Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal injury. Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice. We therefore examined whether spray-dried, defatted colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons. Healthy male volunteers (n = 7) participated in a randomized crossover trial comparing changes in gut permeability (lactulose/rhamnose ratios) before and after 5 days of 50 mg of indomethacin three times daily (tds) per oral with colostrum (125 ml, tds) or whey protein (control) co-administration. A second study examined the effect of colostral and control solutions (125 ml, tds for 7 days) on gut permeability in patients (n = 15) taking a substantial, regular dose of an NSAID for clinical reasons. For both studies, there was a 2 week washout period between treatment arms. In volunteers, indomethacin caused a 3-fold increase in gut permeability in the control arm (lactulose/rhamnose ratio 0.36±0.07 prior to indomethacin and 1.17±0.25 on day 5, P < 0.01), whereas no significant increase in permeability was seen when colostrum was co-administered. In patients taking long-term NSAID treatment, initial permeability ratios were low (0.13±0.02), despite continuing on the drug, and permeability was not influenced by co-administration of test solutions. These studies provide preliminary evidence that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans.
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June 2001
Research Article|
May 03 2001
Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability
Raymond J. PLAYFORD
;
Raymond J. PLAYFORD
*Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K.
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Christopher E. MACDONALD
;
Christopher E. MACDONALD
†Department of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, U.K.
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Denis P. CALNAN
;
Denis P. CALNAN
†Department of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, U.K.
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David N. FLOYD
;
David N. FLOYD
†Department of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, U.K.
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Theo PODAS
;
Theo PODAS
†Department of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, U.K.
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Wendy JOHNSON
;
Wendy JOHNSON
‡SHS International Ltd., 100 Wavertree Boulevard, Liverpool L7 9PT, U.K.
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Anthony C. WICKS
;
Anthony C. WICKS
†Department of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, U.K.
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O. BASHIR
;
O. BASHIR
*Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K.
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Tania MARCHBANK
Tania MARCHBANK
*Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K.
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Clin Sci (Lond) (2001) 100 (6): 627–633.
Article history
Received:
January 10 2001
Accepted:
March 09 2001
Citation
Raymond J. PLAYFORD, Christopher E. MACDONALD, Denis P. CALNAN, David N. FLOYD, Theo PODAS, Wendy JOHNSON, Anthony C. WICKS, O. BASHIR, Tania MARCHBANK; Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond) 1 June 2001; 100 (6): 627–633. doi: https://doi.org/10.1042/cs1000627
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