... factors for steroid hormone signal transduction. Accordingly, SIRT1 and its orthologues, Sir2 and Sir-2.1, are shown to be veritable nuclear receptor coregulators that classically coactivate the oestrogen receptor in the absence of ligand; coactivation was further increased by 17β-oestradiol. Remarkably...

... The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Hippo pathway phosphorylation phosphatase Signal transduction tumor suppressors...

... under the Creative Commons Attribution License 4.0 (CC BY) . hepatoma-derived growth factor mechanical stretch signal transduction vascular smooth muscle vascular injury Hepatoma-derived growth factor (HDGF) is a ubiquitous growth factor originally isolated from conditioned medium of Huh...

... of membrane protein assembly and function in signal transduction pathways that control multiple cellular responses. Different signal transduction pathways are simultaneously activated by VEGFR–VEGF complexes with membrane trafficking along the endosome–lysosome network further modulating signal output from...

.../ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cytokine antagonist growth hormone growth hormone receptor glycosylphosphatidylinositol anchor signal transduction receptor trafficking GPI anchors...

.... cancer chemoresistance chemosensitivity clinical prognosis signal transduction tumour suppressor gene (TSG) Cancer is one of the leading causes of human death worldwide, accounting for 7.6 million deaths each year (World Health Organization, 2008). Various therapies have been developed to treat...

... messenger involved in signal transduction. PLC is known to be activated on TNFR stimulation [ 116 – 118 ] and the resulting second messengers such as DAG are extremely relevant in the downstream signal transduction events, like the activation of PKC [ 119 ]. TNFRs also known as DRs are known to induce...

... of the thrombopoietin-independent parent cell line Ba/F3. The thrombopoietin-mimetic compounds elicited signal-transduction responses comparable with recombinant human thrombopoietin, such as tyrosine phosphorylation of the thrombopoietin receptor, JAK (Janus kinase) 2, Tyk2 (tyrosine kinase 2), STAT (signal transducer...

.... Among lipids, sphingolipids (in particular glycolipids and sphingomyelin) are characteristically enriched within such domains. Moreover, a series of functionally related proteins is present, suggesting the involvement of these membrane structures in the mechanism of signal transduction and lipid/protein...

... internal energy levels in the bacteria. KEY WORDS: oxygen receptors; bacterial chemotaxis; reactive oxygen species; signal transduction. INTRODUCTION In the presence of high oxygen concentrations, bacteria employ multiple strategies to protect against reactive oxygen derivatives that are generated...

...Ruslan N. Grishanin; Sergei I. Bibikov Since 1881 when Englemann reported aerotaxis in bacteria, an understanding of the molecular nature of the signal transduction remains a daring goal for microbiologists. This short review discusses known facts and recent advances in the field including...

...Peter C. Newell This review is concerned with the roles of cyclic GMP and Ca 2+ ions in signal transduction for chemotaxis of Dictyostelium . These molecules are involved in signalling between the cell surface cyclic AMP receptors and cytoskeletal myosin II involved in chemotactic cell movement...

...John J. M. Bergeron; G. M. Di Guglielmo; Patricia C. Baass; François Authier; Barry I. Posner Upon the binding of insulin or epidermal growth factor to their cognate receptors on the liver parenchymal plasmalemma, signal transduction and receptor internalization are near co-incident. Indeed...

... hepatocytes (4 h–24 h after partial hepatectomy) to determine whether the signal transduction is the same in quiescent proliferating and differentiating cells. The epinephrine treatment causes a significative cytosolic calcium transient in hepatocytes isolated in the last day of fetal life (22-day old...

... an oscillating or fluctuating electric field can be used by an enzyme to drive a chemical reaction away from equilibrium. In vivo , the stationary transmembrane potential of a cell must be modulated to become “locally” oscillatory if it is to derive energy and signal transduction processes. 13 4 1988...

... phospholipase C signal transduction 12 6 1987 © 1987 Plenum Publishing Corporation 1987 Bioscience Reports, Vol. 7, No. 7, 1987 Effects of Insulin, Pertussis Toxin and Cholera Toxin on Protein Synthesis and Diacylglycerol Production in 3T3 Fibroblasts: Evidence for a G-protein Mediated...

... little effect on the response to serum or the later response to insulin. Acute phorbol ester treatment stimulated protein synthesis. 27 8 1986 © 1986 Plenum Publishing Corporation 1986 insulin serum protein synthesis protein kinase C 3T3 fibroblasts signal transduction...