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Keywords: sFlt-1
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Articles

sFlt-1 impairs neurite growth and neuronal differentiation in SH-SY5Y cells and human neurons

Open Access
Aaron Barron, Lauren Barrett, Jetro J. Tuulari, Linnea Karlsson, Hasse Karlsson, Cathal M. McCarthy, Gerard W. O'Keeffe
Journal: Bioscience Reports
Biosci Rep (2024) 44 (5): BSR20240562.
https://doi.org/10.1042/BSR20240562
Published: 17 May 2024
... mechanisms mediating this relationship are currently unknown, and one potential candidate is the anti-angiogenic factor soluble Fms-like tyrosine kinase 1 (sFlt-1), which is highly elevated in PE. While sFlt-1 can impair angiogenesis via inhibition of VEGFA signalling, it is unclear whether it can directly...
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Articles

Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells

Open Access
Adrian C. Eddy, Heather Chapman, David T. Brown, Eric M. George
Journal: Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20193252.
https://doi.org/10.1042/BSR20193252
Published: 25 February 2020
...Adrian C. Eddy; Heather Chapman; David T. Brown; Eric M. George Despite years of study, the gestational disorder preeclampsia (PE) remains poorly understood. One proposed mechanism of PE development is increased soluble VEGF receptor-1 (sFlt-1), ultimately causing angiogenic imbalance...
View articletitled, Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells
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