Electrolysis is a method of tissue ablation that creates chemical species and a pH gradient in response to direct current. Initial studies of electrolysis in animal models and humans have shown that it is a safe, predictable and effective process for destroying normal and tumour-bearing liver in a linear, dose-dependent manner. Presently, the amount of current that is applied (in coulombs) has to be calculated using historical data, with inherent inaccuracy. The present study tested whether pH could be used as a real-time monitor in order to predict more accurately the extent of necrosis. A total of 70 electrolytic lesions were created in 14 pigs, with pH monitoring of the lesion edge. The normal range of pH values was 6.5-8.7. A pH of less than 6 (at the anode) or more than 9 (at the cathode) reflected total cellular necrosis. When a pH value was recorded between 6.0 and 6.5 at the anode or between 8.7 and 9.0 at the cathode, the presence of necrosis was variable. In conclusion, during electrolytic ablation, pH measurement can monitor the extent of the induced necrosis.
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Research Article|
March 04 2002
Liver electrolysis: pH can reliably monitor the extent of hepatic ablation in pigs
J. Guy FINCH;
J. Guy FINCH
*University of Adelaide Department of Surgery, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
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Beverley FOSH;
Beverley FOSH
*University of Adelaide Department of Surgery, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
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Adrian ANTHONY;
Adrian ANTHONY
*University of Adelaide Department of Surgery, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
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Eric SLIMANI;
Eric SLIMANI
*University of Adelaide Department of Surgery, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
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Michael TEXLER;
Michael TEXLER
†Department of Pathology, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
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David P. BERRY;
David P. BERRY
‡Department of Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE2 7LX, U.K.
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Ashley R. DENNISON;
Ashley R. DENNISON
‡Department of Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE2 7LX, U.K.
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Guy J. MADDERN
*University of Adelaide Department of Surgery, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
Correspondence: Professor G. J. Maddern (e-mail [email protected]).
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Publisher: Portland Press Ltd
Received:
July 13 2001
Revision Received:
November 06 2001
Accepted:
December 08 2001
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2002
2002
Clin Sci (Lond) (2002) 102 (4): 389–395.
Article history
Received:
July 13 2001
Revision Received:
November 06 2001
Accepted:
December 08 2001
Citation
J. Guy FINCH, Beverley FOSH, Adrian ANTHONY, Eric SLIMANI, Michael TEXLER, David P. BERRY, Ashley R. DENNISON, Guy J. MADDERN; Liver electrolysis: pH can reliably monitor the extent of hepatic ablation in pigs. Clin Sci (Lond) 1 April 2002; 102 (4): 389–395. doi: https://doi.org/10.1042/cs1020389
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