... methanesulfonate (MitoDNP). TPP cations accumulate within mitochondria driven by the membrane potential (Δ ψ ), the predominant component of Δ p . Our hypothesis was that MitoDNP would accumulate in mitochondria at high Δ ψ where it would act as a protonophore, but that at lower Δ ψ the accumulation and uncoupling...

...Elena V. Schmalhausen; Vladimir I. Muronetz Data on alterations of the properties of glyceraldehyde-3-phosphate dehydrogenase upon oxidation of its functional groups are reviewed; a mechanism of uncoupling of oxidation and phosphorylation in glycolysis is considered. Possible ways of regulating...

...A. A. Starkov Recently, it was proposed that the thyroid hormone-mediated uncoupling in mitochondria is involved in the cellular defence system against free radicals (Skulachev V.P. (1996) Quart. Rev. Biophys. 29: 169–202). This phenomenon was named “mild” uncoupling. It was postulated...

.... © 1997 Plenum Publishing Corporation 1997 Reactive oxygen species mitochondria pore apoptosis uncoupling non-coupled respiration aconitase Bioscience Reports, Vol. 17, No. 3, 1997 REVIEW Membrane-Linked Systems Preventing Superoxide Formation Vladimir P. Skulachev Received January 17...

...S. Luvisetto During the past years many efforts have been made to elucidate the origin of the uncoupling mechanisms induced by hyperthyroidism in mitochondria. Two main mechanisms have been proposed: a classical protonophoric uncoupler mechanism, considering the action of thyroid hormones...