Full-field visual evoked potentials and visual information processing were measured in 16 normal, healthy subjects during a hyperinsulinaemic clamp. A randomized cross-over design was used across three conditions: hypoglycaemia and caffeine; hypoglycaemia and placebo; and euglycaemia and caffeine. The latency of the P100 component of the pattern-reversal visual evoked potential increased significantly from rest to hypoglycaemia, but no effect of caffeine was found. Subjects were subsequently divided into two median groups based on the increase in P100 latency in the placebo condition (Group 1, +0.5 ms; Group 2, +5.6 ms). In the absence of caffeine, an inverse correlation between the increase in P100 latency from rest and a deterioration in visual movement detection was found for Group 2, but not for Group 1. Caffeine ingestion resulted in a further increase in P100 latency, from rest to hypoglycaemia, for subjects in Group 2. Hypoglycaemia in the absence of caffeine produces changes in visual sensation from rest to hypoglycaemia. In those subjects most sensitive to the effects of hypoglycaemia (Group 2), the increase in P100 latency was associated with poorer performance in tests of visual information processing. Caffeine ingestion produced further increases in P100 latency in these subjects.
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June 2001
Research Article|
May 08 2001
Influence of hypoglycaemia, with or without caffeine ingestion, on visual sensation and performance
G. OWEN;
G. OWEN
*Centre for Human Sciences, Defence Evaluation and Research Agency, Farnborough, Hampshire GU14 0LX, U.K.
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J. WATSON;
J. WATSON
†Bournemouth Diabetes and Endocrinology Centre, Royal Bournemouth Hospitals, Bournemouth, Dorset BH7 7DW, U.K.
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A. MCGOWN;
A. MCGOWN
*Centre for Human Sciences, Defence Evaluation and Research Agency, Farnborough, Hampshire GU14 0LX, U.K.
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S. SHARMA;
S. SHARMA
*Centre for Human Sciences, Defence Evaluation and Research Agency, Farnborough, Hampshire GU14 0LX, U.K.
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I. DEARY;
I. DEARY
‡Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, U.K.
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D. KERR;
D. KERR
†Bournemouth Diabetes and Endocrinology Centre, Royal Bournemouth Hospitals, Bournemouth, Dorset BH7 7DW, U.K.
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G. BARRETT
G. BARRETT
*Centre for Human Sciences, Defence Evaluation and Research Agency, Farnborough, Hampshire GU14 0LX, U.K.
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Clin Sci (Lond) (2001) 100 (6): 619–626.
Article history
Received:
December 18 2000
Accepted:
March 02 2001
Citation
G. OWEN, J. WATSON, A. MCGOWN, S. SHARMA, I. DEARY, D. KERR, G. BARRETT; Influence of hypoglycaemia, with or without caffeine ingestion, on visual sensation and performance. Clin Sci (Lond) 1 June 2001; 100 (6): 619–626. doi: https://doi.org/10.1042/cs1000619
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