We investigated whether the capacity for repetitive submaximal muscle contraction was reduced in a group of subjects (n = 8) with a primary deficiency of myoadenylate deaminase (MAD). Quadriceps femoris muscle fatigue was evaluated using voluntary and electrically stimulated contractions during 20min of repetitive voluntary isometric contractions at 40% of maximal force-generating capacity (MFGC). After 5min of exercise, MFGC had declined significantly to 70.6±4.1% (mean±S.E.M.) and 87.2±1.6% of baseline values in MAD-deficient and sedentary control subjects (n = 8) respectively (P = 0.002 between groups). After 5min of exercise, the half-relaxation time had increased significantly to 113.4±6.1% of basline in MAD-deficient muscle, but had decreased significantly to 94.1±1.3% in control subjects (P = 0.003 between groups). All control subjects completed the 20-min exercise test. Five of the MAD-deficient subjects had to stop exercising due to early muscle fatigue; however, three of the MAD-deficient subjects were able to complete the 20-min exercise test. In conclusion, although the capacity for repetitive submaximal isometric muscle contractions for the group of MAD-deficient subjects was significantly decreased, it remains uncertain whether MAD deficiency is the sole cause of pronounced muscle fatigue.
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Research Article|
April 18 2002
Muscle function during repetitive moderate-intensity muscle contractions in myoadenylate deaminase-deficient Dutch subjects
C.J. DE RUITER;
*Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
Correspondence: Dr C.J. de Ruiter (e-mail C_J_de_Ruiter@fbw.vu.nl).
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A.M. MAY;
A.M. MAY
*Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
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B.G.M. VAN ENGELEN;
B.G.M. VAN ENGELEN
†Institute for Fundamental and Clinical Human Movement Sciences, Department of Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
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R.A. WEVERS;
R.A. WEVERS
†Institute for Fundamental and Clinical Human Movement Sciences, Department of Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
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G.C. STEENBERGEN-SPANJERS;
G.C. STEENBERGEN-SPANJERS
†Institute for Fundamental and Clinical Human Movement Sciences, Department of Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
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A. DE HAAN
A. DE HAAN
*Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
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Publisher: Portland Press Ltd
Accepted:
January 31 2001
Received:
June 11 2001
Revision Received:
November 22 2001
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2002
2002
Clin Sci (Lond) (2002) 102 (5): 531–539.
Article history
Accepted:
January 31 2001
Received:
June 11 2001
Revision Received:
November 22 2001
Citation
C.J. DE RUITER, A.M. MAY, B.G.M. VAN ENGELEN, R.A. WEVERS, G.C. STEENBERGEN-SPANJERS, A. DE HAAN; Muscle function during repetitive moderate-intensity muscle contractions in myoadenylate deaminase-deficient Dutch subjects. Clin Sci (Lond) 1 May 2002; 102 (5): 531–539. doi: https://doi.org/10.1042/cs1020531
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