... may be structured and show how novel RNA structures may influence RNA processing including splicing and polyadenylation. RNA structures can be targeted therapeutically to treat disease. alternative splicing polyadenylation precursor RNA RNA structure splicing transcription...

... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarkers cancer molecular basis of health and disease transcription Multimerin-1 (MMRN1) is a member of the EMILIN/multimerin family of proteins, found in platelets...

... alteration. Pro-Hyp also promotes the production of a regulator of osteoblast differentiation, Runt-related transcription factor 2 (Runx2), through Foxg1, inducing osteoblast differentiation. In addition, Pro-Hyp disrupts the interaction between Foxg1 and Runx2, and Foxg1 appears to interact with Runx2...

...Yan Peng; Xin Huang; Tianfang Huang; Feng Du; Xin Cui; Zhuo Tang Herein, Broccoli/ mCherry and an EGFP / mCherry dual-color fluorescent reporting systems have been established to quantify the promoter activity at transcription and translation levels in eukaryotic cells. Based on those systems, four...

... but unmethylated pre-mRNA [ 12 , 13 ]. In S. cerevisiae , there are partially redundant machineries for RNA cap quality control: Rai1-Rat1 and Ydr370C/Dxo1 [ 11 , 14–16 ]. Capping occurs co-transcriptionally with the capping and transcriptional machineries being tightly coupled. Below, we describe current...

... the Creative Commons Attribution License 4.0 (CC BY) . cellular localization exocytosis myosins protein-protein interactions trafficking transcription Class V myosins are processive motors that transport or tether vesicles, organelles, and macromolecules to actin filaments, and play key...

... the functional impact of G1 and G2 alleles on the transcription and translation of APOL1 mRNA. Apolipoprotein genetic variants kidney diseases transcription translation Long before the onset of any disease, the microenvironment in a normal cell starts changing to promote transformation of the normal...

... proliferation. However, the molecular mechanisms that regulate PDE3A gene expression remain largely unknown. In the present study, we investigated the transcriptional regulation of PDE3A , and found that the splicing factor proline- and glutamine-rich (SFPQ) protein modulated PDE3A mRNA levels. Multiple...

... expression. Cells were cultured under differential conditions to generate M1/M2 macrophages. In the macrophages, opioid secretory capacity was shown to be diminished. Finally, Dragon (repulsive guidance molecule b, RGMb) expression was shown diminished in M1 macrophages, which serves as a key transcriptional...

... transcriptional activator of the mitochondrial genome is mitochondrial transcription factor A (Tfam); however, the regulation of Tfam expression during muscle differentiation is not known. Thus, we measured Tfam mRNA levels, mRNA stability, protein expression and localization and Tfam transcription during...

...Shih Ying Chung; Wei Chieh Huang; Ching Wen Su; Kuan Wei Lee; Hsiang Cheng Chi; Cheng Tao Lin; Szu-Tah Chen; Kai Min Huang; Mu Shiun Tsai; Hui Peng Yu; Shen Liang Chen Transcription factors of the FoxO (forkhead box O) family regulate a wide range of cellular physiological processes, including...

... is known about the transcriptional regulation and the promoter of this important tumour suppressor. So far the following is the first comprehensive study to describe the regulation of Pdcd4 transcription by ZBP-89 (zinc-finger-binding protein 89), besides characterizing the gene promoter. We identified...

... 2011 alkaloid circadian rhythm harmine nutrition transcription Conventional real-time reporter assays represent a convenient method of monitoring effects on circadian rhythm, and many genes that are expressed in a circadian fashion were originally identified using such assays. We...

... the transcriptional regulation of the BMAL1 gene, a critical component of the mammalian clock system to investigate the possibility of using HSG cells as a model system of the submandibular clock. The BMAL1 gene was expressed with circadian oscillation after stimulation with dexamethasone, and its regulatory region...

... in the central nervous system. We have previously cloned the chicken Grin1 gene and 1.9 kb of the 5′-regulatory region. In the present study, we analysed the molecular mechanisms that regulate chicken Grin1 gene transcription in undifferentiated cells and neurons. By functional analysis of chicken Grin1...

...Giridhar Mudduluru; Heike Allgayer Axl is a receptor tyrosine kinase which promotes anti-apoptosis, mitogenesis, invasion, angiogenesis and metastasis, and is highly expressed in cancers. However, the transcriptional regulation of this important gene has never been characterized. The present study...

... residues of VSV P protein was shown to be required for transcription and not for replication (Das et al. 1997). A tripartite complex composed of transcriptionally inactive mutant of P, and wild type L and N protein efficiently synthesized 42 S replication product in vitro (Gupta et al. 2003). These studies...

... for the continued expression of some plasma membrane receptors. 20 5 1990 © 1990 Plenum Publishing Corporation 1990 neutrophils oxidants receptors transcription translation priming cytokines Abbreviations fMet-Leu-Phe, N-formylmethionyl-Leucyl-Phenylalanine; rGM-CSF, recombinant...

... further the involvement of the three promoter sequence elements using a cloned, transcriptionally active gene from which the natural TATA-box has been deleted and we also provide further evidence that the transcriptional app/tratus interacts differently with the promoter in vivo and in reconstituted...