There is a lack of data on circulating levels of cell-adhesion molecules in relation to subclinical atherosclerosis measured in both the carotid and femoral arteries in humans. The aim of the present study was to investigate the relationship between clinically silent atherosclerosis and cell-adhesion molecules, and to explore the relationship between these molecules, C-reactive protein and the inflammatory cytokines interleukin-6, tumour necrosis factor-α (TNF-α), soluble TNF-α receptor p55 and soluble TNF-α receptor p75. The study group (n = 391) consisted of clinically healthy 58-year-old men recruited from the general population. The results showed a positive trend between levels of soluble intercellular cell-adhesion molecule 1 (sICAM-1) and plaque occurrence in the carotid and femoral arteries (P = 0.008), and also a univariate correlation between sICAM-1 levels and the composite variable of carotid and femoral intima-media thickness (P<0.001). When adjusted for other risk factors, the relationship between sICAM-1 and intima-media thickness no longer reached statistical significance. The level of sICAM-1 was associated with those of the pro-inflammatory cytokine TNF-α, its two soluble receptors, and also interleukin-6 and C-reactive protein. Levels of soluble E-selectin and vascular cell-adhesion molecule 1 (VCAM-1) showed weak or no association with subclinical atherosclerosis and inflammatory variables. Thus, in clinically healthy middle-aged men, levels of sICAM-1, but not of soluble VCAM-1 or E-selectin, were associated with both subclinical atherosclerosis and inflammatory variables.
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June 28 2002
Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (AIR) study
Johannes HULTHE;
1The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, S-413 45 Gothenburg, Sweden
Correspondence: Dr Johannes Hulthe (e-mail [email protected]).
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John WIKSTRAND;
John WIKSTRAND
1The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, S-413 45 Gothenburg, Sweden
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Lillemor MATTSSON-HULTÉN;
Lillemor MATTSSON-HULTÉN
1The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, S-413 45 Gothenburg, Sweden
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Björn FAGERBERG
Björn FAGERBERG
1The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, S-413 45 Gothenburg, Sweden
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Publisher: Portland Press Ltd
Received:
December 19 2001
Revision Received:
February 11 2002
Accepted:
April 18 2002
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2002
2002
Clin Sci (Lond) (2002) 103 (2): 123–129.
Article history
Received:
December 19 2001
Revision Received:
February 11 2002
Accepted:
April 18 2002
Citation
Johannes HULTHE, John WIKSTRAND, Lillemor MATTSSON-HULTÉN, Björn FAGERBERG; Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (AIR) study. Clin Sci (Lond) 1 August 2002; 103 (2): 123–129. doi: https://doi.org/10.1042/cs1030123
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