The objective of the present study was to investigate the validity of using holmium as a faecal marker in a copper absorption study using a highly enriched 65Cu stable isotope label. Ten volunteers (nine female, one male) aged 24-55 years were recruited from the Norwich area to take part in a free-living study. The study was conducted in the Human Nutrition Unit at the Institute of Food Research, Norwich, U.K., and involved feeding breakfast test meals containing foods labelled intrinsically or extrinsically with a highly enriched 65Cu stable isotope label. A 1mg oral dose of the rare earth element holmium was administered to volunteers simultaneously with an oral dose of highly enriched 65Cu stable isotope as a label in the breakfast test meal. Complete faecal collections were made for 10 days after dosing, and the mean percentage holmium recovery (±S.D.) was 105±15%. After correcting for re-excreted copper label, the labelled copper and holmium had similar excretory profiles. It was concluded that holmium is a valid faecal marker in adult human copper absorption studies using stable isotopes.
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Research Article|
January 14 2002
Holmium as a faecal marker for copper absorption studies in adults
Linda J. HARVEY;
*Nutrition and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, U.K.
Correspondence: Dr Linda Harvey (e-mail [email protected]).
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Gosia MAJSAK-NEWMAN;
Gosia MAJSAK-NEWMAN
*Nutrition and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, U.K.
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Jack R. DAINTY;
Jack R. DAINTY
*Nutrition and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, U.K.
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S. Gabrielle WHARF;
S. Gabrielle WHARF
*Nutrition and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, U.K.
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Martin D. REID;
Martin D. REID
†The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB2 9SB, U.K.
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John H. BEATTIE;
John H. BEATTIE
†The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB2 9SB, U.K.
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Susan J. FAIRWEATHER-TAIT
Susan J. FAIRWEATHER-TAIT
*Nutrition and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, U.K.
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Publisher: Portland Press Ltd
Received:
April 24 2001
Revision Received:
August 28 2001
Accepted:
October 08 2001
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2002
2002
Clin Sci (Lond) (2002) 102 (2): 233–240.
Article history
Received:
April 24 2001
Revision Received:
August 28 2001
Accepted:
October 08 2001
Citation
Linda J. HARVEY, Gosia MAJSAK-NEWMAN, Jack R. DAINTY, S. Gabrielle WHARF, Martin D. REID, John H. BEATTIE, Susan J. FAIRWEATHER-TAIT; Holmium as a faecal marker for copper absorption studies in adults. Clin Sci (Lond) 1 February 2002; 102 (2): 233–240. doi: https://doi.org/10.1042/cs1020233
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