... and three 40% CR groups) and the CR groups were fed diets containing soya bean oil (also in the control diet), fish oil or lard. The fatty acid composition of the major mitochondrial phospholipid classes, proton leak and H 2 O 2 production were measured in liver mitochondria following 1 month of CR...

...Nadeene Parker; Antonio Vidal-Puig; Martin D. Brand Mild uncoupling of oxidative phosphorylation, caused by a leak of protons back into the matrix, limits mitochondrial production of ROS (reactive oxygen species). This proton leak can be induced by the lipid peroxidation products of ROS...

...Shu-sen Liu Recently, we proposed a hypothetical model of coexistence of “Reactive oxygen cycle” with Q cycle and H + cycle in mitochondrial respiratory chain to combine both processes of univalent electron leak for production of superoxide and of proton leak across inner mitochondrial membrane...

...David F. S. Rolfe; Martin D. Brand Mitochondrial proton leak is an important component of cellular metabolism in animals and may account for as much as one quarter to one third of the Standard Metabolic Rate of the rat. The activity of the proton leak pathway is different in a wide range of animal...