Non-invasive continuous monitoring of cardiac output could be very useful in clinical care and in research settings, particularly in elderly subjects. We studied whether Finapres arterial pulse wave analysis with Modelflow® is a reliable non-invasive method for the assessment of cardiac output in healthy elderly subjects. We compared Modelflow® cardiac output (MFCO) with thermodilution cardiac output (TDCO) in 28 healthy subjects, aged 70±4years (mean±S.D.). TDCO was measured during right-sided heart catheterization, while MFCO was calculated with Modelflow® software from non-invasive arterial Finapres blood pressure, which was measured simultaneously. The two methods were compared using a paired t-test, by Pearson correlation, and by Bland–Altman analysis. TDCO was 6.4±1.1litres/min (mean±S.D.) and MFCO was 4.7±1.3litres/min (P<0.001). There was no significant correlation between MFCO and TDCO (r = 0.28, P = 0.13). Mean difference (bias) was -1.7litres/min (S.E.M. 0.27litres/min), with an S.D. (precision) of 1.5litres/min. The 95% limits of agreement were -4.6 to +1.1litres/min. In conclusion, non-invasive MFCO values differed significantly from and showed no significant correlation with invasively determined TDCO values in the normal range. Although simple, non-invasive and patient-friendly, the Modelflow® method is inaccurate for assessment of cardiac output without invasive calibration.
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Research Article|
June 28 2002
Finapres arterial pulse wave analysis with Modelflow® is not a reliable non-invasive method for assessment of cardiac output
Jaap J. REMMEN;
1Department of Geriatric Medicine, Heartcenter, Department of Cardiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
Correspondence: Dr Jaap J. Remmen (e-mail [email protected]).
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Wim R.M. AENGEVAEREN;
Wim R.M. AENGEVAEREN
1Department of Geriatric Medicine, Heartcenter, Department of Cardiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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Freek W.A. VERHEUGT;
Freek W.A. VERHEUGT
1Department of Geriatric Medicine, Heartcenter, Department of Cardiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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Tjeerd VAN DER WERF;
Tjeerd VAN DER WERF
1Department of Geriatric Medicine, Heartcenter, Department of Cardiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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Hans E. LUIJTEN;
Hans E. LUIJTEN
1Department of Geriatric Medicine, Heartcenter, Department of Cardiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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Anja BOS;
Anja BOS
1Department of Geriatric Medicine, Heartcenter, Department of Cardiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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René W.M.M. JANSEN
René W.M.M. JANSEN
1Department of Geriatric Medicine, Heartcenter, Department of Cardiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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Publisher: Portland Press Ltd
Received:
December 07 2001
Revision Received:
January 22 2002
Accepted:
April 18 2002
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2002
2002
Clin Sci (Lond) (2002) 103 (2): 143–149.
Article history
Received:
December 07 2001
Revision Received:
January 22 2002
Accepted:
April 18 2002
Citation
Jaap J. REMMEN, Wim R.M. AENGEVAEREN, Freek W.A. VERHEUGT, Tjeerd VAN DER WERF, Hans E. LUIJTEN, Anja BOS, René W.M.M. JANSEN; Finapres arterial pulse wave analysis with Modelflow® is not a reliable non-invasive method for assessment of cardiac output. Clin Sci (Lond) 1 August 2002; 103 (2): 143–149. doi: https://doi.org/10.1042/cs1030143
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