...Andrea Muñoz-Ayala; Brenda Chimal-Vega; Nicolás Serafín-Higuera; Octavio Galindo-Hernández; Gladys Ramírez-Rosales; Iván Córdova-Guerrero; Luis Fernando Gómez-Lucas; Victor García-González Objective: Estrogen receptor-positive (ER+) breast cancer represents about 80% of cases, tamoxifen...

...Yanyan Wang; Xiaonan Gong; Yujie Zhang Tamoxifen is an estrogen receptor (ER) antagonist that is most commonly used for the treatment of ER-positive breast cancer. However, tamoxifen resistance remains a major cause of cancer recurrence and progression. Here, we aimed to identify hub genes...

... and vitamin D receptor (VDR) expression on the tamoxifen resistance of CSCs. Methods: MCF-7 cells were treated with 1,25(OH) 2 D 3 and their levels of VDR expression, viability, and apoptosis were detected. CD133 + MCF-7 stem cells were identified and transfected with a VDR-overexpression plasmid...

...Pengpeng Yan; Huanna Tang; Xiaoying Chen; Shuiyu Ji; Wei Jin; Jiaming Zhang; Jia Shen; Hao Deng; Xiang Zhao; Quanquan Shen; Hongfeng Huang Peritoneal fibrosis is a severe complication arising from long-term peritoneal dialysis (PD). Tamoxifen (Tamo) has been clinically proven effective in a series...

...Fulvia Farabegoli; Alessio Papi; Marina Orlandi The activation of the EGFR (epidermal growth factor receptor) signalling pathway is one of the key mechanisms underlying the development of resistance to tamoxifen in breast cancer patients. As EGCG [(–)-epigallocatechin-3-gallate], the most active...

...Nadide Kazanci; Feride Severcan Tamoxifen (TAM) is a non-steroidal antiestrogen drug, which is widely used to prevent and treat breast, liver, pancreas and brain cancers. The present work investigates, in detail, the concentration dependent behavior of TAM (varying from 1 mol% to 45 mol...

... of the factors in this discrepancy. Turbidity(absorbance at 440 nm) and Fourier transform infrared spectroscopicstudies reveal that tamoxifen causes opposite effects on membranefluidity at low (1 mol.%) and high (30 mol.%) tamoxifen concentrations. Lowtamoxifen concentrations increase the absorbance in the gel...