Oxidant generation during regular physical exercise training may influence the adaptive responses that have been shown to confer protection against oxidative stress induced by subsequent acute exercise. To examine this, we randomly assigned 32 males to either a normoxic (n = 14) or a hypoxic (n = 18) group. During the acute phase, subjects in the hypoxic group performed two maximal cycling tests in a randomized double-blind fashion: one under conditions of normoxia and the other under hypoxic conditions (inspired fraction of O2 = 0.21 and 0.16 respectively). During the intermittent phase, the normoxic and hypoxic groups each trained for 4 weeks at the same relative exercise intensity, under conditions of normoxia and hypoxia respectively. During acute exercise under hypoxic conditions, the venous concentrations of lipid hydroperoxides and malondialdehyde were increased, despite a comparatively lower maximal oxygen uptake (o2max) (P < 0.05 compared with normoxia). The increases in lipid hydroperoxides and malondialdehyde were correlated with the exercise-induced decrease in arterial haemoglobin oxygen saturation (r =-0.61 and r =-0.50 respectively; P < 0.05), but not with o2max. Intermittent hypoxic training attenuated the increases in lipid hydroperoxides and malondialdehyde induced by acute normoxic exercise more effectively than did normoxic training, due to a selective mobilization of α-tocopherol (P < 0.05). The latter was related to enhanced exercise-induced mobilization/oxidation of blood lipids due to a selective increase in o2max (P < 0.05 compared with normoxic group). We conclude that lipid peroxidation induced by acute exercise (1) increases during hypoxia; (2) is not regulated exclusively by a mass action effect of o2; and (3) is selectively attenuated by regular hypoxic training. Oxidative stress may thus be considered as a biological prerequisite for adaptation to physical stress in humans.
Skip Nav Destination
Article navigation
Research Article|
September 21 2001
Intermittent hypoxic training: implications for lipid peroxidation induced by acute normoxic exercise in active men
Damian M. BAILEY;
*Hypoxia Research Unit, Health and Exercise Sciences Research Laboratory, School of Applied Sciences, University of Glamorgan, Pontypridd CF37 1DL, South Wales, U.K.
Correspondence: Dr Damian M. Bailey (e-mail [email protected]).
Search for other works by this author on:
Bruce DAVIES;
Bruce DAVIES
*Hypoxia Research Unit, Health and Exercise Sciences Research Laboratory, School of Applied Sciences, University of Glamorgan, Pontypridd CF37 1DL, South Wales, U.K.
Search for other works by this author on:
Ian S. YOUNG
Ian S. YOUNG
†Institute of Clinical Science, Queen's University, Belfast BT12 6BJ, N. Ireland, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
February 26 2001
Revision Received:
May 01 2001
Accepted:
June 28 2001
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2001
2001
Clin Sci (Lond) (2001) 101 (5): 465–475.
Article history
Received:
February 26 2001
Revision Received:
May 01 2001
Accepted:
June 28 2001
Citation
Damian M. BAILEY, Bruce DAVIES, Ian S. YOUNG; Intermittent hypoxic training: implications for lipid peroxidation induced by acute normoxic exercise in active men. Clin Sci (Lond) 1 November 2001; 101 (5): 465–475. doi: https://doi.org/10.1042/cs1010465
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |