Using both cross-sectional and longitudinal methods, we investigated the relationship between post-load serum glucose concentration in a 75 g oral glucose tolerance test (OGTT) and overall glycaemic state in subjects with impaired glucose tolerance (IGT). Glycaemic state was assessed by measuring glycated haemoglobin (HbA1c) and the serum concentration of 1,5-anhydroglucitol (1,5-AG). In the cross-sectional study, the concentration of 1,5-AG, while remaining within a normal range, was reduced to a degree proportional to the post-load glycaemic level. Although the correlation between HbA1c and post-load plasma glucose was relatively weak (r = 0.281, P < 0.001), a significant inverse correlation (r =-0.824, P < 0.0001) was found between 1,5-AG and mean post-load plasma glucose concentration in 211 subjects with IGT. Fasting plasma glucose (r =-0.539, P < 0.0001) and 2 h plasma glucose (r =-0.621, P < 0.0001) were correlated with 1,5-AG less strongly than was post-load glycaemia. Both 1,5-AG and HbA1c were correlated weakly but significantly with the fasting insulin concentration. In the longitudinal study we measured 1,5-AG and mean post-load plasma glucose with an OGTT once yearly for 10 years in 15 subjects with IGT. Strong inverse correlations were seen between 1,5-AG and mean post-load plasma glucose in each subject (range of r values among subjects of -0.584 to -0.978). These findings suggest a close relationship between post-load plasma glucose concentration measured by OGTT and overall glycaemic state in subjects with IGT.
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August 03 2001
Post-load glucose measurements in oral glucose tolerance tests correlate well with 1,5-anhydroglucitol, an indicator of overall glycaemic state, in subjects with impaired glucose tolerance
Toshikazu YAMANOUCHI;
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
Correspondence: Dr Toshikazu Yamanouchi (e-mail: [email protected]).
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Tae INOUE;
Tae INOUE
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
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Eri OGATA;
Eri OGATA
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
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Akiko KASHIWABARA;
Akiko KASHIWABARA
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
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Nobuyuki OGATA;
Nobuyuki OGATA
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
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Nori SEKINO;
Nori SEKINO
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
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Tomoe YOSHIMURA;
Tomoe YOSHIMURA
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
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Kaoru ICHIYANAGI;
Kaoru ICHIYANAGI
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
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Takahiro KAWASAKI
Takahiro KAWASAKI
1Department of Internal Medicine, University of Teikyo, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan
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Publisher: Portland Press Ltd
Received:
December 01 2000
Revision Received:
April 02 2001
Accepted:
May 03 2001
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2001
2001
Clin Sci (Lond) (2001) 101 (3): 227–233.
Article history
Received:
December 01 2000
Revision Received:
April 02 2001
Accepted:
May 03 2001
Citation
Toshikazu YAMANOUCHI, Tae INOUE, Eri OGATA, Akiko KASHIWABARA, Nobuyuki OGATA, Nori SEKINO, Tomoe YOSHIMURA, Kaoru ICHIYANAGI, Takahiro KAWASAKI; Post-load glucose measurements in oral glucose tolerance tests correlate well with 1,5-anhydroglucitol, an indicator of overall glycaemic state, in subjects with impaired glucose tolerance. Clin Sci (Lond) 1 September 2001; 101 (3): 227–233. doi: https://doi.org/10.1042/cs1010227
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