Adiponectin, which is secreted specifically by adipose tissue, has been shown to act as an anti-atherosclerotic protein by direct effects on endothelial cells. Clinical studies have shown that adiponectin levels are lower in individuals with obesity, diabetes and coronary artery disease. The present study investigated relationships between serum adiponectin levels and body mass index (BMI), blood pressure, insulin resistance index, lipid profile, uric acid and high-sensitivity C-reactive protein levels in a large number of Japanese subjects not taking any medication for metabolic disease and without severe illness (705 men and 262 women; age 30–65 years; BMI 22.5±2.9kg/m2). The serum adiponectin concentration was measured by ELISA, without a protein-denaturing step. The insulin resistance index was assessed by homoeostasis model assessment (HOMA-IR). The serum concentration of adiponectin in women (13.5±7.9μg/ml) was significantly higher than that in men (7.2±4.6μg/ml). The serum adiponectin level was negatively correlated with BMI, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, insulin, HOMA-IR, total cholesterol, triacylglycerols, low-density lipoprotein (LDL)-cholesterol and uric acid, and positively correlated with high-density lipoprotein (HDL)-cholesterol. The correlations between serum adiponectin level and insulin, HOMA-IR, triacylglycerols, HDL-cholesterol, LDL-cholesterol and uric acid were significant even after adjustment for age, sex and BMI. Stepwise multiple regression analysis revealed that HDL-cholesterol, sex, BMI and HOMA-IR were independently correlated with the serum adiponectin level (R2 = 0.377). These findings suggest that the serum adiponectin level is negatively correlated with HOMA-IR and positively correlated with HDL-cholesterol, independent of age, sex and BMI, in the Japanese population.
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July 03 2002
Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population
Yukihiro YAMAMOTO;
*Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Correspondence: Dr Yukihiro Yamamoto (e-mail [email protected])
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Hiroshi HIROSE;
Hiroshi HIROSE
*Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
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Ikuo SAITO;
Ikuo SAITO
*Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
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Motowo TOMITA;
Motowo TOMITA
†Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
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Matsuo TANIYAMA;
Matsuo TANIYAMA
‡Department of Internal Medicine, Showa University Fujigaoka Hospital, Tokyo, Japan
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Koichi MATSUBARA;
Koichi MATSUBARA
§Chugai Diagnostics Science Co., Ltd., Tokyo, Japan
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Yasunori OKAZAKI;
Yasunori OKAZAKI
§Chugai Diagnostics Science Co., Ltd., Tokyo, Japan
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Tatsuya ISHII;
Tatsuya ISHII
*Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
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Kanako NISHIKAI;
Kanako NISHIKAI
*Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
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Takao SARUTA
Takao SARUTA
*Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
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Publisher: Portland Press Ltd
Received:
November 20 2001
Revision Received:
February 18 2002
Accepted:
April 19 2002
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2002
2002
Clin Sci (Lond) (2002) 103 (2): 137–142.
Article history
Received:
November 20 2001
Revision Received:
February 18 2002
Accepted:
April 19 2002
Citation
Yukihiro YAMAMOTO, Hiroshi HIROSE, Ikuo SAITO, Motowo TOMITA, Matsuo TANIYAMA, Koichi MATSUBARA, Yasunori OKAZAKI, Tatsuya ISHII, Kanako NISHIKAI, Takao SARUTA; Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond) 1 August 2002; 103 (2): 137–142. doi: https://doi.org/10.1042/cs1030137
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