Results from several recent reports have linked high serum C-reactive protein (CRP) levels to atherosclerotic disease and its complications. The aims of the present study were to investigate the relationship between CRP levels and subclinical atherosclerosis, as measured by ultrasound in the carotid and femoral arteries; and also to examine whether CRP levels are associated with antibodies to oxidized low-density lipoprotein (Ox-LDL). The study group (n = 391) consisted of clinically healthy 58-year-old men recruited from the general population. CRP and antibody titres to Ox-LDL were measured by ELISA. The results showed an association between CRP and ultrasound-assessed subclinical atherosclerosis in the femoral artery (r = 0.14, P = 0.010), and also between CRP and systolic blood pressure, diastolic blood pressure, heart rate, triglycerides, high-density lipoprotein, body mass index, waist-to-hip ratio (WHR), blood glucose, cigarette-years and antibody titres to ox-LDL (r = 0.19, P < 0.001). In this clinically healthy population of 58-year-old men, CRP levels were associated with both intima-media thickness and plaque occurrence in the femoral artery. The association between CRP and femoral atherosclerosis was not independent of smoking, serum LDL cholesterol, or systolic blood pressure. CRP levels were independently related to abdominal obesity measured as WHR, smoking and antibody titres to Ox-LDL.
Skip Nav Destination
Article navigation
April 2001
Research Article|
February 26 2001
Relationship between C-reactive protein and intima-media thickness in the carotid and femoral arteries and to antibodies against oxidized low-density lipoprotein in healthy men: the Atherosclerosis and Insulin Resistance (AIR) study
Johannes HULTHE
;
*Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, 413 45 Gothenburg, Sweden
Correspondence: Dr Johannes Hulthe (e-mail johannes.hulthe@wlab.wall.gu.se).
Search for other works by this author on:
John WIKSTRAND
;
John WIKSTRAND
*Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, 413 45 Gothenburg, Sweden
Search for other works by this author on:
Björn FAGERBERG
Björn FAGERBERG
†Department of Medicine, Sahlgrenska University Hospital, Göteborg University, 413 45 Gothenburg, Sweden
Search for other works by this author on:
Clin Sci (Lond) (2001) 100 (4): 371–378.
Article history
Received:
October 02 2000
Revision Received:
November 22 2000
Accepted:
December 22 2000
Citation
Johannes HULTHE, John WIKSTRAND, Björn FAGERBERG; Relationship between C-reactive protein and intima-media thickness in the carotid and femoral arteries and to antibodies against oxidized low-density lipoprotein in healthy men: the Atherosclerosis and Insulin Resistance (AIR) study. Clin Sci (Lond) 1 April 2001; 100 (4): 371–378. doi: https://doi.org/10.1042/cs1000371
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
10
Views
0
Citations
Cited By
Related Articles
Identification of oxidized low-density lipoprotein in human serum by NMR spectroscopy
Clin Sci (Lond) (October,1998)
Circulating oxidized low-density lipoprotein is increased in hypertension
Clin Sci (Lond) (November,2003)
C-reactive protein for predicting all-cause mortality in patients with acute ischemic stroke: a meta-analysis
Biosci Rep (February,2019)
Acute-phase protein response is impaired in severely malnourished children
Clin Sci (Lond) (February,1993)