.... intervertebral disc nucleus pulposus osmolarity oxidative stress senescence © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Following...

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . intervertebral disc degeneration nucleus pulposus p38 MAPK pH senescence...

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . compression degeneration nucleus pulposus organ culture senescence...

... ) The authors have been contacted in regard to the retraction, and disagree with the Journal's decision to retract the article. Given the extent of the issues raised, the Editorial Board stand by the decision to retract the article. compression interverbral disc nucleus pulposus p38-MAPK senescence...

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . annulus fibrosus cell autophagy mechanical tension senescence...

... resveratrol senescence This article is one of twenty-five publications being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting the Editorial Office to suspected misconduct in three...

...Pengfei Tong; Jingke Zhang; Shuang Liu; Jiyang An; Gehan Jing; Laifeng Ma; Ruihua Wang; Zhengfeng Wang Vascular endothelial cell premature senescence plays an important part in stroke. Many microRNAs (miRNAs) are known to be involved in the pathological process of vascular endothelial cell...

...Tareq Saleh; Ahmad Alhesa; Mahmoud Al-Balas; Omar Abuelaish; Ahmad Mansour; Heyam Awad; Mohammed El-Sadoni; Valerie J. Carpenter; Bilal Azab Senescence is a cell stress response induced by replicative, oxidative, oncogenic, and genotoxic stresses. Tumor cells undergo senescence in response...

...Jiawei Xu; Haopeng Li; Kai Yang; Shuai Guo; Jie Wang; Chaoshuai Feng; Huayou Chen Nucleus pulposus (NP) cell senescence is involved in disc degeneration. The in situ osmolarity within the NP region is an important regulator of disc cell’s biology. However, its effects on NP cell senescence remain...

...–50 mg/l TMP for 4 days significantly increased cell viability, alleviated senescence by suppressing NF-κB signaling, and promoted bMSC proliferation by regulating the cell cycle. In addition, 40–50 mg/l TMP treatment may facilitate the neuronal differentiation of bMSCs, verified in the present study...

...Xiaofang Yu; Yucang He; Zhuojie Chen; Yao Qian; Jingping Wang; Ziwan Ji; Xiaoyan Tan; Liqun Li; Ming Lin Background: Adipose-derived stem cells have attracted significant interest, especially in stem cell therapy and regenerative medicine. However, these cells undergo gradual premature senescence...

...Junsheng He; Ailiang Zhang; Zhiwen Song; Shiwu Guo; Yuwei Chen; Zhiyuan Liu; Jinlong Zhang; Xu Xu; Jinbo Liu; Lei Chu Objective: The senescence of nucleus pulposus (NP) cells induced by oxidative stress is one of the important causes of intervertebral disc degeneration (IDD). Herein, we...

... to investigate AF cell senescence under mechanical tension and the potential role of autophagy. Methods: Rat AF cells were cultured and experienced different magnitudes (5% elongation and 20% elongation) of mechanical tension for 12 days. Control AF cells were kept static. Cell proliferation, telomerase activity...

...Zhenhua Fei; Wei Gao; Raoying Xie; Ganzhu Feng; Xiaolin Chen; Yiyan Jiang Lung cancer has been one of the most common malignancies in the world. Cell senescence has been recognized as the avenue to inhibit tumor progression. However, the mechanisms remain poorly understood. In the present study, we...

...Jiabin Fu; Wei Yu; Dianming Jiang Background: Nucleus pulposus (NP) cell senescence is an important cellular feature within the degenerative disc. It is known that a very acidic niche exists in the degenerative disc, which participates in regulating disc cell viability and matrix metabolism...

...Wenping Wang; Pei Li; Jiagang Xu; Xiangkun Wu; Zhiliang Guo; Lijing Fan; Ruipeng Song; Jianli Wang; Li Wei; Haijun Teng Background: Diabetes mellitus is closely correlated with disc degeneration. Nucleus pulposus (NP) cell apoptosis and senescence are typical cellular features within...

...Jianmin Shi; Lianglong Pang; Shouguo Jiao Mechanical stimuli obviously affect disc nucleus pulposus (NP) biology. Previous studies have indicated that static compression exhibits detrimental effects on disc biology compared with dynamic compression. To study disc NP cell senescence under static...

...Lianglong Pang; Pei Li; Ruijie Zhang; Yuan Xu; Lei Song; Qiang Zhou Nucleus pulposus (NP) cell senescence is a typical pathological feature within the degenerative intervertebral disc. As a potential inducing and aggregating factor of disc degeneration, mechanical overloading affects disc biology...

... Cancer Foundation-7) breast adenocarcinoma cells with MELK-T1 induced the accumulation of stalled replication forks and double-strand breaks that culminated in a replicative senescence phenotype. This phenotype correlated with a rapid and long-lasting ataxia telangiectasia-mutated (ATM) activation...

... the effects of tumour necrosis factor (TNF)-α-mediated NF-κB (nuclear factor kappa-light-chain-enhancer of activated B-cells) activation on E2-induced senescence in HPV16-integrated SiHa cells. The results show that E2 inhibits endogenous E6 gene expression and sensitizes SiHa cells to TNF-α-induced NF-κB...

... that such interaction results in the abrogation of mortalin-p53 interaction leading to nuclear translocation and transcriptional reactivation of p53 function that results in an induction of senescence in cancer cells. 1 These authors contributed equally to this work. 2 Correspondence may be addressed...

... by which it took effects. The expression of GNAO1 was detected by IHC (immunohistochemistry) and real-time qPCR (quantitative PCR). Cell proliferation test and cell senescence test were then performed to explore the role of GNAO1 in the occurrence and development of HCC. It was revealed that the level...

... was measured using an Annexin V/PI (propidium iodide) kit, the cell cycle was analysed by flow cytometry and cell senescence was detected using senescence β-galactosidase staining. The intracellular expression of NF-κB p65 protein was studied by cytochemistry. The expression levels of NF-κB p65, p50, c-Rel...

... of the cells. Interestingly, the increase in RAR-β expression is not associated with telomere shortening, a typical biomarker of cellular senescence. In the present study, we also describe a protocol for characterizing RAR-β–ligand interactions using nuclear extract from late passage HRPE cells as a source...