The purpose of this study was to quantify the extent to which skin blood flow (SBF) responses to application of endothelium-dependent and -independent vasodilating agents differ between Type I diabetic patients and healthy subjects. Patients and matched controls were studied after an overnight fast. SBF was determined with laser Doppler perfusion imaging before and after iontophoresis of acetylcholine (Ach; endothelium-dependent) and sodium nitroprusside (SNP; endothelium-independent). Basal SBF did not differ significantly between groups. Iontophoresis of ACh and SNP increased SBF 20-fold in controls. In the patients, the increases in SBF following iontophoresis of ACh and SNP were reduced by 18% and 19%, respectively, versus controls (P < 0.05 for both). These data demonstrate that Type I diabetic patients have similar diminished SBF responses to iontophoresis of ACh and SNP, which suggests that non-endothelial-dependent factors are primarily responsible for the diminished SBF responses.
Skip Nav Destination
Article navigation
Research Article|
May 24 2001
Diminished skin blood flow in Type I diabetes: evidence for non-endothelium-dependent dysfunction
Abram KATZ;
Abram KATZ
*Department of Surgical Sciences, Division of Clinical Physiology, Karolinska Institute, Karolinska Hospital, 171 76 Stockholm, Sweden
†Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden
Search for other works by this author on:
Karin EKBERG;
Karin EKBERG
*Department of Surgical Sciences, Division of Clinical Physiology, Karolinska Institute, Karolinska Hospital, 171 76 Stockholm, Sweden
Search for other works by this author on:
Bo-Lennart JOHANSSON;
Bo-Lennart JOHANSSON
*Department of Surgical Sciences, Division of Clinical Physiology, Karolinska Institute, Karolinska Hospital, 171 76 Stockholm, Sweden
Search for other works by this author on:
John WAHREN
John WAHREN
*Department of Surgical Sciences, Division of Clinical Physiology, Karolinska Institute, Karolinska Hospital, 171 76 Stockholm, Sweden
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
January 02 2001
Revision Received:
March 12 2001
Accepted:
April 03 2001
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2001
2001
Clin Sci (Lond) (2001) 101 (1): 59–64.
Article history
Received:
January 02 2001
Revision Received:
March 12 2001
Accepted:
April 03 2001
Citation
Abram KATZ, Karin EKBERG, Bo-Lennart JOHANSSON, John WAHREN; Diminished skin blood flow in Type I diabetes: evidence for non-endothelium-dependent dysfunction. Clin Sci (Lond) 1 July 2001; 101 (1): 59–64. doi: https://doi.org/10.1042/cs1010059
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |