Fifteen common polymorphic variants at six loci (apolipoproteins AI, B, CIII and E, hepatic lipase and lipoprotein lipase) involved in plasma lipid transport have been studied in 210 northern Spanish men, of whom 98 had proven coronary artery disease. The other 112 men were clinically free from coronary artery disease and acted as controls. The genotypes were investigated for relationships with plasma lipid and lipoprotein levels, as well as for the presence of coronary artery disease. As expected, the mean levels of plasma triacylglycerols (triglycerides) and lipoprotein (a) and the number of smokers were significantly higher in the disease group, and high-density lipoprotein (HDL)-cholesterol was significantly lower. Surprisingly, plasma cholesterol and low-density lipoprotein cholesterol were not different between the two groups. With regard to the common mutations, plasma triacylglycerol levels were related to the HindIII variants of lipoprotein lipase (P < 0.05), to the apolipoprotein CIII variant (C3175G in exon 4) and to the apolipoprotein AI XmnI polymorphisms (P < 0.05 and P < 0.02 respectively). The apolipoprotein E variants were related to plasma cholesterol (P < 0.05), HDL-cholesterol (P < 0.02), plasma triacylglycerols (P < 0.05) and the triacylglycerol/HDL ratio (P < 0.01). Only the three-codon insertion/deletion variants of the apolipoprotein B signal peptide region discriminated between the two groups with or without arterial disease (P = 0.02). The possible functional effects of these common mutations are discussed.
Skip Nav Destination
Article navigation
Research Article|
January 02 2001
Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease
Ll. MASANA;
Ll. MASANA
*Servei de Medicina Interna de Reus C, St. Llorenc s/n 43201, Reus, Spain
Search for other works by this author on:
G. FEBRER;
G. FEBRER
*Servei de Medicina Interna de Reus C, St. Llorenc s/n 43201, Reus, Spain
Search for other works by this author on:
J. CAVANNA;
J. CAVANNA
†Departments of Human Metabolism and Genetics, St. Bartholomew's Hospital, London EC1A 7BE, U.K.
Search for other works by this author on:
M. G. BARONI;
M. G. BARONI
‡Center of Internal Medicine and Biological Chemistry, La Sapienza University, Rome, Italy
Search for other works by this author on:
W. MARZ;
W. MARZ
§Clinical Chemistry, Albert Ludwigs Universitat, Freiburg, Germany
Search for other works by this author on:
M. M. HOFFMANN;
M. M. HOFFMANN
§Clinical Chemistry, Albert Ludwigs Universitat, Freiburg, Germany
Search for other works by this author on:
B. SHINE;
B. SHINE
†Departments of Human Metabolism and Genetics, St. Bartholomew's Hospital, London EC1A 7BE, U.K.
Search for other works by this author on:
D. J. GALTON
†Departments of Human Metabolism and Genetics, St. Bartholomew's Hospital, London EC1A 7BE, U.K.
Correspondence: Professor D. Galton (e-mail [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
March 20 2000
Revision Received:
August 15 2000
Accepted:
September 25 2000
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2001
2001
Clin Sci (Lond) (2001) 100 (2): 183–190.
Article history
Received:
March 20 2000
Revision Received:
August 15 2000
Accepted:
September 25 2000
Citation
Ll. MASANA, G. FEBRER, J. CAVANNA, M. G. BARONI, W. MARZ, M. M. HOFFMANN, B. SHINE, D. J. GALTON; Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease. Clin Sci (Lond) 1 February 2001; 100 (2): 183–190. doi: https://doi.org/10.1042/cs1000183
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.