...Tian Hu; Yan Zhao; Yan Long; Xiaoqing Ma; Ya Zeng; Weijie Wu; Chongtian Deng; Mengling Li; Siyuan Peng; Hanzhi Yang; Mi Zhou; Jinyue Hu; Yueming Shen Endoplasmic reticulum (ER) stress contribute to inflammatory bowel disease (IBD). However, the mechanistic link between toll-like receptor 4 (TLR4...

... histiocytoma amplified sequence 1 (MFHAS1) in DN. Method: Mouse mesangial cells (MMCs) were treated with low glucose (LG) or high glucose (HG). TAK242 or short hairpin TLR4 (shTLR4) were employed to down-regulate Toll-like receptor 4 (TLR4). The effect of MFHAS1 knockdown or overexpression on fibrosis-related...

... to the 3′-untranslated region (UTR) of Toll-like receptor (TLR) 4 (TLR4), and overexpression of TLR4 largely rescued the miR-216a-5p-mediated suppression of rTp17-induced inflammatory cytokine production and the TLR4-MYD88 signaling pathway. Thus, our results reveal a novel role of miR-216a-5p-containing...

...-regulation in RA-FLSs significantly inhibited the proliferation and promoted cell cycle arrest at the G 0 /G 1 phase. The overexpression of miR-506 induced apoptosis, along with an increase in activities of caspase-3 and -8. A target gene Toll-like receptor 4 ( TLR4 ) under the direct regulation of miR-506...