Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating blood pressure and cardiovascular homoeostasis. The actions of Ang II are mediated by at least two receptor subtypes, designated AT1 and AT2. In addition, other angiotensin receptors have been identified which may recognize other angiotensin peptide fragments; however, until now only the AT1 and AT2 receptor have been cloned in animals or humans. Most of the well-described actions of Ang II, such as vasoconstriction, facilitation of sympathetic transmission, stimulation of aldosterone release and promotion of cellular growth are all mediated by the AT1 receptor. Much less is known about the function of the AT2 receptor, but recent studies suggest that it may play a role in mediating anti-proliferation, cellular differentiation, apoptosis and vasodilatation. In this review, we discuss recent advances in our understanding of Ang II receptors, in particular, their distribution, signalling and function.
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Review Article| March 27 2001
Angiotensin receptors: distribution, signalling and function
Diem T. DINH;
Albert G. FRAUMAN;
Colin I. JOHNSTON;
Maurice E. FABIANI
*Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Austin Campus, Studley Road, Heidelberg, VIC 3084, Australia
Correspondence: Dr Maurice E. Fabiani (e-mail firstname.lastname@example.org).
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Clin Sci (Lond) (2001) 100 (5): 481–492.
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Diem T. DINH, Albert G. FRAUMAN, Colin I. JOHNSTON, Maurice E. FABIANI; Angiotensin receptors: distribution, signalling and function. Clin Sci (Lond) 1 May 2001; 100 (5): 481–492. doi: https://doi.org/10.1042/cs1000481
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