protein aggregation protein misfolding ubiquitin ligases The recessively inherited group of cerebellar ataxias (autosomal recessive cerebellar ataxia, ARCA) is commonly characterized by early onset...

...-associated transthyretin variant with human cardiac cells, compared with a non-disease associated transthyretin mutant may explain the basis of the early events of tissue damage in the transthyretin amyloidoses. amyloidosis cardiomyocytes cytotoxicity protein misfolding proteotoxicity...

... with different proteins. Such activities illustrate the flexibility and multifaceted functions of p53 variants. amyloid cancer p53 prions protein aggregation protein misfolding p53 is a tetrameric nuclear phosphoprotein that plays an essential role in the prevention of cancer development...