Moderate exercise reduces postprandial triacylglycerol concentrations, which are a risk marker for coronary heart disease. The present study sought to determine the qualitative nature of exercise-induced changes in lipid metabolism and their association (if any) with changes in factor VII activation. Eleven normotriglyceridaemic men, aged 51.7±6.1 years (mean±S.D.), participated in two oral fat tolerance tests after different pre-conditions: control (no exercise), and exercise (90 min of brisk walking the day before). Venous blood samples were obtained in the fasted state and for 8 h after ingestion of a high-fat meal (1.32 g of fat, 1.36 g of carbohydrate, 0.30 g of protein and 10 mg of [1,1,1-13C] tripalmitin·kg-1 body mass). Prior exercise reduced postprandial plasma triacylglycerol concentrations by 25±3% (mean±S.E.M.), with lower concentrations in the Svedberg flotation rate (Sf) 20–400 (very-low-density lipoprotein) fraction accounting for 79±10% of this reduction. There was no effect on plasma factor VII coagulant activity or on the concentration of the active form of factor VIIa. Prior exercise increased postprandial serum 3-hydroxybutyrate and plasma fatty acid concentrations, decreased serum postprandial insulin concentrations and increased exogenous (8 h 13C breath excretion of 15.1±0.9% of ingested dose compared with 11.9±0.8%; P = 0.00001) and endogenous postprandial fat oxidation. These data raise the possibility that reduced hepatic secretion of very-low-density lipoprotein plays a role in the attenuation of plasma triacylglycerol concentrations seen after exercise, although it is possible that increased triacylglycerol clearance also contributes to this effect.
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April 03 2001
Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity
Jason M. R. GILL;
*Human Muscle Metabolism Research Group, Loughborough University, Loughborough, LE11 3TU, U.K.
Correspondence: Dr Jason M. R. Gill, Department of Pathological Biochemistry, 4th Floor, Queen Elizabeth Building, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, U.K. (e-mail [email protected]).
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Keith N. FRAYN;
Keith N. FRAYN
†Oxford Lipid Metabolism Group, Radcliffe Infirmary, Oxford, OX2 6HE, U.K.
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Stephen A. WOOTTON;
Stephen A. WOOTTON
‡Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, U.K.
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George J. MILLER;
George J. MILLER
§MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, Medical College of St Bartholomew's Hospital, London EC1M 6BQ, U.K.
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Adrianne E. HARDMAN
Adrianne E. HARDMAN
*Human Muscle Metabolism Research Group, Loughborough University, Loughborough, LE11 3TU, U.K.
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Publisher: Portland Press Ltd
Received:
September 21 2000
Revision Received:
December 01 2000
Accepted:
February 07 2001
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2001
2001
Clin Sci (Lond) (2001) 100 (5): 517–527.
Article history
Received:
September 21 2000
Revision Received:
December 01 2000
Accepted:
February 07 2001
Citation
Jason M. R. GILL, Keith N. FRAYN, Stephen A. WOOTTON, George J. MILLER, Adrianne E. HARDMAN; Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity. Clin Sci (Lond) 1 May 2001; 100 (5): 517–527. doi: https://doi.org/10.1042/cs1000517
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