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1-25 of 25
Keywords: type 2 diabetes
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Articles
Meriem Fassatoui, Azadeh Saffarian, Céline Mulet, Henda Jamoussi, Amel Gamoudi, Yosra Ben Halima, Meriem Hechmi, Sonia Abdelhak, Abdelmajid Abid, Philippe J. Sansonetti, Thierry Pedron, Rym Kefi
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (9): BSR20220803.
Published: 12 September 2023
... (T1D), 10 type 2 diabetic (T2D) patients and 13 healthy (H) subjects. Illumina Miseq technology was used to sequence V3-V4 hypervariable regions of bacterial 16SrRNA gene. Data were analyzed referring to QIIME 2 pipeline. RStudio software was used to explore the role of nutrition in gut bacterial...
Includes: Supplementary data
Articles
Prawej Ansari, Sara S. Islam, Samia Akther, Joyeeta T. Khan, Jaber A. Shihab, Yasser H. A. Abdel-Wahab
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (5): BSR20230329.
Published: 23 May 2023
... actions of EEAA. Thus, our finding suggests that EEAA, as a good source of antidiabetic constituents, would be beneficial for Type 2 diabetes patients. 22 02 2023 19 04 2023 27 04 2023 03 05 2023 The impact of EEAA on insulin glycation was examined as previously described [ 22...
Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (2): BSR20221430.
Published: 02 February 2023
...You Lv; Yuanyuan Zheng; Xue Zhao; Zhuo Li; Guixia Wang A cross-sectional study was performed using metabolomics in overweight patients with Type 2 diabetes (T2D) at different stages of the disease. We aimed to identify potential metabolites for assessing islet β-cell function in order...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (11): BSR20220461.
Published: 16 November 2022
...(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . alpha amylase free radicals medicinal plants type 2 diabetes Diabetes mellitus (DM...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (8): BSR20211060.
Published: 05 August 2021
... and type 2 diabetes (patients, n =16), were measured by a band-shift assay using a maleimide compound. Redox-IDX-apoE candidates were determined by calculating the values of these fractions and the total apoE concentration. Results: Cys number of apoE significantly increased for the ratio of roxi-apoE...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (5): BSR20210029.
Published: 14 May 2021
... metabolic syndromes obesity TACE type 2 diabetes There is increasing evidence showing the link between metabolic syndrome and cardiovascular disease, chronic kidney disease, stroke and diabetes [ 1 ]. The metabolic syndrome is defined as a cluster of independent risk factors which coexist...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203824.
Published: 22 January 2021
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. DPP-IV glucagon-like peptide-1 hyperglycaemia insulin Medicinal plants type 2 diabetes Diabetes Mellitus has become a worldwide concern, manifesting as one of the most major health issues within...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20200026.
Published: 20 August 2020
...Daniela Pirri; Maria Fragiadaki; Paul C. Evans Atherosclerosis is a major cause of mortality worldwide and is driven by multiple risk factors, including diabetes. Diabetes is associated with either an insulin deficiency in its juvenile form or with insulin resistance and obesity in Type 2 diabetes...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (10): BSR20190078.
Published: 21 October 2019
...Tae-Joon Park; Heun-Sik Lee; Young Jin Kim; Bong-Jo Kim Metabolome-genome wide association studies (mGWASs) are useful for understanding the genetic regulation of metabolites in complex diseases, including type 2 diabetes (T2D). Numerous genetic variants associated with T2D-related metabolites have...
Includes: Supplementary data
Articles
Rihua Zhang, Jing Bao Kan, Shan Lu, Pei Tong, Jie Yang, Ling Xi, Xiubing Liang, Dongming Su, Dong Li, Yun Liu
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (9): BSR20182042.
Published: 09 September 2019
[email protected] ) © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . 11β-HSD1 adipogenesis obesity S100A16 type 2 diabetes Obesity...
Includes: Supplementary data
Articles
Heinz Drexel, Andreas Leiherer, Christoph H. Saely, Eva Maria Brandtner, Kathrin Geiger, Alexander Vonbank, Peter Fraunberger, Axel Muendlein
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20190299.
Published: 07 August 2019
...Heinz Drexel; Andreas Leiherer; Christoph H. Saely; Eva Maria Brandtner; Kathrin Geiger; Alexander Vonbank; Peter Fraunberger; Axel Muendlein Inhibition of the sodium glucose co-transporter 2 (SGLT2) reduces cardiovascular morbidity, and mortality in patients with type 2 diabetes mellitus (T2DM...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20182172.
Published: 31 May 2019
...Ming Zhong; Yilong Wu; Weijie Ou; Linjing Huang; Liyong Yang Aims : To identify the key differentially expressed genes (DEGs) in islet and investigate their potential pathway in the molecular process of type 2 diabetes. Methods : Gene Expression Omnibus (GEO) datasets (GSE20966, GSE25724, GSE38642...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (2): BSR20170665.
Published: 15 February 2019
...Amanda C. Okolie; Oluwafemi E. Kale; Odutola Osilesi Recent studies have shown that Type 2 diabetes (T2D) in rats can result through a synergy that links obesity to insulin resistance and β-cell dysfunction. The present study achieved T2D via high fructose (20% w/v , p.o.), streptozotocin single...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181696.
Published: 28 November 2018
... polymorphisms of SelS and Type 2 diabetes (T2DM) remains unclear. Methods: In the present study, we genotyped four single nucleotide polymorphisms (rs12910524, rs1384565, rs2101171, rs4965814) of SelS gene using TaqMan genotyping method in a case–control study (1947 T2DM patients and 1639 control subjects...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20180660.
Published: 07 September 2018
... review summarizes available data on brain metabolite levels in patients with DM and DM-related comorbid complications, in order to identify non-invasive biomarkers for diabetes-induced brain metabolic changes during DM progression. DM is classified into type 1 diabetes (T1DM), type 2 diabetes...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20171284.
Published: 13 July 2018
... developed an animal model presenting both Alzheimer’s disease (AD) and type 2 diabetes (T2D), by crossing APP/PS1 mice (AD model) with streptozotocin (STZ)-treated mice (a T2D model). Neuronal apoptosis was detected by TUNEL staining and the expression levels of apoptosis-related proteins were examined...
Articles
Huajie Li, Jian Wu, Linfeng Zhu, Luolin Sha, Song Yang, Jiang Wei, Lei Ji, Xiaochun Tang, Keshi Mao, Liping Cao, Ning Wei, Wei Xie, Zhilong Yang
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (1): BSR20170862.
Published: 10 January 2018
...Huajie Li; Jian Wu; Linfeng Zhu; Luolin Sha; Song Yang; Jiang Wei; Lei Ji; Xiaochun Tang; Keshi Mao; Liping Cao; Ning Wei; Wei Xie; Zhilong Yang Insulin degrading enzyme (IDE) is believed to act as a junction point of Type 2 diabetes (T2D) and Alzheimer's disease (AD); however, the underlying...
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (4): BSR20171089.
Published: 31 August 2017
... metabolic syndrome obesity type 2 diabetes VEGF-B The worldwide pandemic of obesity associated with net positive energy balance, sedentary lifestyle and increased consumption of animal fats, processed food and sugar has brought to forefront the need for novel therapeutic strategies to protect...
Articles
Sohel Bin Azad, Prawej Ansari, Shofiul Azam, Saad Mosharraf Hossain, Mohammad Ibtida-Bin Shahid, Mahmudul Hasan, J.M.A. Hannan
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (3): BSR20170059.
Published: 30 June 2017
... to explore the possible mechanisms of action of M. oleifera extract through different methods. Primarily, we measured fasting blood glucose and performed glucose tolerance test, in Type 2 diabetic rats. Further, we studied the effects of extracts on pancreatic insulin concentration. Extracts’ effect...
Articles
Plasma miR-21 expression: an indicator for the severity of Type 2 diabetes with diabetic retinopathy
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (2): BSR20160589.
Published: 27 March 2017
...Qi Jiang; Xue-Man Lyu; Yi Yuan; Ling Wang To investigate the roles of plasma miR-21 in the pathogenic process of Type 2 diabetes (T2D) with diabetic retinopathy (DR). T2D patients included patients without DR (NDR) group, patients with non-proliferative/background DR (BDR) group and patients...
Articles
In Collection
Celebrating 100 years of insulin research
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (1): BSR20160514.
Published: 25 January 2017
...Rasmus Magnusson; Mika Gustafsson; Gunnar Cedersund; Peter Strålfors; Elin Nyman The molecular mechanisms of insulin resistance in Type 2 diabetes have been extensively studied in primary human adipocytes, and mathematical modelling has clarified the central role of attenuation of mammalian target...
Articles
Glaucia E. Callera, Tayze T. Antunes, Jose W. Correa, Danielle Moorman, Alexey Gutsol, Ying He, Aurelie Nguyen Dinh Cat, Ana M. Briones, Augusto C. Montezano, Kevin D. Burns, Rhian M. Touyz
Journal:
Bioscience Reports
Biosci Rep (2016) 36 (5): e00398.
Published: 27 October 2016
...) and creatinine (mg/ml). Results were expressed as albumin:creatinine ratio (ACR, μg/mg). albuminuria candesartan nephropathy RAS type 2 diabetes Total protein was extracted from kidney cortex and probed for AT2R, Mas, ACE2, ERK1/2, p38MAPK, JNK, plasminogen activator inhibitor-1 (PAI-1...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2012) 32 (2): 185–195.
Published: 21 November 2011
...Hui Huang; Hong Xin; Xinhua Liu; Yajun Xu; Danyi Wen; Yahua Zhang; Yi Zhun Zhu There are reports of early evidence that suggest the involvement of chronic low-grade inflammation in the pathogenesis of Type 2 diabetes. Thus, substances that have effects in reducing inflammation could be potential...
Articles
Ali Ben Djoudi Ouadda, Emile Levy, Ehud Ziv, Geneviève Lalonde, Alain T. Sané, Edgar Delvin, Mounib Elchebly
Journal:
Bioscience Reports
Biosci Rep (2009) 29 (5): 283–292.
Published: 15 June 2009
.... Nevertheless, its involvement in insulin resistance- and TD2 (Type 2 diabetes)-associated dyslipidaemia remains enigmatic. In the present study, we employed the Psammomys obesus gerbil, a well-established model of insulin resistance and TD2, in order to appreciate the contribution of the AMPK/ACC pathway...
Articles
Paulo J. Oliveira, Anabela P. Rolo, R. Seiça, Carlos M. Palmeira, M. S. Santos, António J. M. Moreno
Journal:
Bioscience Reports
Biosci Rep (2001) 21 (1): 45–53.
Published: 01 February 2001
...Paulo J. Oliveira; Anabela P. Rolo; R. Seiça; Carlos M. Palmeira; M. S. Santos; António J. M. Moreno Type 2 diabetes (or non-insulin dependent diabetes mellitus, NIDDM) is a common metabolic disease in man. The Goto–Kakizaki (GK) rat has been designed as a NIDDM model. Previous studies...
