...Xiaowei Zhong; Wenting Guo; Jinhong Wei; Yijun Tang; Yingjie Liu; Joe Z. Zhang; Vern Hsen Tan; Lin Zhang; Ruiwu Wang; Peter P. Jones; Carlo Napolitano; Silvia G. Priori; S.R. Wayne Chen Mutations in cardiac ryanodine receptor (RyR2) are linked to catecholaminergic polymorphic ventricular...

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Intracellular calcium mitochondrial ROS Ryanodine receptor The authors...

...Dapeng Dong; Qiongyu Hao; Ping Zhang; Tao Wang; Fei Han; Xiaodong Liang; Zhenghua Fei Mitochondrial reactive oxygen species (ROS) cause Ca 2+ release from the endoplasmic reticulum (ER) via ryanodine receptors (RyRs) in pulmonary artery smooth muscle cells (PASMCs), playing an essential role...

..., this peptide selectively inhibits the Drosophila Shaker K + channel but is not capable of activating skeletal-type Ca 2+ release channels/ryanodine receptors, which is remarkably different from the previously known scorpion venom ICK peptides. The removal of two C-terminal residues of λ-MeuKTx-1 led...

... surgery. Susceptibility to MH results from mutations in Ca 2+ channel proteins that mediate excitation–contraction (EC) coupling, with the ryanodine receptor Ca 2+ release channel (RyR1) representing the major locus. Here we review recent studies characterizing the effects of MH mutations...

... protein-protein interactions that lead to activation of the sarcoplasmic reticulum (SR) ryanodine receptor (RyR)/Ca 2+ release channel by the voltage-sensing transverse (T−) tubule dihydropyridine receptor (DHPR)/Ca 2+ channel. In a subsequent step, the released Ca 2+ amplify SR Ca 2+ release...