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Keywords: rheumatoid arthritis
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Articles

Clo-miR-14: a medicinally valued spice-derived miRNA with therapeutic implications in rheumatoid arthritis

Open Access
Ashish Sarkar, Mohd Saquib, Debolina Chakraborty, Sonia Mann, Swati Malik, Prachi Agnihotri, Lovely Joshi, Rajesh Malhotra, Sagarika Biswas
Journal: Bioscience Reports
Biosci Rep (2024) 44 (9): BSR20240311.
https://doi.org/10.1042/BSR20240311
Published: 10 September 2024
... regularly consumed spices, and validated one of the most potential miRNA ‘Clo-miR-14’ for its thermal stability, and absorption in the plasma samples of RA patient’s by RT-PCR. In vitro and in vivo studies were performed to investigate the effect of Clo-miR-14 in ameliorating rheumatoid arthritis (RA) like...
View articletitled, Clo-miR-14: a medicinally valued spice-derived miRNA with therapeutic implications in rheumatoid arthritis
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Includes: Supplementary data
Articles

Expression of Concern: SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Open Access
Journal: Bioscience Reports
Biosci Rep (2023) 43 (8): BSR-2018-0541_EOC.
https://doi.org/10.1042/BSR-2018-0541_EOC
Published: 31 August 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . fibroblast-like synoviocytes inflammation NF-κB rheumatoid arthritis...
View articletitled, Expression of Concern: SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway
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Articles

Expression of Concern: Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA GAS5

Open Access
Journal: Bioscience Reports
Biosci Rep (2023) 43 (8): BSR-2018-0626_EOC.
https://doi.org/10.1042/BSR-2018-0626_EOC
Published: 31 August 2023
... apoptosis GAS5 LncRNA rheumatoid arthritis The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an Expression of Concern to notify readers. It has been noted by a reader that there is a similarity...
View articletitled, Expression of Concern: Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA GAS5
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Articles

Anti-inflammatory activity of nicotine isolated from Brassica oleracea in rheumatoid arthritis

Open Access
Bharti Rakhecha, Prachi Agnihotri, Tikam Chand Dakal, Mohd Saquib, Monu, Sagarika Biswas
Journal: Bioscience Reports
Biosci Rep (2022) 42 (4): BSR20211392.
https://doi.org/10.1042/BSR20211392
Published: 21 April 2022
...Bharti Rakhecha; Prachi Agnihotri; Tikam Chand Dakal; Mohd Saquib; Monu; Sagarika Biswas Objectives: Rheumatoid arthritis (RA) is an autoimmune disease, associated with chronic inflammation of synoviocytes. Tumor necrosis factor α (TNF-α) plays a crucial role in the pathogenesis of RA through pro...
View articletitled, Anti-inflammatory activity of nicotine isolated from Brassica oleracea in rheumatoid arthritis
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Includes: Supplementary data
Articles

Retraction: MicroRNA-506 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targeting TLR4

Open Access
Journal: Bioscience Reports
Biosci Rep (2021) 41 (7): BSR-2018-2500_RET.
https://doi.org/10.1042/BSR-2018-2500_RET
Published: 28 July 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . fibroblast-like synoviocytes miR-506 Rheumatoid arthritis This article...
View articletitled, Retraction: MicroRNA-506 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targeting TLR4
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Articles

Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high‐throughput data

Open Access
Bin Zuo, JunFeng Zhu, Fei Xiao, ChengLong Wang, Yun Shen, XiaoDong Chen
Journal: Bioscience Reports
Biosci Rep (2020) 40 (12): BSR20193823.
https://doi.org/10.1042/BSR20193823
Published: 16 December 2020
...Bin Zuo; JunFeng Zhu; Fei Xiao; ChengLong Wang; Yun Shen; XiaoDong Chen Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are two major types of joint diseases. The present study aimed to identify hub genes involved in the pathogenesis and further explore the potential treatment targets...
View articletitled, Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high‐throughput data
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Includes: Supplementary data
Articles

Withdrawn: Lipid nanoparticles co-loaded with miRNA-22 and methotrexate for enhanced anti-inflammatory response in rheumatoid arthritis

Open Access
Hao Yuan, Ya-Meng Peng, Zhen-Yi Long, Si-Xian Wu, Yi-Feng Zhou
Journal: Bioscience Reports
Biosci Rep (2020) BSR20201735.
https://doi.org/10.1042/BSR20201735
Published: 03 December 2020
.... Rheumatoid arthritis methotrexate miR-22 inflammatory reactions apoptosis WITHDRAWN ARTICLE WITHDRAWN: Lipid nanoparticles co-loaded with miRNA-22 and methotrexate for enhanced anti-inflammatory response in rheumatoid arthritis Hao Yuan; Ya-Meng Peng; Zhen-Yi Long; Si-Xian Wu; Yi-Feng Zhou Biosci Rep...
View articletitled, Withdrawn: Lipid nanoparticles co-loaded with miRNA-22 and methotrexate for enhanced anti-inflammatory response in rheumatoid arthritis
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Articles

Identification of biomarkers associated with synovitis in rheumatoid arthritis by bioinformatics analyses

Open Access
Zhaoyan Li, Meng Xu, Ronghang Li, Zhengqing Zhu, Yuzhe Liu, Zhenwu Du, Guizhen Zhang, Yang Song
Journal: Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20201713.
https://doi.org/10.1042/BSR20201713
Published: 18 September 2020
...Zhaoyan Li; Meng Xu; Ronghang Li; Zhengqing Zhu; Yuzhe Liu; Zhenwu Du; Guizhen Zhang; Yang Song Objectives: Rheumatoid arthritis (RA) is the most common inflammatory arthritis in the world, but its underlying mechanism is still unclear. The present study aims to screen and verify the potential...
View articletitled, Identification of biomarkers associated with synovitis in rheumatoid arthritis by bioinformatics analyses
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Articles

The recombinant anti-TNF-α fusion protein ameliorates rheumatoid arthritis by the protective role of autophagy

Open Access
Xiaole Chen, Kaimei Nie, Xin Zhang, Shuangyu Tan, Qingmei Zheng, Yaduan Wang, Xiaofeng Chen, Zhiyu Tang, Rui Liu, Mengru Yan, Zhiwei Liu, Jianbo Lin, Jianhua Xu, Nanwen Zhang, He Wang, Juhua Yang
Journal: Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20194515.
https://doi.org/10.1042/BSR20194515
Published: 18 September 2020
... that the autophagy linked with TNF-α-induced apoptosis in response to rheumatoid arthritis. The results of the AIA rat model experiment presented that FVH1-1 can reduce the degree of joint swelling and inflammatory factors to a certain extent in vivo . Correspondence: Nanwen Zhang ( [email protected] ) or He...
View articletitled, The recombinant anti-TNF-α fusion protein ameliorates rheumatoid arthritis by the protective role of autophagy
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Articles

Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in rheumatoid arthritis

Open Access
Shanshan Yang, Wei Yin, Yan Ding, Fan Liu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20201273.
https://doi.org/10.1042/BSR20201273
Published: 18 August 2020
...Shanshan Yang; Wei Yin; Yan Ding; Fan Liu Backgrounds: Rheumatoid arthritis (RA) is a frequent autoimmune disease. Emerging evidence indicated that ZNFX1 antisense RNA1 (ZFAS1) participates in the physiological and pathological processes in RA. However, knowledge of ZFAS1 in RA is limited...
View articletitled, Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in rheumatoid arthritis
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Articles

Retraction: MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2

Open Access
Journal: Bioscience Reports
Biosci Rep (2020) 40 (8): BSR-20191136_RET.
https://doi.org/10.1042/BSR-20191136_RET
Published: 04 August 2020
..., alerting the Editorial Board to manipulation in Figure 8C. Rheumatoid arthritis microRNA-101-3p Prostaglandin-endoperoxide synthase 2 Fibroblast-like synoviocytes Synovial injury ...
View articletitled, Retraction: MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2
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Articles

RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis

Open Access
Jianting Wen, Jian Liu, Pingheng Zhang, Hui Jiang, Ling Xin, Lei Wan, Yue Sun, Dan Huang, Yanqiu Sun, Yan Long, Ying Zhang, Bingxi Bao, Guanghan Sun
Journal: Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20193160.
https://doi.org/10.1042/BSR20193160
Published: 03 April 2020
... expressed in many types of diseases. The present study aimed to determine the circRNAs specifically expressed in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients to identify their possible molecular mechanisms. Methods: To identify the circRNAs specifically expressed in RA...
View articletitled, RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis
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Includes: Supplementary data
Articles

MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2

Open Access
Qiaofeng Wei, Fang Lv, Hongju Zhang, Xinfang Wang, Qin Geng, Xiuying Zhang, Tongying Li, Shujun Wang, Yajuan Wang, Yanhui Cui
Journal: Bioscience Reports
Biosci Rep (2020) 40 (1): BSR20191136.
https://doi.org/10.1042/BSR20191136
Published: 14 January 2020
...Qiaofeng Wei; Fang Lv; Hongju Zhang; Xinfang Wang; Qin Geng; Xiuying Zhang; Tongying Li; Shujun Wang; Yajuan Wang; Yanhui Cui Objective: Rheumatoid arthritis (RA) is the most frequently occurring inflammatory arthritis. The present study was performed to characterize the role of microRNA-101-3p...
View articletitled, MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2
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Articles

IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

Open Access
Menglei Yu, Jingyi Hou, Minghui Zheng, Yi Cao, Yamuhanmode Alike, Yuanyuan Mi, Jie Zhu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (1): BSR20191449.
https://doi.org/10.1042/BSR20191449
Published: 06 January 2020
...Menglei Yu; Jingyi Hou; Minghui Zheng; Yi Cao; Yamuhanmode Alike; Yuanyuan Mi; Jie Zhu Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous...
View articletitled, IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility
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Articles

MiR-129-5p regulates cell proliferation and apoptosis via IGF-1R/Src/ERK/Egr-1 pathway in RA-fibroblast-like synoviocytes

Open Access
Yan Zhang, Ni Yan, Xiaoqing Wang, Yanhai Chang, Yu Wang
Journal: Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20192009.
https://doi.org/10.1042/BSR20192009
Published: 28 November 2019
...Yan Zhang; Ni Yan; Xiaoqing Wang; Yanhai Chang; Yu Wang It is reported that miR-129-5p plays an important role in various diseases, but its effect on rheumatoid arthritis (RA) and the potential mechanism remain to be clarified. In the present research, we aimed to investigate the effect of miR-129...
View articletitled, MiR-129-5p regulates cell proliferation and apoptosis via IGF-1R/Src/ERK/Egr-1 pathway in RA-fibroblast-like synoviocytes
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Articles

FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways

Open Access
Nanwen Zhang, Zhiwei Liu, Hongbin Luo, Weifang Wu, Kaimei Nie, Lin Cai, Shuangyu Tan, Xiaole Chen, Ying Huang, Jiaxing Liu, Meina Lv, Xin Zhang, Yun Fan, Yuying Lin, Shennan Ye, Yang Liu, Lixian Wu, Jianhua Xu
Journal: Bioscience Reports
Biosci Rep (2019) 39 (9): BSR20182263.
https://doi.org/10.1042/BSR20182263
Published: 03 September 2019
...Nanwen Zhang; Zhiwei Liu; Hongbin Luo; Weifang Wu; Kaimei Nie; Lin Cai; Shuangyu Tan; Xiaole Chen; Ying Huang; Jiaxing Liu; Meina Lv; Xin Zhang; Yun Fan; Yuying Lin; Shennan Ye; Yang Liu; Lixian Wu; Jianhua Xu Background: Rheumatoid arthritis (RA) is a chronic articular synovial inflammatory...
View articletitled, FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways
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Articles

Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

Open Access
Kewei Ren, Jilei Tang, Luming Nong, Nan Shen, Xiaolong Li
Journal: Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20190110.
https://doi.org/10.1042/BSR20190110
Published: 15 August 2019
...Kewei Ren; Jilei Tang; Luming Nong; Nan Shen; Xiaolong Li Controversial results concerning the association between a polymorphism rs6822844 in the interleukin (IL) 21 (IL-21) gene and rheumatoid arthritis (RA) have existed. A meta-analysis to confirm above relationships is necessary to be performed...
View articletitled, Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility
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Articles

MiR-26a-5p enhances cells proliferation, invasion, and apoptosis resistance of fibroblast-like synoviocytes in rheumatoid arthritis by regulating PTEN/PI3K/AKT pathway

Open Access
Zhengping Huang, Shan Xing, Meng Liu, Weiming Deng, Yunqing Wang, Zhixiang Huang, Yukai Huang, Xuechan Huang, Chiwei Wu, Xin Guo, Xia Pan, Jiawei Jiang, Fan Feng, Tianwang Li
Journal: Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20182192.
https://doi.org/10.1042/BSR20182192
Published: 26 July 2019
... arthritis (RA). MiRNAs are closely involved in a variety of pathologic conditions. In the present study, we aimed to screen for the aberrant expression of miRNAs in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) to further identify the altered expression of miR-26a-5p in RA-FLS...
View articletitled, MiR-26a-5p enhances cells proliferation, invasion, and apoptosis resistance of fibroblast-like synoviocytes in rheumatoid arthritis by regulating PTEN/PI3K/AKT pathway
Open the PDF for MiR-26a-5p enhances cells proliferation, invasion, and apoptosis resistance of fibroblast-like synoviocytes in rheumatoid arthritis by regulating PTEN/PI3K/AKT pathway in another window
Includes: Supplementary data
Articles

Differential gene expression in articular cartilage between rheumatoid arthritis and endemic Kashin–Beck disease

Open Access
Zongqiang Gao, Chen Duan, Fang-fang Yu, Xiong Guo
Journal: Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20190188.
https://doi.org/10.1042/BSR20190188
Published: 28 June 2019
...Zongqiang Gao; Chen Duan; Fang-fang Yu; Xiong Guo Kashin–beck disease (KBD) is endemic chronic osteoarthrosis and its pathogenesis is still unclear. The present study aimed to explore differential gene expression in articular cartilage between patients with rheumatoid arthritis (RA) and KBD...
View articletitled, Differential gene expression in articular cartilage between rheumatoid arthritis and endemic Kashin–Beck disease
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Articles

MiRNA-506 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targetting TLR4

Open Access
Dan Li, Qingchen Zhou, Gaojian Hu, Gang Wang
Journal: Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20182500.
https://doi.org/10.1042/BSR20182500
Published: 07 May 2019
...Dan Li; Qingchen Zhou; Gaojian Hu; Gang Wang Fibroblast-like synoviocytes (FLSs) play a crucial role in rheumatoid arthritis (RA) pathogenesis. While miRNA (miR)-506 has been implicated in the progression of multiple diseases, its role in RA remains to be explored. The present study evaluated...
View articletitled, MiRNA-506 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targetting TLR4
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Articles

LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6

Open Access
Guan Wang, Lian Tang, Xihai Zhang, Yao Li
Journal: Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20182374.
https://doi.org/10.1042/BSR20182374
Published: 02 May 2019
...Guan Wang; Lian Tang; Xihai Zhang; Yao Li IL-6 produced by human fibroblast-like synoviocytes (HFLS) promotes rheumatoid arthritis (RA), while lncRNA DILC regulates liver cancer stem cells by inhibiting IL-6. Therefore, lncRNA DILC may participate in RA. In the present study, we found that plasma...
View articletitled, LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6
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Articles

miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2

Open Access
Kai Liu, Yingang Zhang, Liang Liu, Qiling Yuan
Journal: Bioscience Reports
Biosci Rep (2019) 39 (1): BSR20180890.
https://doi.org/10.1042/BSR20180890
Published: 08 January 2019
...Kai Liu; Yingang Zhang; Liang Liu; Qiling Yuan The present study aimed to explore miR-125 effects on rheumatoid arthritis (RA) development to provide a potential target for RA. Briefly, rat RA model was established (Model group) by injection of Freund’s Complete Adjuvant into the left hind toe...
View articletitled, miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2
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Articles

MiR-199a-3p inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via suppressing retinoblastoma 1

Open Access
Yufan Wangyang, Linhong Yi, Tao Wang, Yanbo Feng, Guangwang Liu, Dongya Li, Xin Zheng
Journal: Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20180982.
https://doi.org/10.1042/BSR20180982
Published: 14 November 2018
...Yufan Wangyang; Linhong Yi; Tao Wang; Yanbo Feng; Guangwang Liu; Dongya Li; Xin Zheng Background Fibroblast-like synoviocytes (FLSs) that line the intimal synovium play a crucial role in the pathogenesis of rheumatoid arthritis (RA). miR-199a-3p is a highly conserved miRNA that has been shown...
View articletitled, MiR-199a-3p inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via suppressing retinoblastoma 1
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Articles

Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by up-regulating lncRNA GAS5

Open Access
Guoqing Li, Ying Liu, Fanru Meng, Zhongbin Xia, Xia Wu, Yuxuan Fang, Chunwang Zhang, Dan Liu
Journal: Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20180626.
https://doi.org/10.1042/BSR20180626
Published: 05 October 2018
...Guoqing Li; Ying Liu; Fanru Meng; Zhongbin Xia; Xia Wu; Yuxuan Fang; Chunwang Zhang; Dan Liu Rheumatoid arthritis (RA) is a common chronic autoimmune joint disease characteristic of elevated proliferation and infiltration of fibroblast-like synoviocytes (FLS). Here, we aimed to explore...
View articletitled, Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by up-regulating lncRNA GAS5
Open the PDF for Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by up-regulating lncRNA GAS5 in another window
Includes: Supplementary data
Articles

Decreased MiR-128-3p alleviates the progression of rheumatoid arthritis by up-regulating the expression of TNFAIP3

Open Access
Zhongbin Xia, Fanru Meng, Ying Liu, Yuxuan Fang, Xia Wu, Chunwang Zhang, Dan Liu, Guoqing Li
Journal: Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180540.
https://doi.org/10.1042/BSR20180540
Published: 31 July 2018
...Zhongbin Xia; Fanru Meng; Ying Liu; Yuxuan Fang; Xia Wu; Chunwang Zhang; Dan Liu; Guoqing Li Background: Rheumatoid arthritis (RA) is a inflammatory disease that characterized with the destruction of synovial joint, which could induce disability. Inflammatory response mediated the RA. It has been...
View articletitled, Decreased MiR-128-3p alleviates the progression of rheumatoid arthritis by up-regulating the expression of TNFAIP3
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Articles

SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Open Access
Guoqing Li, Zhongbing Xia, Ying Liu, Fanru Meng, Xia Wu, Yuxuan Fang, Chunwang Zhang, Dan Liu
Journal: Bioscience Reports
Biosci Rep (2018) 38 (3): BSR20180541.
https://doi.org/10.1042/BSR20180541
Published: 21 June 2018
...Guoqing Li; Zhongbing Xia; Ying Liu; Fanru Meng; Xia Wu; Yuxuan Fang; Chunwang Zhang; Dan Liu Rheumatoid arthritis (RA) is an autoimmune disease of the joints characterized by synovial hyperplasia and chronic inflammation. Fibroblast-like synoviocytes (FLS) play a central role in RA initiation...
View articletitled, SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway
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