... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cardiac hypertrophy and remodeling Cyclophilin A Inflammation Matrix metalloproteinases Oxidative stress Vascular injury Cardiac hypertrophy and remodeling...

... overexpression. Moreover, siRNA-mediated HDGF gene silencing significantly suppressed constitutive expression of IL-6, but not TNF-α, in SMCs. These findings support the role of HDGF in maintaining vascular expression of IL-6, which has been regarded a crucial regenerative factor for acute vascular injury...

... vascular injury The adaptive response of the vascular wall to mechanical injury determines the outcome of endovascular interventions. This response is characterized by vascular smooth muscle cells (VSMC) apoptosis [ 1 – 3 ], inflammation [ 4 ] and cell proliferation [ 3 , 5 ] that when unbalanced may...